SCOPe 2.03: Family g.18.1.1: Complement control module/SCR domain

Lineage for Family g.18.1.1: Complement control module/SCR domain

1. Root: SCOPe 2.03

2. Class g: Small proteins [56992] (90 folds)

3. Fold g.18: Complement control module/SCR domain [57534] (1 superfamily)
   disulfide-rich all-beta fold

4. Superfamily g.18.1: Complement control module/SCR domain [57535] (1 family)

5. Family g.18.1.1: Complement control module/SCR domain [57536] (14 proteins)
   Pfam PF00084

Proteins:

1. beta2-glycoprotein I [57543] (1 species)
   consists of five modules with the C-terminal module fold being altered

   • Species Human (Homo sapiens) [TaxId:9606] [57544] (5 PDB entries)

2. CD46 (membrane cofactor protein, MCP) [57541] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [57542] (2 PDB entries)

3. Complement C1R protease domains [75682] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [75683] (3 PDB entries)

4. Complement C1S protease domain [64566] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [64567] (1 PDB entry)

5. Complement control protein [57539] (1 species)

   • Species Vaccinia virus [TaxId:10245] [57540] (8 PDB entries)
     Uniprot P10998
     a complement protein that regulates both pathways of complement activation and binds heparan sulfate proteoglycans

6. Complement decay-accelerating factor (Daf, CD55) [90172] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [90173] (18 PDB entries)

7. Complement factor B [144115] (1 species)
   contains tandemrepeat of three SCR (Sushi) domains

   • Species Human (Homo sapiens) [TaxId:9606] [144116] (1 PDB entry)
     Uniprot P00751 102-162! Uniprot P00751 163-224! Uniprot P00751 34-101

8. Complement receptor 1, cr1 [75680] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [75681] (3 PDB entries)

9. Complement receptor 2, cr2 [64564] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [64565] (4 PDB entries)

10. Factor H, 15th and 16th modules [57537] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [57538] (3 PDB entries)

11. GABA-B receptor 1 [118257] (1 species)

    • Species Norway rat (Rattus norvegicus) [TaxId:10116] [118258] (2 PDB entries)
      Uniprot Q9Z0U4 96-159

12. Interleukin-15 receptor subunit alpha [161139] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [161141] (4 PDB entries)
       Uniprot Q13261 31-108! Uniprot Q13261 31-96

    2. Species Mouse (Mus musculus) [TaxId:10090] [161140] (1 PDB entry)
       Uniprot Q60819 35-103

13. Interleukin-2 receptor alpha chain [144117] (1 species)
    consists of two segment-swapped SCR domains

    • Species Human (Homo sapiens) [TaxId:9606] [144118] (4 PDB entries)
      Uniprot P01589 121-186! Uniprot P01589 124-186! Uniprot P01589 125-186! Uniprot P01589 22-85

14. Mannan-binding lectin serine protease 2 (MASP-2) domains [111409] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [111410] (2 PDB entries)
      Uniprot O00187 366-686

More info for Family g.18.1.1: Complement control module/SCR domain

Timeline for Family g.18.1.1: Complement control module/SCR domain:

• Family g.18.1.1: Complement control module/SCR domain first appeared (with stable ids) in SCOP 1.55
  
• Family g.18.1.1: Complement control module/SCR domain appears in SCOPe 2.02
  
• Family g.18.1.1: Complement control module/SCR domain appears in SCOPe 2.04
  
• Family g.18.1.1: Complement control module/SCR domain appears in the current release, SCOPe 2.08