SCOPe 2.07: Family g.3.7.2: Short-chain scorpion toxins

Lineage for Family g.3.7.2: Short-chain scorpion toxins

1. Root: SCOPe 2.07

2. Class g: Small proteins [56992] (98 folds)

3. Fold g.3: Knottins (small inhibitors, toxins, lectins) [57015] (19 superfamilies)
   disulfide-bound fold; contains beta-hairpin with two adjacent disulfides

4. Superfamily g.3.7: Scorpion toxin-like [57095] (6 families)

5. Family g.3.7.2: Short-chain scorpion toxins [57116] (35 proteins)

Proteins:

1. Agitoxin [57135] (1 species)

   • Species Scorpion (Leiurus quinquestriatus hebraeus) [TaxId:6884] [57136] (1 PDB entry)

2. alpha-KTX, K+-channel blocker [64537] (2 species)

   1. Species Brazilian scorpion (Tityus serrulatus), Tstx-k alpha [TaxId:6887] [64538] (1 PDB entry)

   2. Species Scorpion (Tityus cambridgei) [TaxId:184226] [69934] (1 PDB entry)

3. Bekm-1 [82883] (1 species)

   • Species Lesser asian scorpion (Buthus eupeus) [TaxId:34648] [82884] (2 PDB entries)

4. Bmktx [57119] (1 species)

   • Species Chinese scorpion (Buthus martensii) [TaxId:34649] [57120] (1 PDB entry)

5. Bmkx [103546] (1 species)

   • Species Chinese scorpion (Buthus martensi karsch) [TaxId:34649] [103547] (2 PDB entries)

6. Bmp02 neurotoxin [57123] (1 species)

   • Species Chinese scorpion (Buthus martensii) [TaxId:34649] [57124] (1 PDB entry)

7. Bmtx1 [57117] (1 species)

   • Species Chinese scorpion (Buthus martensii) [TaxId:34649] [57118] (1 PDB entry)

8. Bmtx2 [57121] (1 species)

   • Species Chinese scorpion (Buthus martensii) [TaxId:34649] [57122] (1 PDB entry)

9. Bmtx3 [103542] (1 species)

   • Species Chinese scorpion (Buthus martensii karsch) [TaxId:34649] [103543] (1 PDB entry)

10. Butantoxin [57139] (1 species)

    • Species Brazilian scorpion (Tityus serrulatus) [TaxId:6887] [57140] (2 PDB entries)

11. Charybdotoxin [57131] (1 species)

    • Species Scorpion (Leiurus quinquestriatus hebraeus) [TaxId:6884] [57132] (5 PDB entries)

12. Chlorootoxin [57137] (2 species)

    1. Species Leiurus quinquestriatus [TaxId:6885] [337498] (1 PDB entry)

    2. Species Scorpion (Leiurus quinquestriatus), venom [TaxId:6883] [57138] (1 PDB entry)

13. Cobatoxin 1 [103552] (1 species)

    • Species Mexican scorpion (Centruroides noxius) [TaxId:6878] [103553] (1 PDB entry)

14. Ergtoxin (HERG specific toxin CnErg1) [90137] (1 species)

    • Species Mexican scorpion (Centruroides noxius) [TaxId:6878] [90138] (2 PDB entries)
      Uniprot Q86QT3 21-62

15. Hongotoxin 1 [103548] (1 species)

    • Species Scorpion (Centruroides margaritatus) [TaxId:29018] [103549] (1 PDB entry)

16. Istx [118241] (1 species)

    • Species Scorpion (Opisthacanthus madagascariensis) [TaxId:167108] [118242] (1 PDB entry)
      Uniprot Q10726 2-33 # 53% sequence identity

17. K+ toxin-like peptide Bmp07 (BmKK2) [111396] (1 species)

    • Species Chinese scorpion (Buthus martensi karsch) [TaxId:34649] [111397] (1 PDB entry)
      Uniprot Q95NK7

18. Kaliotoxin (KTX) [57151] (2 species)

    1. Species Androctonus mauretanicus [TaxId:6859] [161119] (1 PDB entry)

    2. Species Scorpion (Androctonus mauretanicus mauretanicus) [TaxId:6860] [57152] (3 PDB entries)

19. LQ2 toxin [57153] (1 species)

    • Species Scorpion (Leiurus quinquestriatus hebraeus) [TaxId:6884] [57154] (1 PDB entry)

