SCOPe 2.05: Domain d1hezb1: 1hez B:1-121

Lineage for d1hezb1 (1hez B:1-121)

1. Root: SCOPe 2.05

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (31 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)

6. Protein Immunoglobulin heavy chain variable domain, VH [88543] (21 species)
   VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Human (Homo sapiens), cluster 3 [TaxId:9606] [88547] (33 PDB entries)
   Uniprot Q6N089 20-243 # 95% sequence identity; natural chimera: antibody heavy chain (Fab HYB3)

8. Domain d1hezb1: 1hez B:1-121 [60985]
   Other proteins in same PDB: d1heza1, d1heza2, d1hezb2, d1hezc1, d1hezc2, d1hezd2, d1heze_
   part of IgM RF 2A2
   complexed with imd

Details for d1hezb1

PDB Entry: 1hez, 2.7 Å

PDB Description: structure of p. magnus protein l bound to a human igm fab.

PDB Compounds: (B:) heavy chain of ig

SCOPe Domain Sequences for d1hezb1:

Sequence; same for both SEQRES and ATOM records:

>d1hezb1 b.1.1.1 (B:1-121) Immunoglobulin heavy chain variable domain, VH {Human (Homo sapiens), cluster 3 [TaxId: 9606]}
qvqlvesgggvvqpgrslrlscaasgftfsgygmhwvrqapgkglewvalisydesnkyy
adsvkgrftisrdnskntlylqmnslraedtavyycakvkfydptapndywgqgtlvtvs
s

Timeline for d1hezb1:

• d1hezb1 first appeared in SCOP 1.57
  
• d1hezb1 appears in SCOPe 2.04
  
• d1hezb1 appears in SCOPe 2.06
  
• d1hezb1 appears in the current release, SCOPe 2.08