SCOPe 2.07: Domain d1ia4a_: 1ia4 A:

Lineage for d1ia4a_ (1ia4 A:)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

4. Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families)

5. Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins)

6. Protein Dihydrofolate reductases, eukaryotic type [53605] (7 species)

7. Species Yeast (Candida albicans) [TaxId:5476] [53609] (17 PDB entries)

8. Domain d1ia4a_: 1ia4 A: [62109]
   complexed with mes, ndp, tq6

Details for d1ia4a_

PDB Entry: 1ia4, 1.85 Å

PDB Description: candida albicans dihydrofolate reductase complex in which the dihydronicotinamide moiety of dihydro-nicotinamide-adenine- dinucleotide phosphate (nadph) is displaced by 5-{[4-(4-morpholinyl) phenyl]sulfanyl}-2,4-quinazolinediamin (gw2021)

PDB Compounds: (A:) dihydrofolate reductase

SCOPe Domain Sequences for d1ia4a_:

Sequence; same for both SEQRES and ATOM records:

>d1ia4a_ c.71.1.1 (A:) Dihydrofolate reductases, eukaryotic type {Yeast (Candida albicans) [TaxId: 5476]}
mlkpnvaiivaalkpalgigykgkmpwrlrkeiryfkdvttrttkpntrnavimgrktwe
sipqkfrplpdrlniilsrsyeneiiddniihassiesslnlvsdvervfiiggaeiyne
linnslvshlliteiehpspesiemdtflkfpleswtkqpkselqkfvgdtvleddikeg
dftynytlwtrk

Timeline for d1ia4a_:

• d1ia4a_ first appeared in SCOP 1.57
  
• d1ia4a_ appears in SCOPe 2.06
  
• d1ia4a_ appears in the current release, SCOPe 2.08