SCOPe 2.05: Family h.1.15.1: SNARE fusion complex

Lineage for Family h.1.15.1: SNARE fusion complex

1. Root: SCOPe 2.05

2. Class h: Coiled coil proteins [57942] (7 folds)

3. Fold h.1: Parallel coiled-coil [57943] (35 superfamilies)
   this is not a true fold; includes oligomers of shorter identical helices

4. Superfamily h.1.15: SNARE fusion complex [58038] (2 families)
   tetrameric parallel coiled coil

5. Family h.1.15.1: SNARE fusion complex [58039] (12 proteins)

Proteins:

1. Complexin [88921] (1 species)

   • Species Norway rat (Rattus norvegicus) [TaxId:10116] [88922] (1 PDB entry)

2. Endobrevin [88906] (1 species)

   • Species Norway rat (Rattus norvegicus) [TaxId:10116] [88907] (1 PDB entry)

3. M-tomosyn [111467] (1 species)

   • Species Norway rat (Rattus norvegicus) [TaxId:10116] [111468] (1 PDB entry)
     Uniprot Q9Z152

4. Synaphin [88923] (1 species)

   • Species Longfin inshore squid (Loligo pealei) [TaxId:6621] [88924] (1 PDB entry)

5. Synaptobrevin [88903] (3 species)

   1. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [161253] (1 PDB entry)

   2. Species Longfin inshore squid (Loligo pealei) [TaxId:6621] [88905] (1 PDB entry)

   3. Species Norway rat (Rattus norvegicus) [TaxId:10116] [88904] (4 PDB entries)

6. Synaptosomal-associated protein SNAP-23 [90240] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [90241] (1 PDB entry)

7. Synaptosomal-associated protein SNAP-25 [88915] (3 species)
   provides up to two different helical regions to synaptic fusion complexes

   1. Species Human (Homo sapiens) [TaxId:9606] [88917] (4 PDB entries)
      Uniprot P60880 146-204 # identical sequence to rat species

   2. Species Longfin inshore squid (Loligo pealei) [TaxId:6621] [88918] (1 PDB entry)

   3. Species Norway rat (Rattus norvegicus) [TaxId:10116] [88916] (4 PDB entries)
      Uniprot P13795 7-83; 142-204 # identical sequences to human species

8. Syntaxin 1A [88908] (3 species)

   1. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [161254] (1 PDB entry)

   2. Species Longfin inshore squid (Loligo pealei) [TaxId:6621] [88910] (1 PDB entry)

   3. Species Norway rat (Rattus norvegicus) [TaxId:10116] [88909] (6 PDB entries)
      Uniprot P32851 196-259
      a globular structure of a larger fragment containing this region is available; seepdb:1dn1, chain B

9. Syntaxin 7 [88911] (1 species)
   complex with endobrevin, VTI1B and syntaxin 8

   • Species Mouse (Mus musculus) [TaxId:10090] [88912] (1 PDB entry)

10. Syntaxin 8 [88913] (1 species)

    • Species Norway rat (Rattus norvegicus) [TaxId:10116] [88914] (1 PDB entry)

11. Vesicle transport v-SNARE protein VTI1b [88919] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [88920] (1 PDB entry)

12. automated matches [254664] (3 species)
    not a true protein

    1. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [255760] (1 PDB entry)

    2. Species Homo sapiens [TaxId:9606] [273431] (1 PDB entry)

    3. Species Norway rat (Rattus norvegicus) [TaxId:10116] [256060] (2 PDB entries)

More info for Family h.1.15.1: SNARE fusion complex

Timeline for Family h.1.15.1: SNARE fusion complex:

• Family h.1.15.1: SNARE fusion complex first appeared (with stable ids) in SCOP 1.55, called Family h.1.15.1: Neuronal synaptic fusion complex
  
• Family h.1.15.1: SNARE fusion complex appears in SCOPe 2.04
  
• Family h.1.15.1: SNARE fusion complex appears in SCOPe 2.06
  
• Family h.1.15.1: SNARE fusion complex appears in the current release, SCOPe 2.08