SCOP 1.75: Protein: Insulin

Lineage for Protein: Insulin

Root: SCOP 1.75
Class g: Small proteins [56992] (90 folds)
Fold g.1: Insulin-like [56993] (1 superfamily)
nearly all-alpha
can be classified as disulfide-rich
Superfamily g.1.1: Insulin-like [56994] (1 family)
Family g.1.1.1: Insulin-like [56995] (4 proteins)
Protein Insulin [56996] (3 species)

Species:

Cow (Bos taurus) [TaxId:9913] [56997] (6 PDB entries)
1. Domain for 1aph:
  - Domain d1aph.1: 1aph B:,A: [43834]
    complexed with dce
2. Domain for 1bph:
  - Domain d1bph.1: 1bph B:,A: [43833]
    complexed with dce, na
3. Domain for 1cph:
  - Domain d1cph.1: 1cph B:,A: [43831]
    complexed with dce, na
4. Domain for 1dph:
  - Domain d1dph.1: 1dph B:,A: [43832]
    complexed with dce, na
5. Domains for 1pid:
  1. Domain d1pid.1: 1pid B:,A: [43829]
  2. Domain d1pid.2: 1pid D:,C: [43830]
6. Domains for 2ins:
  1. Domain d2ins.1: 2ins B:,A: [43835]
  2. Domain d2ins.2: 2ins D:,C: [43836]
    complexed with zn1, zn2
Human (Homo sapiens) [TaxId:9606] [56998] (60 PDB entries)
Uniprot P01308
1. Domain for 1a7f:
  - Domain d1a7f.1: 1a7f B:,A: [43943]
    mutant
2. Domains for 1ai0:
  1. Domain d1ai0.1: 1ai0 B:,A: [43924]
  2. Domain d1ai0.2: 1ai0 D:,C: [43925]
  3. Domain d1ai0.3: 1ai0 F:,E: [43926]
  4. Domain d1ai0.4: 1ai0 H:,G: [43927]
  5. Domain d1ai0.5: 1ai0 J:,I: [43928]
  6. Domain d1ai0.6: 1ai0 L:,K: [43929]
    complexed with iph, zn
3. Domains for 1aiy:
  1. Domain d1aiy.1: 1aiy B:,A: [43930]
  2. Domain d1aiy.2: 1aiy D:,C: [43931]
  3. Domain d1aiy.3: 1aiy F:,E: [43932]
  4. Domain d1aiy.4: 1aiy H:,G: [43933]
  5. Domain d1aiy.5: 1aiy J:,I: [43934]
  6. Domain d1aiy.6: 1aiy L:,K: [43935]
    complexed with iph, zn
4. Domains for 1b9e:
  1. Domain d1b9e.1: 1b9e B:,A: [43885]
  2. Domain d1b9e.2: 1b9e D:,C: [43886]
5. Domains for 1ben:
  1. Domain d1ben.1: 1ben B:,A: [43837]
  2. Domain d1ben.2: 1ben D:,C: [43838]
    complexed with cl, hbd, zn
6. Domain for 1bzv:
  - Domain d1bzv.1: 1bzv B:,A: [43942]
    superpotent single-replacement insulin analogue
    mutant
7. Domain for 1efe:
  - Domain d1efea_: 1efe A: [43891]
    an active mini-proinsulin, m2pi
8. Domains for 1ev3:
  1. Domain d1ev3.1: 1ev3 B:,A: [43845]
  2. Domain d1ev3.2: 1ev3 D:,C: [43846]
    complexed with cl, crs, zn
9. Domains for 1ev6:
  1. Domain d1ev6.1: 1ev6 B:,A: [43857]
  2. Domain d1ev6.2: 1ev6 D:,C: [43858]
  3. Domain d1ev6.3: 1ev6 F:,E: [43859]
  4. Domain d1ev6.4: 1ev6 H:,G: [43860]
  5. Domain d1ev6.5: 1ev6 J:,I: [43861]
  6. Domain d1ev6.6: 1ev6 L:,K: [43862]
    complexed with cl, crs, na, zn
10. Domains for 1evr:
  1. Domain d1evr.1: 1evr B:,A: [43851]
  2. Domain d1evr.2: 1evr D:,C: [43852]
  3. Domain d1evr.3: 1evr F:,E: [43853]
  4. Domain d1evr.4: 1evr H:,G: [43854]
  5. Domain d1evr.5: 1evr J:,I: [43855]
  6. Domain d1evr.6: 1evr L:,K: [43856]
    complexed with cl, na, rco, zn
