Lineage for Fold h.4: Antiparallel coiled-coil

  1. Root: SCOP 1.75
  2. 894739Class h: Coiled coil proteins [57942] (7 folds)
  3. 896123Fold h.4: Antiparallel coiled-coil [58086] (17 superfamilies)
    this is not a true fold; contains at least two very long antiparallel helices

Superfamilies:

  1. 896124h.4.1: Variant surface glycoprotein (N-terminal domain) [58087] (1 family) (S)
  2. 896132h.4.2: Clostridium neurotoxins, "coiled-coil" domain [58091] (1 family) (S)
  3. 896152h.4.3: Colicin Ia, N-terminal domain [58096] (1 family) (S)
  4. 896157h.4.4: Bacterial hemolysins [58100] (2 families) (S)
  5. 896166h.4.5: Methyl-accepting chemotaxis protein (MCP) signaling domain [58104] (1 family) (S)
  6. 896176h.4.6: Oligomerization domain of hepatitis delta antigen [58108] (1 family) (S)
  7. 896185h.4.8: F1 ATPase inhibitor, IF1, C-terminal domain [64602] (1 family) (S)
  8. 896197h.4.9: Colicin E3 receptor domain [69985] (1 family) (S)
  9. 896207h.4.10: C-terminal domain of PLC-beta [69989] (1 family) (S)
    left-handed antiparallel coiled-coil; dimerizes with the formation of a 4-helical bundle
  10. 896213h.4.11: Chemotaxis phosphatase CheZ [75708] (1 family) (S)
    dimerizes with the formation of a 4-helical bundle
  11. 896218h.4.12: Rad50 coiled-coil Zn hook [75712] (1 family) (S)
    dimerizes via a CxxC motif in the loop, zinc-hook
  12. 896224h.4.13: Tumor suppressor gene product Apc [82931] (1 family) (S)
  13. 896229h.4.15: Proline/betaine transporter ProP, C-terminal cytoplasmic domain [103661] (1 family) (S)
  14. 896235h.4.16: Fzo-like conserved region [111479] (1 family) (S)
    antiparallel coiled-coil in the crystals
  15. 896240h.4.17: occludin/ELL-like [144292] (1 family) (S)
    antiparallel hairpin with a kinked second helix; similar to the N-terminal structure of the thermostable carboxypeptidase 1 ((82731))
  16. 896246h.4.18: Gam-like [161266] (1 family) (S)
    homodimeric fold with a ring-like structure formed by kinked coiled-coil and a beta-ribboon, interrupted by small helical insertions
  17. 896252h.4.19: PspA lactotransferrin-binding region [161270] (1 family) (S)
    3 helices, the middle one is longer than the two others

More info for Fold h.4: Antiparallel coiled-coil

Timeline for Fold h.4: Antiparallel coiled-coil: