SCOP 1.71: Domain d1hwkd2: 1hwk D:463-586,D:704-860

Lineage for d1hwkd2 (1hwk D:463-586,D:704-860)

1. Root: SCOP 1.71

2. Class d: Alpha and beta proteins (a+b) [53931] (286 folds)

3. Fold d.179: Substrate-binding domain of HMG-CoA reductase [56541] (1 superfamily)
   unusual fold

4. Superfamily d.179.1: Substrate-binding domain of HMG-CoA reductase [56542] (1 family)

5. Family d.179.1.1: Substrate-binding domain of HMG-CoA reductase [56543] (1 protein)

6. Protein Substrate-binding domain of HMG-CoA reductase [56544] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56545] (9 PDB entries)

8. Domain d1hwkd2: 1hwk D:463-586,D:704-860 [61337]
   Other proteins in same PDB: d1hwka1, d1hwkb1, d1hwkc1, d1hwkd1
   complexed with 117, adp; mutant

Details for d1hwkd2

PDB Entry: 1hwk, 2.22 Å

PDB Description: complex of the catalytic portion of human hmg-coa reductase with atorvastatin

SCOP Domain Sequences for d1hwkd2:

Sequence, based on SEQRES records:

>d1hwkd2 d.179.1.1 (D:463-586,D:704-860) Substrate-binding domain of HMG-CoA reductase {Human (Homo sapiens)}
sdaeiiqlvnakhipaykletliethergvsirrqllskklsepsslqylpyrdynyslv
mgaccenvigympipvgvagplcldekefqvpmattegclvastnrgcraiglgggassr
vladXksvvceavipakvvrevlkttteamievninknlvgsamagsiggynahaanivt
aiyiacgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnllpqqacl
qmlgvqgackdnpgenarqlarivcgtvmagelslmaalaag

Sequence, based on observed residues (ATOM records):

>d1hwkd2 d.179.1.1 (D:463-586,D:704-860) Substrate-binding domain of HMG-CoA reductase {Human (Homo sapiens)}
sdaeiiqletliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigy
mpipvgvagplcldekefqvpmattegclvastnrgcraiglgggassrvladXksvvce
avipakvvrevlkttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaa
qnvgssncitlmeasgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackd
npgenarqlarivcgtvmagelslmaalaag

Timeline for d1hwkd2:

• d1hwkd2 first appeared in SCOP 1.57
  
• d1hwkd2 appears in SCOP 1.69
  
• d1hwkd2 appears in SCOP 1.73
  
• d1hwkd2 appears in the current release, SCOPe 2.08