11. Domains for 1fu2:
  1. Domain d1fu2.1: 1fu2 B:,A: [43906]
  2. Domain d1fu2.2: 1fu2 D:,C: [43907]
  3. Domain d1fu2.3: 1fu2 F:,E: [43908]
  4. Domain d1fu2.4: 1fu2 H:,G: [43909]
    complexed with cl, na, zn
12. Domains for 1fub:
  1. Domain d1fub.1: 1fub B:,A: [43892]
  2. Domain d1fub.2: 1fub D:,C: [43893]
    complexed with cl, na, zn
13. Domains for 1g7a:
  1. Domain d1g7a.1: 1g7a B:,A: [60322]
  2. Domain d1g7a.2: 1g7a D:,C: [60323]
  3. Domain d1g7a.3: 1g7a F:,E: [60324]
  4. Domain d1g7a.4: 1g7a H:,G: [60325]
    complexed with acn, cl, cry, zn
14. Domains for 1g7b:
  1. Domain d1g7b.1: 1g7b B:,A: [60326]
  2. Domain d1g7b.2: 1g7b D:,C: [60327]
  3. Domain d1g7b.3: 1g7b F:,E: [60328]
  4. Domain d1g7b.4: 1g7b H:,G: [60329]
    complexed with acn, cl, cry, zn
15. Domains for 1guj:
  1. Domain d1guj.1: 1guj B:,A: [70582]
    structure at pH 2: the conditions promoting insulin fibre formation
  2. Domain d1guj.2: 1guj D:,C: [70583]
    structure at pH 2: the conditions promoting insulin fibre formation
    complexed with so4
16. Domain for 1hiq:
  - Domain d1hiq.1: 1hiq B:,A: [43936]
    mutant
17. Domain for 1his:
  - Domain d1his.1: 1his B:,A: [43938]
18. Domain for 1hit:
  - Domain d1hit.1: 1hit B:,A: [43937]
    mutant
19. Domain for 1hls:
  - Domain d1hls.1: 1hls B:,A: [43910]
    mutant
20. Domains for 1htv:
  1. Domain d1htv.1: 1htv B:,A: [61255]
  2. Domain d1htv.2: 1htv D:,C: [61256]
  3. Domain d1htv.3: 1htv F:,E: [61257]
  4. Domain d1htv.4: 1htv H:,G: [61258]
  5. Domain d1htv.5: 1htv J:,I: [61259]
  6. Domain d1htv.6: 1htv L:,K: [61260]
    complexed with zn
21. Domain for 1hui:
  - Domain d1hui.1: 1hui B:,A: [43940]
    mutant
22. Domain for 1iog:
  - Domain d1iog.1: 1iog B:,A: [43944]
    mutant
23. Domain for 1ioh:
  - Domain d1ioh.1: 1ioh B:,A: [43941]
    mutant
24. Domains for 1j73:
  1. Domain d1j73.1: 1j73 B:,A: [62670]
    an unstable insulin analog with native activity
  2. Domain d1j73.2: 1j73 D:,C: [62671]
    an unstable insulin analog with native activity
    complexed with dab, zn; mutant
25. Domains for 1jca:
  1. Domain d1jca.1: 1jca B:,A: [62874]
    an unstable insulin analog with enhanced(?) activity
  2. Domain d1jca.2: 1jca D:,C: [62875]
    an unstable insulin analog with enhanced(?) activity
    complexed with zn; mutant
26. Domain for 1jco:
  - Domain d1jco.1: 1jco B:,A: [66503]
    a monomeric mutant (PT insulin)
    Alpha-galactosidase agl1
    mutant
27. Domain for 1k3m:
  - Domain d1k3m.1: 1k3m B:,A: [68117]
    mutant
28. Domain for 1kmf:
  - Domain d1kmf.1: 1kmf B:,A: [68694]
    mutant
29. Domain for 1lkq:
  - Domain d1lkq.1: 1lkq B:,A: [73979]
    mutant
30. Domain for 1lnp:
  - Domain d1lnp.1: 1lnp B:,A: [74048]
    mutant
31. Domains for 1lph:
  1. Domain d1lph.1: 1lph B:,A: [43887]
  2. Domain d1lph.2: 1lph D:,C: [43888]
    complexed with cl, iph, zn; mutant
32. Domain for 1mhi:
