Lineage for Fold g.3: Knottins (small inhibitors, toxins, lectins)

  1. Root: SCOPe 2.02
  2. 1239924Class g: Small proteins [56992] (90 folds)
  3. 1240201Fold g.3: Knottins (small inhibitors, toxins, lectins) [57015] (19 superfamilies)
    disulfide-bound fold; contains beta-hairpin with two adjacent disulfides

Superfamilies:

  1. 1240202g.3.1: Plant lectins/antimicrobial peptides [57016] (2 families) (S)
  2. 1240330g.3.2: Plant inhibitors of proteinases and amylases [57027] (1 family) (S)
  3. 1240382g.3.3: Cyclotides [57038] (4 families) (S)
    macrocyclic plant knottins closed with the formation of an Asn-Gly peptide
  4. 1240413g.3.4: Gurmarin-like [57048] (2 families) (S)
  5. 1240426g.3.5: Agouti-related protein [57055] (1 family) (S)
  6. 1240432g.3.6: omega toxin-like [57059] (5 families) (S)
  7. 1240580g.3.7: Scorpion toxin-like [57095] (5 families) (S)
  8. 1240869g.3.8: Cellulose-binding domain [57180] (1 family) (S)
  9. 1240879g.3.9: Growth factor receptor domain [57184] (1 family) (S)
  10. 1240943g.3.10: Colipase-like [57190] (1 family) (S)
  11. 1240965g.3.11: EGF/Laminin [57196] (7 families) (S)
  12. 1241464g.3.12: Bromelain inhibitor VI (cysteine protease inhibitor) [57243] (1 family) (S)
  13. 1241472g.3.13: Bowman-Birk inhibitor, BBI [57247] (1 family) (S)
  14. 1241506g.3.14: Elafin-like [57256] (1 family) (S)
  15. 1241515g.3.15: Leech antihemostatic proteins [57262] (3 families) (S)
  16. 1241563g.3.16: Granulin repeat [57277] (1 family) (S)
  17. 1241575g.3.17: Satiety factor CART (cocaine and amphetamine regulated transcript) [64546] (1 family) (S)
  18. 1241580g.3.18: DPY module [90148] (1 family) (S)
  19. 1241585g.3.19: Bubble protein [103565] (1 family) (S)

More info for Fold g.3: Knottins (small inhibitors, toxins, lectins)

Timeline for Fold g.3: Knottins (small inhibitors, toxins, lectins):