Lineage for d1ia4b_ (1ia4 B:)

  1. Root: SCOPe 2.07
  2. 2413226Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2477518Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. 2477519Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families) (S)
  5. 2477520Family c.71.1.1: Dihydrofolate reductases [53598] (4 protein domains)
  6. 2477723Protein Dihydrofolate reductases, eukaryotic type [53605] (7 species)
  7. 2477864Species Yeast (Candida albicans) [TaxId:5476] [53609] (17 PDB entries)
  8. 2477888Domain d1ia4b_: 1ia4 B: [62110]
    complexed with mes, ndp, tq6

Details for d1ia4b_

PDB Entry: 1ia4 (more details), 1.85 Å

PDB Description: candida albicans dihydrofolate reductase complex in which the dihydronicotinamide moiety of dihydro-nicotinamide-adenine- dinucleotide phosphate (nadph) is displaced by 5-{[4-(4-morpholinyl) phenyl]sulfanyl}-2,4-quinazolinediamin (gw2021)
PDB Compounds: (B:) dihydrofolate reductase

SCOPe Domain Sequences for d1ia4b_:

Sequence; same for both SEQRES and ATOM records: (download)

>d1ia4b_ c.71.1.1 (B:) Dihydrofolate reductases, eukaryotic type {Yeast (Candida albicans) [TaxId: 5476]}

SCOPe Domain Coordinates for d1ia4b_:

Click to download the PDB-style file with coordinates for d1ia4b_.
(The format of our PDB-style files is described here.)

Timeline for d1ia4b_: