SCOPe 2.08: Domain d1hwkc2: 1hwk C:462-586,C:704-860

Lineage for d1hwkc2 (1hwk C:462-586,C:704-860)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.179: Substrate-binding domain of HMG-CoA reductase [56541] (1 superfamily)
   unusual fold

4. Superfamily d.179.1: Substrate-binding domain of HMG-CoA reductase [56542] (1 family)

5. Family d.179.1.1: Substrate-binding domain of HMG-CoA reductase [56543] (1 protein)

6. Protein Substrate-binding domain of HMG-CoA reductase [56544] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56545] (9 PDB entries)

8. Domain d1hwkc2: 1hwk C:462-586,C:704-860 [61335]
   Other proteins in same PDB: d1hwka1, d1hwkb1, d1hwkc1, d1hwkd1
   complexed with 117, adp

Details for d1hwkc2

PDB Entry: 1hwk, 2.22 Å

PDB Description: complex of the catalytic portion of human hmg-coa reductase with atorvastatin

PDB Compounds: (C:) hmg-coa reductase

SCOPe Domain Sequences for d1hwkc2:

Sequence; same for both SEQRES and ATOM records:

>d1hwkc2 d.179.1.1 (C:462-586,C:704-860) Substrate-binding domain of HMG-CoA reductase {Human (Homo sapiens) [TaxId: 9606]}
lsdaeiiqlvnakhipaykletliethergvsirrqllskklsepsslqylpyrdynysl
vmgaccenvigympipvgvagplcldekefqvpmattegclvastnrgcraiglgggass
rvladXksvvceavipakvvrevlkttteamievninknlvgsamagsiggynahaaniv
taiyiacgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnllpqqac
lqmlgvqgackdnpgenarqlarivcgtvmagelslmaalaag

Timeline for d1hwkc2:

• d1hwkc2 first appeared in SCOP 1.57
  
• d1hwkc2 appears in SCOPe 2.07