Lineage for d1hwkb2 (1hwk B:463-586,B:704-860)

  1. Root: SCOPe 2.08
  2. 2923792Class d: Alpha and beta proteins (a+b) [53931] (396 folds)
  3. 3004881Fold d.179: Substrate-binding domain of HMG-CoA reductase [56541] (1 superfamily)
    unusual fold
  4. 3004882Superfamily d.179.1: Substrate-binding domain of HMG-CoA reductase [56542] (1 family) (S)
  5. 3004883Family d.179.1.1: Substrate-binding domain of HMG-CoA reductase [56543] (1 protein)
  6. 3004884Protein Substrate-binding domain of HMG-CoA reductase [56544] (2 species)
  7. 3004885Species Human (Homo sapiens) [TaxId:9606] [56545] (9 PDB entries)
  8. 3004891Domain d1hwkb2: 1hwk B:463-586,B:704-860 [61333]
    Other proteins in same PDB: d1hwka1, d1hwkb1, d1hwkc1, d1hwkd1
    complexed with 117, adp

Details for d1hwkb2

PDB Entry: 1hwk (more details), 2.22 Å

PDB Description: complex of the catalytic portion of human hmg-coa reductase with atorvastatin
PDB Compounds: (B:) hmg-coa reductase

SCOPe Domain Sequences for d1hwkb2:

Sequence, based on SEQRES records: (download)

>d1hwkb2 d.179.1.1 (B:463-586,B:704-860) Substrate-binding domain of HMG-CoA reductase {Human (Homo sapiens) [TaxId: 9606]}
sdaeiiqlvnakhipaykletliethergvsirrqllskklsepsslqylpyrdynyslv
mgaccenvigympipvgvagplcldekefqvpmattegclvastnrgcraiglgggassr
vladXksvvceavipakvvrevlkttteamievninknlvgsamagsiggynahaanivt
aiyiacgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnllpqqacl
qmlgvqgackdnpgenarqlarivcgtvmagelslmaalaag

Sequence, based on observed residues (ATOM records): (download)

>d1hwkb2 d.179.1.1 (B:463-586,B:704-860) Substrate-binding domain of HMG-CoA reductase {Human (Homo sapiens) [TaxId: 9606]}
sdaeiiqlvnaykletliethergvsirrqllskklsepsslqylpyrdynyslvmgacc
envigympipvgvagplcldekefqvpmattegclvastnrgcraiglgggassrvladX
ksvvceavipakvvrevlkttteamievninknlvgsamagsiggynahaanivtaiyia
cgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnllpqqaclqmlgv
qgackdnpgenarqlarivcgtvmagelslmaalaag

SCOPe Domain Coordinates for d1hwkb2:

Click to download the PDB-style file with coordinates for d1hwkb2.
(The format of our PDB-style files is described here.)

Timeline for d1hwkb2: