SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Fold h.4: Antiparallel coiled-coil

  1. Root: SCOPe 2.06
  2. 2237529Class h: Coiled coil proteins [57942] (7 folds)
  3. 2239862Fold h.4: Antiparallel coiled-coil [58086] (19 superfamilies)
    this is not a true fold; contains at least two very long antiparallel helices

Superfamilies:

  1. 2239863h.4.1: Variant surface glycoprotein (N-terminal domain) [58087] (1 family) (S)
  2. 2239871h.4.2: Clostridium neurotoxins, "coiled-coil" domain [58091] (1 family) (S)
  3. 2239894h.4.3: Colicin Ia, N-terminal domain [58096] (1 family) (S)
  4. 2239899h.4.4: Bacterial hemolysins [58100] (2 families) (S)
  5. 2239917h.4.5: Methyl-accepting chemotaxis protein (MCP) signaling domain [58104] (1 family) (S)
  6. 2239927h.4.6: Oligomerization domain of hepatitis delta antigen [58108] (1 family) (S)
  7. 2239936h.4.8: F1 ATPase inhibitor, IF1, C-terminal domain [64602] (1 family) (S)
  8. 2239950h.4.9: Colicin E3 receptor domain [69985] (1 family) (S)
  9. 2239960h.4.10: C-terminal domain of PLC-beta [69989] (1 family) (S)
    left-handed antiparallel coiled-coil; dimerizes with the formation of a 4-helical bundle
  10. 2239966h.4.11: Chemotaxis phosphatase CheZ [75708] (1 family) (S)
    dimerizes with the formation of a 4-helical bundle
  11. 2239971h.4.12: Rad50 coiled-coil Zn hook [75712] (1 family) (S)
    dimerizes via a CxxC motif in the loop, zinc-hook
  12. 2239977h.4.13: Tumor suppressor gene product Apc [82931] (1 family) (S)
  13. 2239982h.4.15: Proline/betaine transporter ProP, C-terminal cytoplasmic domain [103661] (1 family) (S)
  14. 2239988h.4.16: Fzo-like conserved region [111479] (1 family) (S)
    antiparallel coiled-coil in the crystals
  15. 2239993h.4.17: occludin/ELL-like [144292] (2 families) (S)
    antiparallel hairpin with a kinked second helix; similar to the N-terminal structure of the thermostable carboxypeptidase 1 (82731)
  16. 2240000h.4.18: Gam-like [161266] (1 family) (S)
    homodimeric fold with a ring-like structure formed by kinked coiled-coil and a beta-ribboon, interrupted by small helical insertions
  17. 2240006h.4.19: PspA lactotransferrin-binding region [161270] (1 family) (S)
    3 helices, the middle one is longer than the two others
  18. 2240012h.4.20: V-type ATPase central rotor subunit D [310580] (2 families) (S)
    Role similar to F1 ATP synthase gamma (c.49.2), but do not appear to be homologous
    Has 2 antiparallel beta strands in addition to coiled coils; see PubMed 25971514
  19. 2240026h.4.21: Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 (iSH2) domain-like [310606] (1 family) (S)
    Pfam PF16454

More info for Fold h.4: Antiparallel coiled-coil

Timeline for Fold h.4: Antiparallel coiled-coil: