SCOP 1.57: Domain d1hwia2: 1hwi A:462-586,A:704-862

Lineage for d1hwia2 (1hwi A:462-586,A:704-862)

1. Root: SCOP 1.57

2. Class d: Alpha and beta proteins (a+b) [53931] (194 folds)

3. Fold d.179: Substrate-binding domain of HMG-CoA reductase [56541] (1 superfamily)

4. Superfamily d.179.1: Substrate-binding domain of HMG-CoA reductase [56542] (1 family)

5. Family d.179.1.1: Substrate-binding domain of HMG-CoA reductase [56543] (1 protein)

6. Protein Substrate-binding domain of HMG-CoA reductase [56544] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56545] (9 PDB entries)

8. Domain d1hwia2: 1hwi A:462-586,A:704-862 [61315]
   Other proteins in same PDB: d1hwia1, d1hwib1, d1hwic1, d1hwid1

Details for d1hwia2

PDB Entry: 1hwi, 2.3 Å

PDB Description: complex of the catalytic portion of human hmg-coa reductase with fluvastatin

SCOP Domain Sequences for d1hwia2:

Sequence, based on SEQRES records:

>d1hwia2 d.179.1.1 (A:462-586,A:704-862) Substrate-binding domain of HMG-CoA reductase {Human (Homo sapiens)}
lsdaeiiqlvnakhipaykletliethergvsirrqllskklsepsslqylpyrdynysl
vmgaccenvigympipvgvagplcldekefqvpmattegclvastnrgcraiglgggass
rvladXksvvceavipakvvrevlkttteamievninknlvgsamagsiggynahaaniv
taiyiacgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnllpqqac
lqmlgvqgackdnpgenarqlarivcgtvmagelslmaalaaghl

Sequence, based on observed residues (ATOM records):

>d1hwia2 d.179.1.1 (A:462-586,A:704-862) Substrate-binding domain of HMG-CoA reductase {Human (Homo sapiens)}
lsdaeiiqlvnletliethergvsirrqllskklsepsslqylpyrdynyslvmgaccen
vigympipvgvagplcldekefqvpmattegclvastnrgcraiglgggassrvladXks
vvceavipakvvrevlkttteamievninknlvgsamagsiggynahaanivtaiyiacg
qdaaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqg
ackdnpgenarqlarivcgtvmagelslmaalaaghl

Timeline for d1hwia2:

• d1hwia2 is new in SCOP 1.57
  
• d1hwia2 appears in SCOP 1.59
  
• d1hwia2 appears in the current release, SCOPe 2.08