SCOPe 2.01: Domain d1e51b_: 1e51 B:

Lineage for d1e51b_ (1e51 B:)

1. Root: SCOPe 2.01

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.10: Aldolase [51569] (9 families)
   Common fold covers whole protein structure

5. Family c.1.10.3: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) [51594] (2 proteins)
   hybrid of classes I and II aldolase

6. Protein 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) [51595] (5 species)

7. Species Human (Homo sapiens) [TaxId:9606] [63921] (2 PDB entries)

8. Domain d1e51b_: 1e51 B: [59255]
   complexed with pbg, so4, zn

Details for d1e51b_

PDB Entry: 1e51, 2.83 Å

PDB Description: crystal structure of native human erythrocyte 5-aminolaevulinic acid dehydratase

PDB Compounds: (B:) delta-aminolevulinic acid dehydratase

SCOPe Domain Sequences for d1e51b_:

Sequence, based on SEQRES records:

>d1e51b_ c.1.10.3 (B:) 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) {Human (Homo sapiens) [TaxId: 9606]}
mqpqsvlhsgyfhpllrawqtatttlnasnliypifvtdvpddiqpitslpgvarygvkr
leemlrplveeglrcvlifgvpsrvpkdergsaadseespaieaihllrktfpnllvacd
vclcpytshghcgllsengafraeesrqrlaevalayakagcqvvapsdmmdgrveaike
almahglgnrvsvmsysakfascfygpfrdaaksspafgdrrcyqlppgarglalravdr
dvregadmlmvkpgmpyldivrevkdkhpdlplavyhvsgefamlwhgaqagafdlkaav
leamtafrragadiiityytpqllqwlk

Sequence, based on observed residues (ATOM records):

>d1e51b_ c.1.10.3 (B:) 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) {Human (Homo sapiens) [TaxId: 9606]}
mqpqsvlhsgyfhpllrawqtatttlnasnliypifvtdvpddiqpitslpgvarygvkr
leemlrplveeglrcvlifgvpsrvpkdadseespaieaihllrktfpnllvacdvclcp
yaeesrqrlaevalayakagcqvvapsdmmdgrveaikealmahglgnrvsvmsysakfa
scfygpfrdaarrcyqlppgarglalravdrdvregadmlmvkpgmpyldivrevkdkhp
dlplavyhvsgefamlwhgaqagafdlkaavleamtafrragadiiityytpqllqwlk

Timeline for d1e51b_:

• d1e51b_ first appeared in SCOP 1.57
  
• d1e51b_ appears in SCOP 1.75
  
• d1e51b_ appears in SCOPe 2.02
  
• d1e51b_ appears in the current release, SCOPe 2.08