  - Domain d1mhi.1: 1mhi B:,A: [43945]
    mutant
33. Domain for 1mhj:
  - Domain d1mhj.1: 1mhj B:,A: [43947]
    mutant
34. Domains for 1mso:
  1. Domain d1mso.1: 1mso B:,A: [85092]
  2. Domain d1mso.2: 1mso D:,C: [85093]
    complexed with zn
35. Domains for 1os3:
  1. Domain d1os3.1: 1os3 B:,A: [87372]
  2. Domain d1os3.2: 1os3 D:,C: [87373]
    complexed with cl, zn
36. Domains for 1os4:
  1. Domain d1os4.1: 1os4 B:,A: [87374]
  2. Domain d1os4.2: 1os4 D:,C: [87375]
  3. Domain d1os4.3: 1os4 F:,E: [87376]
  4. Domain d1os4.4: 1os4 H:,G: [87377]
  5. Domain d1os4.5: 1os4 J:,I: [87378]
  6. Domain d1os4.6: 1os4 L:,K: [87379]
    complexed with zn
37. Domains for 1q4v:
  1. Domain d1q4v.1: 1q4v B:,A: [95830]
  2. Domain d1q4v.2: 1q4v D:,C: [95831]
    complexed with iph, zn
38. Domains for 1qiy:
  1. Domain d1qiy.1: 1qiy B:,A: [43879]
  2. Domain d1qiy.2: 1qiy D:,C: [43880]
  3. Domain d1qiy.3: 1qiy F:,E: [43881]
  4. Domain d1qiy.4: 1qiy H:,G: [43882]
  5. Domain d1qiy.5: 1qiy J:,I: [43883]
  6. Domain d1qiy.6: 1qiy L:,K: [43884]
    complexed with cl, iph, zn; mutant
39. Domains for 1qiz:
  1. Domain d1qiz.1: 1qiz B:,A: [43873]
  2. Domain d1qiz.2: 1qiz D:,C: [43874]
  3. Domain d1qiz.3: 1qiz F:,E: [43875]
  4. Domain d1qiz.4: 1qiz H:,G: [43876]
  5. Domain d1qiz.5: 1qiz J:,I: [43877]
  6. Domain d1qiz.6: 1qiz L:,K: [43878]
    complexed with cl, rco, zn; mutant
40. Domains for 1qj0:
  1. Domain d1qj0.1: 1qj0 B:,A: [43889]
  2. Domain d1qj0.2: 1qj0 D:,C: [43890]
    complexed with cl, zn; mutant
41. Domain for 1sf1:
  - Domain d1sf1.1: 1sf1 B:,A: [98827]
    solution structure under amyloidogenic condition
42. Domain for 1sjt:
  - Domain d1sjt.1: 1sjt B:,A: [43946]
    mutant
43. Domain for 1sju:
  - Domain d1sjua_: 1sju A: [43950]
    single chain insulin analog mutant
44. Domain for 1t1k:
  - Domain d1t1k.1: 1t1k B:,A: [106251]
    mutant
45. Domain for 1t1p:
  - Domain d1t1p.1: 1t1p B:,A: [106260]
    mutant
46. Domain for 1t1q:
  - Domain d1t1q.1: 1t1q B:,A: [106261]
    complexed with aba; mutant
47. Domains for 1trz:
  1. Domain d1trz.1: 1trz B:,A: [43843]
  2. Domain d1trz.2: 1trz D:,C: [43844]
    complexed with cl, na, zn
48. Domains for 1tyl:
  1. Domain d1tyl.1: 1tyl B:,A: [43865]
  2. Domain d1tyl.2: 1tyl D:,C: [43866]
    complexed with cl, tyl, zn
49. Domains for 1tym:
  1. Domain d1tym.1: 1tym B:,A: [43863]
  2. Domain d1tym.2: 1tym D:,C: [43864]
    complexed with cl, tyl, zn
50. Domain for 1vkt:
  - Domain d1vkt.1: 1vkt B:,A: [43949]
    mutant
51. Domains for 1xda:
  1. Domain d1xda.1: 1xda B:,A: [43847]
  2. Domain d1xda.2: 1xda D:,C: [43848]
  3. Domain d1xda.3: 1xda F:,E: [43849]
  4. Domain d1xda.4: 1xda H:,G: [43850]
    complexed with cl, iph, myr, zn
52. Domain for 1xgl:
  - Domain d1xgl.1: 1xgl B:,A: [43939]
53. Domains for 1zeg:
  1. Domain d1zeg.1: 1zeg B:,A: [43841]
  2. Domain d1zeg.2: 1zeg D:,C: [43842]
