SCOP 1.59: Domain d1e7wa_: 1e7w A:

Lineage for d1e7wa_ (1e7w A:)

1. Root: SCOP 1.59

2. Class c: Alpha and beta proteins (a/b) [51349] (113 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (10 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (27 proteins)

6. Protein Dihydropteridin reductase (pteridine reductase) [51769] (3 species)

7. Species Leishmania major [TaxId:5664] [63926] (2 PDB entries)

8. Domain d1e7wa_: 1e7w A: [59373]

Details for d1e7wa_

PDB Entry: 1e7w, 1.75 Å

PDB Description: one active site, two modes of reduction correlate the mechanism of leishmania pteridine reductase with pterin metabolism and antifolate drug resistance in trpanosomes

SCOP Domain Sequences for d1e7wa_:

Sequence, based on SEQRES records:

>d1e7wa_ c.2.1.2 (A:) Dihydropteridin reductase (pteridine reductase) {Leishmania major}
tvpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsaitvqa
dlsnvatapvsgadgsapvtlftrcaelvaacythwgrcdvlvnnassfyptpllrnded
ghepcvgdreametatadlfgsnaiapyflikafahrvagtpakhrgtnysiinmvdamt
nqpllgytiytmakgalegltrsaalelaplqirvngvgpglsvlvddmppavweghrsk
vplyqrdssaaevsdvviflcsskakyitgtcvkvdggysltra

Sequence, based on observed residues (ATOM records):

>d1e7wa_ c.2.1.2 (A:) Dihydropteridin reductase (pteridine reductase) {Leishmania major}
tvpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsaitvqa
dlsnvatapvssapvtlftrcaelvaacythwgrcdvlvnnassfyptpllreametata
dlfgsnaiapyflikafahrvagtpakhrgtnysiinmvdamtnqpllgytiytmakgal
egltrsaalelaplqirvngvgpglsvlvddmppavweghrskvplyqrdssaaevsdvv
iflcsskakyitgtcvkvdggysltra

Timeline for d1e7wa_:

• d1e7wa_ first appeared in SCOP 1.57
  
• d1e7wa_ appears in SCOP 1.61
  
• d1e7wa_ appears in the current release, SCOPe 2.08