20. Margatoxin [57125] (1 species)

    • Species Scorpion (Centruroides margaritatus) [TaxId:29018] [57126] (1 PDB entry)

21. Maurotoxin [57129] (2 species)

    1. Species Scorpio maurus palmatus [TaxId:53957] [161118] (1 PDB entry)

    2. Species Scorpion (Scorpio maurus) [TaxId:53956] [57130] (3 PDB entries)
       Uniprot P80719

22. Neurotoxin bmk37 [103544] (1 species)

    • Species Chinese scorpion (Buthus martensi karsch) [TaxId:34649] [103545] (2 PDB entries)

23. Neurotoxin bmp01 [111398] (1 species)

    • Species Chinese scorpion (Buthus martensii karsch) [TaxId:34649] [111399] (1 PDB entry)
      Uniprot Q9U8D2

24. Neurotoxin bmp03 [111400] (1 species)

    • Species Chinese scorpion (Buthus martensii karsch) [TaxId:34649] [111401] (1 PDB entry)
      Uniprot Q9U8D1

25. Noxiustoxin [57127] (1 species)

    • Species Mexican scorpion (Centruroides noxius) [TaxId:6878] [57128] (1 PDB entry)

26. OSK1 TOXIN [57149] (1 species)

    • Species Central asian scorpion (Orthochirus scrobiculosus) [TaxId:6892] [57150] (1 PDB entry)

27. Pandinus toxin [57155] (2 species)

    1. Species Emperor scorpion (Pandinus imperator), PITX-Ka [TaxId:55084] [57156] (1 PDB entry)

    2. Species Emperor scorpion (Pandinus imperator), PITX-Kb [TaxId:55084] [57157] (1 PDB entry)

28. PI4, potassium channel blocking toxin 4 [103550] (1 species)

    • Species Emperor scorpion (Pandinus imperator) [TaxId:55084] [103551] (1 PDB entry)

29. PI7 [57158] (1 species)
    nontoxic peptide?

    • Species Emperor scorpion (Pandinus imperator) [TaxId:55084] [57159] (1 PDB entry)

30. Scyllatoxin [57133] (1 species)

    • Species Scorpion (Leiurus quinquestriatus hebraeus) [TaxId:6884] [57134] (1 PDB entry)

31. Toxin analog [57145] (1 species)

    • Species Scorpion (Androctonus mauretanicus mauretanicus) [TaxId:6860] [57146] (1 PDB entry)

32. Toxin analog P01 [57147] (1 species)

    • Species Scorpion (Androctonus mauretanicus mauretanicus) [TaxId:6860] [57148] (1 PDB entry)

33. Toxin I5a [57143] (1 species)

    • Species Scorpion (Buthus eupeus) [TaxId:34648] [57144] (1 PDB entry)

34. Toxin ts kappa [57141] (1 species)

    • Species Scorpion (Tityus serrulatus) [TaxId:6887] [57142] (1 PDB entry)

35. automated matches [197331] (11 species)
    not a true protein

    1. Species Androctonus australis [TaxId:6858] [356346] (1 PDB entry)

    2. Species Buthus occitanus [TaxId:539894] [356436] (1 PDB entry)

    3. Species Emperor scorpion (Pandinus imperator) [TaxId:55084] [254955] (1 PDB entry)

    4. Species Hottentotta tamulus [TaxId:34647] [392824] (1 PDB entry)

    5. Species Leiurus quinquestriatus [TaxId:6884] [197332] (1 PDB entry)

    6. Species Mesobuthus eupeus [TaxId:34648] [349184] (1 PDB entry)

    7. Species Mesobuthus martensii [TaxId:34649] [255319] (5 PDB entries)

    8. Species Mesobuthus tamulus [TaxId:34647] [255376] (18 PDB entries)

    9. Species Opistophthalmus carinatus [TaxId:190115] [349386] (1 PDB entry)

    10. Species Tityus costatus [TaxId:309814] [349405] (1 PDB entry)

    11. Species Tityus serrulatus [TaxId:6887] [349390] (1 PDB entry)

More info for Family g.3.7.2: Short-chain scorpion toxins

Timeline for Family g.3.7.2: Short-chain scorpion toxins:

• Family g.3.7.2: Short-chain scorpion toxins first appeared (with stable ids) in SCOP 1.55
  
• Family g.3.7.2: Short-chain scorpion toxins appears in SCOPe 2.06
  
• Family g.3.7.2: Short-chain scorpion toxins appears in the current release, SCOPe 2.08