SCOPe 2.01: Family g.7.1.3: Extracellular domain of cell surface receptors

Lineage for Family g.7.1.3: Extracellular domain of cell surface receptors

1. Root: SCOPe 2.01

2. Class g: Small proteins [56992] (90 folds)

3. Fold g.7: Snake toxin-like [57301] (1 superfamily)
   disulfide-rich fold: nearly all-beta

4. Superfamily g.7.1: Snake toxin-like [57302] (4 families)

5. Family g.7.1.3: Extracellular domain of cell surface receptors [57354] (7 proteins)

Proteins:

1. BMP receptor Ia ectodomain [57359] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [57360] (5 PDB entries)

2. CD59 [57355] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [57356] (6 PDB entries)

3. TGF-beta type II receptor extracellular domain [69951] (2 species)
   elaborated with additional structures resulting in a beta-sandwich fold

   1. Species Chicken (Gallus gallus) [TaxId:9031] [82900] (1 PDB entry)

   2. Species Human (Homo sapiens) [TaxId:9606] [69952] (4 PDB entries)

4. Type II activin receptor [57357] (3 species)

   1. Species Mouse (Mus musculus) [TaxId:10090] [57358] (3 PDB entries)

   2. Species Mouse (Mus musculus), isoform IIB [TaxId:10090] [111406] (1 PDB entry)
      Uniprot P27040 23-120; 100% sequence identity to the rat domain of the same type IIb (90154)

   3. Species Norway rat (Rattus norvegicus) [TaxId:10116] [90154] (2 PDB entries)

5. Urokinase plasminogen activator surface receptor uPAR [161128] (1 species)
   duplication: tandem repeat of three similar domains; the N-terminal and C-terminal domains belong to Pfam PF00021; uPAR/Ly6

   • Species Human (Homo sapiens) [TaxId:9606] [161129] (1 PDB entry)
     Uniprot Q03405 109-209! Uniprot Q03405 210-299! Uniprot Q03405 23-108

6. Urokinase plasminogen activator surface receptor, UPAR [161130] (1 species)
   duplication; comprises three domains of this fold

   • Species Human (Homo sapiens) [TaxId:9606] [161131] (4 PDB entries)
     Uniprot Q03405 111-210! Uniprot Q03405 114-210! Uniprot Q03405 211-297! Uniprot Q03405 211-301! Uniprot Q03405 23-102! Uniprot Q03405 23-104

7. automated matches [190308] (2 species)
   not a true protein

   1. Species Human (Homo sapiens) [TaxId:9606] [187126] (3 PDB entries)

   2. Species Mouse (Mus musculus) [TaxId:10090] [187122] (1 PDB entry)

More info for Family g.7.1.3: Extracellular domain of cell surface receptors

Timeline for Family g.7.1.3: Extracellular domain of cell surface receptors:

• Family g.7.1.3: Extracellular domain of cell surface receptors first appeared (with stable ids) in SCOP 1.55
  
• Family g.7.1.3: Extracellular domain of cell surface receptors appears in SCOP 1.75
  
• Family g.7.1.3: Extracellular domain of cell surface receptors appears in SCOPe 2.02
  
• Family g.7.1.3: Extracellular domain of cell surface receptors appears in the current release, SCOPe 2.08