SCOPe 2.08: Fold h.4: Antiparallel coiled-coil

Lineage for Fold h.4: Antiparallel coiled-coil

1. Root: SCOPe 2.08

2. Class h: Coiled coil proteins [57942] (7 folds)

3. Fold h.4: Antiparallel coiled-coil [58086] (19 superfamilies)
   this is not a true fold; contains at least two very long antiparallel helices

Superfamilies:

1. h.4.1: Variant surface glycoprotein (N-terminal domain) [58087] (2 families)

2. h.4.2: Clostridium neurotoxins, 'coiled-coil' domain [58091] (1 family)

3. h.4.3: Colicin Ia, N-terminal domain [58096] (1 family)

4. h.4.4: Bacterial hemolysins [58100] (2 families)

5. h.4.5: Methyl-accepting chemotaxis protein (MCP) signaling domain [58104] (1 family)

6. h.4.6: Oligomerization domain of hepatitis delta antigen [58108] (1 family)

7. h.4.8: F1 ATPase inhibitor, IF1, C-terminal domain [64602] (1 family)

8. h.4.9: Colicin E3 receptor domain [69985] (1 family)

9. h.4.10: C-terminal domain of PLC-beta [69989] (1 family)
   left-handed antiparallel coiled-coil; dimerizes with the formation of a 4-helical bundle

10. h.4.11: Chemotaxis phosphatase CheZ [75708] (1 family)
    dimerizes with the formation of a 4-helical bundle

11. h.4.12: Rad50 coiled-coil Zn hook [75712] (1 family)
    dimerizes via a CxxC motif in the loop, zinc-hook

12. h.4.13: Tumor suppressor gene product Apc [82931] (1 family)

13. h.4.15: Proline/betaine transporter ProP, C-terminal cytoplasmic domain [103661] (1 family)

14. h.4.16: Fzo-like conserved region [111479] (1 family)
    antiparallel coiled-coil in the crystals

15. h.4.17: occludin/ELL-like [144292] (2 families)
    antiparallel hairpin with a kinked second helix; similar to the N-terminal structure of the thermostable carboxypeptidase 1 (82731)

16. h.4.18: Gam-like [161266] (1 family)
    homodimeric fold with a ring-like structure formed by kinked coiled-coil and a beta-ribboon, interrupted by small helical insertions

17. h.4.19: PspA lactotransferrin-binding region [161270] (1 family)
    3 helices, the middle one is longer than the two others

18. h.4.20: V-type ATPase central rotor subunit D [310580] (2 families)
    Role similar to F1 ATP synthase gamma (c.49.2), but do not appear to be homologous
    Has 2 antiparallel beta strands in addition to coiled coils; see PubMed 25971514

19. h.4.21: Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 (iSH2) domain-like [310606] (1 family)
    Pfam PF16454

More info for Fold h.4: Antiparallel coiled-coil

Timeline for Fold h.4: Antiparallel coiled-coil:

• Fold h.4: Antiparallel coiled-coil first appeared (with stable ids) in SCOP 1.55
  
• Fold h.4: Antiparallel coiled-coil appears in SCOPe 2.07