SCOPe 2.05: Domain d1i00b_: 1i00 B:

Lineage for d1i00b_ (1i00 B:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
   contains large mixed beta-sheet

4. Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families)
   automatically mapped to Pfam PF00303

5. Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)

6. Protein Thymidylate synthase [55833] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [55840] (24 PDB entries)

8. Domain d1i00b_: 1i00 B: [61476]
   complexed with d16, ump

Details for d1i00b_

PDB Entry: 1i00, 2.5 Å

PDB Description: crystal structure of human thymidylate synthase, ternary complex with dump and tomudex

PDB Compounds: (B:) Thymidylate synthase

SCOPe Domain Sequences for d1i00b_:

Sequence; same for both SEQRES and ATOM records:

>d1i00b_ d.117.1.1 (B:) Thymidylate synthase {Human (Homo sapiens) [TaxId: 9606]}
selqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvleel
lwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgaeyrd
mesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvvnsel
scqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhieplkiq
lqreprpfpklrilrkvekiddfkaedfqiegynphpt

Timeline for d1i00b_:

• d1i00b_ first appeared in SCOP 1.57
  
• d1i00b_ appears in SCOPe 2.04
  
• d1i00b_ appears in SCOPe 2.06
  
• d1i00b_ appears in the current release, SCOPe 2.08