Lineage for d1hw9c2 (1hw9 C:463-586,C:704-860)

  1. Root: SCOPe 2.07
  2. 2530962Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2610788Fold d.179: Substrate-binding domain of HMG-CoA reductase [56541] (1 superfamily)
    unusual fold
  4. 2610789Superfamily d.179.1: Substrate-binding domain of HMG-CoA reductase [56542] (1 family) (S)
  5. 2610790Family d.179.1.1: Substrate-binding domain of HMG-CoA reductase [56543] (1 protein)
  6. 2610791Protein Substrate-binding domain of HMG-CoA reductase [56544] (2 species)
  7. 2610792Species Human (Homo sapiens) [TaxId:9606] [56545] (9 PDB entries)
  8. 2610815Domain d1hw9c2: 1hw9 C:463-586,C:704-860 [61311]
    Other proteins in same PDB: d1hw9a1, d1hw9b1, d1hw9c1, d1hw9d1
    complexed with adp, sim

Details for d1hw9c2

PDB Entry: 1hw9 (more details), 2.33 Å

PDB Description: complex of the catalytic portion of human hmg-coa reductase with simvastatin
PDB Compounds: (C:) hmg-coa reductase

SCOPe Domain Sequences for d1hw9c2:

Sequence, based on SEQRES records: (download)

>d1hw9c2 d.179.1.1 (C:463-586,C:704-860) Substrate-binding domain of HMG-CoA reductase {Human (Homo sapiens) [TaxId: 9606]}
sdaeiiqlvnakhipaykletliethergvsirrqllskklsepsslqylpyrdynyslv
mgaccenvigympipvgvagplcldekefqvpmattegclvastnrgcraiglgggassr
vladXksvvceavipakvvrevlkttteamievninknlvgsamagsiggynahaanivt
aiyiacgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnllpqqacl
qmlgvqgackdnpgenarqlarivcgtvmagelslmaalaag

Sequence, based on observed residues (ATOM records): (download)

>d1hw9c2 d.179.1.1 (C:463-586,C:704-860) Substrate-binding domain of HMG-CoA reductase {Human (Homo sapiens) [TaxId: 9606]}
sdaeiiaykletliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvi
gympipvgvagplcldekefqvpmattegclvastnrgcraiglgggassrvladXksvv
ceavipakvvrevlkttteamievninknlvgsamagsiggynahaanivtaiyiacgqd
aaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgac
kdnpgenarqlarivcgtvmagelslmaalaag

SCOPe Domain Coordinates for d1hw9c2:

Click to download the PDB-style file with coordinates for d1hw9c2.
(The format of our PDB-style files is described here.)

Timeline for d1hw9c2: