SCOPe 2.05: Domain d1hwkb2: 1hwk B:463-586,B:704-860

Lineage for d1hwkb2 (1hwk B:463-586,B:704-860)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.179: Substrate-binding domain of HMG-CoA reductase [56541] (1 superfamily)
   unusual fold

4. Superfamily d.179.1: Substrate-binding domain of HMG-CoA reductase [56542] (1 family)

5. Family d.179.1.1: Substrate-binding domain of HMG-CoA reductase [56543] (1 protein)

6. Protein Substrate-binding domain of HMG-CoA reductase [56544] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56545] (9 PDB entries)

8. Domain d1hwkb2: 1hwk B:463-586,B:704-860 [61333]
   Other proteins in same PDB: d1hwka1, d1hwkb1, d1hwkc1, d1hwkd1
   complexed with 117, adp

Details for d1hwkb2

PDB Entry: 1hwk, 2.22 Å

PDB Description: complex of the catalytic portion of human hmg-coa reductase with atorvastatin

PDB Compounds: (B:) hmg-coa reductase

SCOPe Domain Sequences for d1hwkb2:

Sequence, based on SEQRES records:

>d1hwkb2 d.179.1.1 (B:463-586,B:704-860) Substrate-binding domain of HMG-CoA reductase {Human (Homo sapiens) [TaxId: 9606]}
sdaeiiqlvnakhipaykletliethergvsirrqllskklsepsslqylpyrdynyslv
mgaccenvigympipvgvagplcldekefqvpmattegclvastnrgcraiglgggassr
vladXksvvceavipakvvrevlkttteamievninknlvgsamagsiggynahaanivt
aiyiacgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnllpqqacl
qmlgvqgackdnpgenarqlarivcgtvmagelslmaalaag

Sequence, based on observed residues (ATOM records):

>d1hwkb2 d.179.1.1 (B:463-586,B:704-860) Substrate-binding domain of HMG-CoA reductase {Human (Homo sapiens) [TaxId: 9606]}
sdaeiiqlvnaykletliethergvsirrqllskklsepsslqylpyrdynyslvmgacc
envigympipvgvagplcldekefqvpmattegclvastnrgcraiglgggassrvladX
ksvvceavipakvvrevlkttteamievninknlvgsamagsiggynahaanivtaiyia
cgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnllpqqaclqmlgv
qgackdnpgenarqlarivcgtvmagelslmaalaag

Timeline for d1hwkb2:

• d1hwkb2 first appeared in SCOP 1.57
  
• d1hwkb2 appears in SCOPe 2.04
  
• d1hwkb2 appears in SCOPe 2.06
  
• d1hwkb2 appears in the current release, SCOPe 2.08