SCOPe 2.05: Domain d1i4oa_: 1i4o A:

Lineage for d1i4oa_ (1i4o A:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.17: Caspase-like [52128] (1 superfamily)
   3 layers, a/b/a; core: mixed beta-sheet of 6 strands, order 213456, strand 6 is antiparallel to the rest

4. Superfamily c.17.1: Caspase-like [52129] (3 families)
   mature protein may be composed of two chains folded in a single domain

5. Family c.17.1.1: Caspase catalytic domain [52130] (8 proteins)

6. Protein Caspase-7 [63961] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [63962] (12 PDB entries)
   Uniprot P55210 57-303

8. Domain d1i4oa_: 1i4o A: [61721]
   Complexed to the xiap linker (chains C and D)

Details for d1i4oa_

PDB Entry: 1i4o, 2.4 Å

PDB Description: crystal structure of the xiap/caspase-7 complex

PDB Compounds: (A:) caspase-7

SCOPe Domain Sequences for d1i4oa_:

Sequence, based on SEQRES records:

>d1i4oa_ c.17.1.1 (A:) Caspase-7 {Human (Homo sapiens) [TaxId: 9606]}
vptyqynmnfeklgkciiinnknfdkvtgmgvrngtdkdaealfkcfrslgfdvivyndc
scakmqdllkkaseedhtnaacfacillshgeenviygkdgvtpikdltahfrgdrcktl
lekpklffiqacrgtelddgiqadsgpindtdanprykipveadflfaystvpgyyswrs
pgrgswfvqalcsileehgkdleimqiltrvndrvarhfesqsddphfhekkqipcvvsm
ltkelyfsq

Sequence, based on observed residues (ATOM records):

>d1i4oa_ c.17.1.1 (A:) Caspase-7 {Human (Homo sapiens) [TaxId: 9606]}
vptyqynmnfeklgkciiinnknfdkvtgmgvrngtdkdaealfkcfrslgfdvivyndc
scakmqdllkkaseedhtnaacfacillshgeenviygkdgvtpikdltahfrgdrcktl
lekpklffiqacrgtelddgiqykipveadflfaystvpgyyswrspgrgswfvqalcsi
leehgkdleimqiltrvndrvarhfesqsddphfhekkqipcvvsmltkelyfsq

Timeline for d1i4oa_:

• d1i4oa_ first appeared in SCOP 1.57
  
• d1i4oa_ appears in SCOPe 2.04
  
• d1i4oa_ appears in SCOPe 2.06
  
• d1i4oa_ appears in the current release, SCOPe 2.08