SCOP 1.75: Domain d1he4a_: 1he4 A:

Lineage for d1he4a_ (1he4 A:)

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (70 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein Biliverdin IX beta reductase [63931] (1 species)
   Histidine in the active site instead of the Tyr-Lys dyad

7. Species Human (Homo sapiens) [TaxId:9606] [63932] (5 PDB entries)

8. Domain d1he4a_: 1he4 A: [60968]
   complexed with fmn, nap

Details for d1he4a_

PDB Entry: 1he4, 1.4 Å

PDB Description: human biliverdin ix beta reductase: nadp/fmn ternary complex

PDB Compounds: (A:) biliverdin ix beta reductase

SCOP Domain Sequences for d1he4a_:

Sequence; same for both SEQRES and ATOM records:

>d1he4a_ c.2.1.2 (A:) Biliverdin IX beta reductase {Human (Homo sapiens) [TaxId: 9606]}
mavkkiaifgatgqtglttlaqavqagyevtvlvrdssrlpsegprpahvvvgdvlqaad
vdktvagqdavivllgtrndlspttvmsegarnivaamkahgvdkvvactsafllwdptk
vpprlqavtddhirmhkvlresglkyvavmpphigdqpltgaytvtldgrgpsrviskhd
lghfmlrclttdeydghstypshqy

Timeline for d1he4a_:

• d1he4a_ first appeared in SCOP 1.57
  
• d1he4a_ appears in SCOP 1.73
  
• d1he4a_ appears in SCOPe 2.01
  
• d1he4a_ appears in the current release, SCOPe 2.08