SCOP 1.73: Family g.18.1.1: Complement control module/SCR domain

Lineage for Family g.18.1.1: Complement control module/SCR domain

1. Root: SCOP 1.73

2. Class g: Small proteins [56992] (85 folds)

3. Fold g.18: Complement control module/SCR domain [57534] (1 superfamily)
   disulfide-rich all-beta fold

4. Superfamily g.18.1: Complement control module/SCR domain [57535] (1 family)

5. Family g.18.1.1: Complement control module/SCR domain [57536] (13 proteins)
   Pfam PF00084

Proteins:

1. beta2-glycoprotein I [57543] (1 species)
   consists of five modules with the C-terminal module fold being altered

   • Species Human (Homo sapiens) [TaxId:9606] [57544] (4 PDB entries)

2. CD46 (membrane cofactor protein, MCP) [57541] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [57542] (2 PDB entries)

3. Complement C1R protease domains [75682] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [75683] (4 PDB entries)

4. Complement C1S protease domain [64566] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [64567] (1 PDB entry)

5. Complement control protein [57539] (1 species)

   • Species Vaccinia virus [TaxId:10245] [57540] (8 PDB entries)
     a complement protein that regulates both pathways of complement activation and binds heparan sulfate proteoglycans

6. Complement decay-accelerating factor (Daf, CD55) [90172] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [90173] (15 PDB entries)

7. Complement factor B [144115] (1 species)
   contains tandemrepeat of three SCR (Sushi) domains

   • Species Human (Homo sapiens) [TaxId:9606] [144116] (1 PDB entry)

8. Complement receptor 1, cr1 [75680] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [75681] (3 PDB entries)

9. Complement receptor 2, cr2 [64564] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [64565] (4 PDB entries)

10. Factor H, 15th and 16th modules [57537] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [57538] (3 PDB entries)

11. GABA-B receptor 1 [118257] (1 species)

    • Species Rat (Rattus norvegicus) [TaxId:10116] [118258] (2 PDB entries)

12. Interleukin-2 receptor alpha chain [144117] (1 species)
    consists of two segment-swapped SCR domains

    • Species Human (Homo sapiens) [TaxId:9606] [144118] (3 PDB entries)

13. Mannan-binding lectin serine protease 2 (MASP-2) domains [111409] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [111410] (2 PDB entries)

More info for Family g.18.1.1: Complement control module/SCR domain

Timeline for Family g.18.1.1: Complement control module/SCR domain:

• Family g.18.1.1: Complement control module/SCR domain first appeared (with stable ids) in SCOP 1.55
  
• Family g.18.1.1: Complement control module/SCR domain appears in SCOP 1.71
  
• Family g.18.1.1: Complement control module/SCR domain appears in SCOP 1.75
  
• Family g.18.1.1: Complement control module/SCR domain appears in the current release, SCOPe 2.08