SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Fold h.1: Parallel coiled-coil

  1. Root: SCOPe 2.06
  2. 2237529Class h: Coiled coil proteins [57942] (7 folds)
  3. 2237530Fold h.1: Parallel coiled-coil [57943] (38 superfamilies)
    this is not a true fold; includes oligomers of shorter identical helices

Superfamilies:

  1. 2237531h.1.1: Triple coiled coil domain of C-type lectins [57944] (1 family) (S)
  2. 2237691h.1.2: Trimerization domain of TRAF [57953] (1 family) (S)
  3. 2237752h.1.3: Leucine zipper domain [57959] (1 family) (S)
  4. 2238068h.1.4: Inovirus (filamentous phage) major coat protein [57987] (1 family) (S)
  5. 2238110h.1.5: Tropomyosin [57997] (2 families) (S)
  6. 2238154h.1.6: Chicken cartilage matrix protein [58002] (1 family) (S)
  7. 2238161h.1.7: Assembly domain of cartilage oligomeric matrix protein [58006] (1 family) (S)
  8. 2238200h.1.8: Fibrinogen coiled-coil and central regions [58010] (2 families) (S)
  9. 2238370h.1.9: Coiled-coil domain of nucleotide exchange factor GrpE [58014] (1 family) (S)
  10. 2238376h.1.10: Coiled-coil dimerization domain from cortexillin I [58018] (1 family) (S)
  11. 2238383h.1.11: XRCC4, C-terminal oligomerization domain [58022] (1 family) (S)
  12. 2238395h.1.12: Delta-sleep-inducing peptide immunoreactive peptide [58026] (1 family) (S)
  13. 2238401h.1.13: Rotavirus nonstructural proteins [58030] (2 families) (S)
    not a true superfamily
  14. 2238442h.1.14: Multimerization domain of the phosphoprotein from sendai virus [58034] (1 family) (S)
  15. 2238447h.1.15: SNARE fusion complex [58038] (2 families) (S)
    tetrameric parallel coiled coil
  16. 2238552h.1.16: Outer membrane lipoprotein [58042] (1 family) (S)
  17. 2238576h.1.17: Fibritin [58046] (1 family) (S)
  18. 2238600h.1.18: N-terminal coiled coil domain from apc [58050] (1 family) (S)
  19. 2238606h.1.19: Tetrabrachion [58054] (1 family) (S)
  20. 2238620h.1.20: Intermediate filament protein, coiled coil region [64593] (2 families) (S)
  21. 2238647h.1.21: Eea1 homodimerisation domain [69979] (1 family) (S)
  22. 2238653h.1.22: Mitotic arrest deficient-like 1, Mad1 [75704] (1 family) (S)
  23. 2238661h.1.23: Dimerization motif of sir4 [90242] (1 family) (S)
  24. 2238668h.1.24: Head morphogenesis protein gp7 [90246] (1 family) (S)
  25. 2238688h.1.25: Troponin coil-coiled subunits [90250] (2 families) (S)
    form heterodimeric coiled coil
  26. 2238709h.1.26: Myosin rod fragments [90257] (2 families) (S)
  27. 2238727h.1.27: G protein-binding domain [103652] (2 families) (S)
  28. 2238752h.1.28: Geminin coiled-coil domain [111469] (2 families) (S)
  29. 2238777h.1.29: Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain [118370] (1 family) (S)
    tetrameric parallel coiled coil with a right-handed twist
  30. 2238783h.1.30: MPN010-like [144266] (1 family) (S)
    segmented trimeric coiled coil
  31. 2238790h.1.31: Eferin C-derminal domain-like [144270] (1 family) (S)
  32. 2238812h.1.32: Heterotrimerisation domain of extracellular hemoglobin linker subunits [144276] (1 family) (S)
  33. 2238823h.1.33: Sec2 N-terminal region [144284] (1 family) (S)
    dimeric coiled coil
  34. 2238856h.1.34: RILP dimerisation region [161256] (1 family) (S)
  35. 2238861h.1.35: Demethylase interaction domain of CoREST [267603] (1 family) (S)
    Includes N-terminal part of Pfam PF01448, ELM2 domain, which interacts with LSD1
  36. 2238886h.1.36: V-type ATPase peripheral stalk subunit E coiled coil [310578] (1 family) (S)
    Unusual right-handed coiled coil noted in PubMed 20173764
  37. 2238899h.1.37: V-type ATPase peripheral stalk subunit G coiled coil [310579] (1 family) (S)
    Unusual right-handed coiled coil noted in PubMed 20173764
  38. 2238914h.1.38: N-terminal linker of 6-deoxyerythronolide B synthase (DEBS) [310589] (1 family) (S)

More info for Fold h.1: Parallel coiled-coil

Timeline for Fold h.1: Parallel coiled-coil: