SCOPe 2.05: Domain d1hw8b2: 1hw8 B:443-586,B:704-860

Lineage for d1hw8b2 (1hw8 B:443-586,B:704-860)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.179: Substrate-binding domain of HMG-CoA reductase [56541] (1 superfamily)
   unusual fold

4. Superfamily d.179.1: Substrate-binding domain of HMG-CoA reductase [56542] (1 family)

5. Family d.179.1.1: Substrate-binding domain of HMG-CoA reductase [56543] (1 protein)

6. Protein Substrate-binding domain of HMG-CoA reductase [56544] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56545] (9 PDB entries)

8. Domain d1hw8b2: 1hw8 B:443-586,B:704-860 [61301]
   Other proteins in same PDB: d1hw8a1, d1hw8b1, d1hw8c1, d1hw8d1
   complexed with 114, adp

Details for d1hw8b2

PDB Entry: 1hw8, 2.1 Å

PDB Description: complex of the catalytic portion of human hmg-coa reductase with compactin (also known as mevastatin)

PDB Compounds: (B:) hmg-coa reductase

SCOPe Domain Sequences for d1hw8b2:

Sequence, based on SEQRES records:

>d1hw8b2 d.179.1.1 (B:443-586,B:704-860) Substrate-binding domain of HMG-CoA reductase {Human (Homo sapiens) [TaxId: 9606]}
rpneeclqilgnaekgakflsdaeiiqlvnakhipaykletliethergvsirrqllskk
lsepsslqylpyrdynyslvmgaccenvigympipvgvagplcldekefqvpmattegcl
vastnrgcraiglgggassrvladXksvvceavipakvvrevlkttteamievninknlv
gsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlmeasgptnedlyisctmp
sieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlarivcgtvmagelslmaala
ag

Sequence, based on observed residues (ATOM records):

>d1hw8b2 d.179.1.1 (B:443-586,B:704-860) Substrate-binding domain of HMG-CoA reductase {Human (Homo sapiens) [TaxId: 9606]}
rpneeclqikflsdaeiiqlvnakhipaykletliethergvsirrqllskklsepsslq
ylpyrdynyslvmgaccenvigympipvgvagplcldekefqvpmattegclvastnrgc
raiglgggassrvladXksvvceavipakvvrevlkttteamievninknlvgsamagsi
ggynahaanivtaiyiacgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvg
ggtnllpqqaclqmlgvqgackdnpgenarqlarivcgtvmagelslmaalaag

Timeline for d1hw8b2:

• d1hw8b2 first appeared in SCOP 1.57
  
• d1hw8b2 appears in SCOPe 2.04
  
• d1hw8b2 appears in SCOPe 2.06
  
• d1hw8b2 appears in the current release, SCOPe 2.08