SCOP 1.63: Domain d1hwkd1: 1hwk D:587-703

Lineage for d1hwkd1 (1hwk D:587-703)

1. Root: SCOP 1.63

2. Class d: Alpha and beta proteins (a+b) [53931] (224 folds)

3. Fold d.58: Ferredoxin-like [54861] (44 superfamilies)
   alpha+beta sandwich with antiparallel beta-sheet; (beta-alpha-beta)x2

4. Superfamily d.58.20: NAD-binding domain of HMG-CoA reductase [55035] (1 family)

5. Family d.58.20.1: NAD-binding domain of HMG-CoA reductase [55036] (1 protein)

6. Protein NAD-binding domain of HMG-CoA reductase [55037] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [55038] (9 PDB entries)

8. Domain d1hwkd1: 1hwk D:587-703 [61336]
   Other proteins in same PDB: d1hwka2, d1hwkb2, d1hwkc2, d1hwkd2
   complexed with 117, adp; mutant

Details for d1hwkd1

PDB Entry: 1hwk, 2.22 Å

PDB Description: complex of the catalytic portion of human hmg-coa reductase with atorvastatin

SCOP Domain Sequences for d1hwkd1:

Sequence; same for both SEQRES and ATOM records:

>d1hwkd1 d.58.20.1 (D:587-703) NAD-binding domain of HMG-CoA reductase {Human (Homo sapiens)}
gmtrgpvvrlpracdsaevkawletsegfavikeafdstsrfarlqklhtsiagrnlyir
fqsrsgdamgmnmiskgtekalsklheyfpemqilavsgnyctdkkpaainwiegrg

Timeline for d1hwkd1:

• d1hwkd1 first appeared in SCOP 1.57
  
• d1hwkd1 appears in SCOP 1.61
  
• d1hwkd1 appears in SCOP 1.65
  
• d1hwkd1 appears in the current release, SCOPe 2.08