SCOP 1.75: Domain d1fe2a1: 1fe2 A:74-584

Lineage for d1fe2a1 (1fe2 A:74-584)

1. Root: SCOP 1.75

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.93: Heme-dependent peroxidases [48112] (1 superfamily)
   multihelical; consists of two all-alpha domains

4. Superfamily a.93.1: Heme-dependent peroxidases [48113] (3 families)

5. Family a.93.1.2: Myeloperoxidase-like [48132] (2 proteins)

6. Protein Prostaglandin H2 synthase [48136] (2 species)
   contains EGF-like module

7. Species Sheep (Ovis aries) [TaxId:9940] [48137] (20 PDB entries)
   Uniprot P05979 32-584

8. Domain d1fe2a1: 1fe2 A:74-584 [59778]
   Other proteins in same PDB: d1fe2a2
   complexed with bma, bog, coh, lax, nag

Details for d1fe2a1

PDB Entry: 1fe2, 3 Å

PDB Description: crystal structure of dihomo-gamma-linoleic acid bound in the cyclooxygenase channel of prostaglandin endoperoxide h synthase-1.

PDB Compounds: (A:) prostaglandin endoperoxide h synthase-1

SCOP Domain Sequences for d1fe2a1:

Sequence; same for both SEQRES and ATOM records:

>d1fe2a1 a.93.1.2 (A:74-584) Prostaglandin H2 synthase {Sheep (Ovis aries) [TaxId: 9940]}
iwtwlrttlrpspsfihfllthgrwlwdfvnatfirdtlmrlvltvrsnlipspptynia
hdyiswesfsnvsyytrilpsvprdcptpmgtkgkkqlpdaeflsrrfllrrkfipdpqg
tnlmfaffaqhfthqffktsgkmgpgftkalghgvdlghiygdnlerqyqlrlfkdgklk
yqmlngevyppsveeapvlmhyprgippqsqmavgqevfgllpglmlyatiwlrehnrvc
dllkaehptwgdeqlfqtarliligetikivieeyvqqlsgyflqlkfdpellfgaqfqy
rnriamefnqlyhwhplmpdsfrvgpqdysyeqflfntsmlvdygvealvdafsrqpagr
igggrnidhhilhvavdvikesrvlrlqpfneyrkrfgmkpytsfqeltgekemaaelee
lygdidalefypglllekchpnsifgesmiemgapfslkgllgnpicspeywkastfgge
vgfnlvktatlkklvclntktcpyvsfhvpd

Timeline for d1fe2a1:

• d1fe2a1 first appeared in SCOP 1.57
  
• d1fe2a1 appears in SCOP 1.73
  
• d1fe2a1 appears in SCOPe 2.01
  
• d1fe2a1 appears in the current release, SCOPe 2.08