    complexed with cl, iph, zn; mutant
54. Domains for 1zeh:
  1. Domain d1zeh.1: 1zeh B:,A: [43839]
  2. Domain d1zeh.2: 1zeh D:,C: [43840]
    complexed with cl, crs, zn; mutant
55. Domains for 1znj:
  1. Domain d1znj.1: 1znj B:,A: [43867]
  2. Domain d1znj.2: 1znj D:,C: [43868]
  3. Domain d1znj.3: 1znj F:,E: [43869]
  4. Domain d1znj.4: 1znj H:,G: [43870]
  5. Domain d1znj.5: 1znj J:,I: [43871]
  6. Domain d1znj.6: 1znj L:,K: [43872]
    complexed with cl, iph, zn
56. Domains for 2aiy:
  1. Domain d2aiy.1: 2aiy B:,A: [43918]
  2. Domain d2aiy.2: 2aiy D:,C: [43919]
  3. Domain d2aiy.3: 2aiy F:,E: [43920]
  4. Domain d2aiy.4: 2aiy H:,G: [43921]
  5. Domain d2aiy.5: 2aiy J:,I: [43922]
  6. Domain d2aiy.6: 2aiy L:,K: [43923]
    complexed with iph
57. Domain for 2hiu:
  - Domain d2hiu.1: 2hiu B:,A: [43948]
58. Domains for 3aiy:
  1. Domain d3aiy.1: 3aiy B:,A: [43911]
  2. Domain d3aiy.2: 3aiy D:,C: [43912]
  3. Domain d3aiy.3: 3aiy F:,E: [43913]
  4. Domain d3aiy.4: 3aiy H:,G: [43914]
  5. Domain d3aiy.5: 3aiy J:,I: [43915]
  6. Domain d3aiy.6: 3aiy L:,K: [43916]
    complexed with iph
59. Domains for 4aiy:
  1. Domain d4aiy.1: 4aiy B:,A: [43900]
  2. Domain d4aiy.2: 4aiy D:,C: [43901]
  3. Domain d4aiy.3: 4aiy F:,E: [43902]
  4. Domain d4aiy.4: 4aiy H:,G: [43903]
  5. Domain d4aiy.5: 4aiy J:,I: [43904]
  6. Domain d4aiy.6: 4aiy L:,K: [43905]
    complexed with iph
60. Domains for 5aiy:
  1. Domain d5aiy.1: 5aiy B:,A: [43894]
  2. Domain d5aiy.2: 5aiy D:,C: [43895]
  3. Domain d5aiy.3: 5aiy F:,E: [43896]
  4. Domain d5aiy.4: 5aiy H:,G: [43897]
  5. Domain d5aiy.5: 5aiy J:,I: [43898]
  6. Domain d5aiy.6: 5aiy L:,K: [43899]
    complexed with iph
Pig (Sus scrofa) [TaxId:9823] [56999] (26 PDB entries)
1. Domain for 1b17:
  - Domain d1b17.1: 1b17 B:,A: [83148]
    complexed with so4
2. Domain for 1b18:
  - Domain d1b18.1: 1b18 B:,A: [83149]
    complexed with so4
3. Domain for 1b19:
  - Domain d1b19.1: 1b19 B:,A: [83150]
    complexed with so4
4. Domain for 1b2a:
  - Domain d1b2a.1: 1b2a B:,A: [83151]
    complexed with so4
5. Domain for 1b2b:
  - Domain d1b2b.1: 1b2b B:,A: [83152]
    complexed with so4
6. Domain for 1b2c:
  - Domain d1b2c.1: 1b2c B:,A: [83153]
    complexed with so4
7. Domain for 1b2d:
  - Domain d1b2d.1: 1b2d B:,A: [83154]
    complexed with so4
8. Domain for 1b2e:
  - Domain d1b2e.1: 1b2e B:,A: [83155]
    complexed with so4
9. Domain for 1b2f:
  - Domain d1b2f.1: 1b2f B:,A: [83156]
10. Domain for 1b2g:
  - Domain d1b2g.1: 1b2g B:,A: [83157]
11. Domains for 1dei:
  1. Domain d1dei.1: 1dei B:,A: [43957]
  2. Domain d1dei.2: 1dei D:,C: [43958]
    mutant
12. Domains for 1iza:
  1. Domain d1iza.1: 1iza B:,A: [43980]
  2. Domain d1iza.2: 1iza D:,C: [43981]
    mutant
13. Domains for 1izb:
  1. Domain d1izb.1: 1izb B:,A: [43971]
  2. Domain d1izb.2: 1izb D:,C: [43972]
    complexed with zn; mutant
14. Domains for 1m5a:
  1. Domain d1m5a.1: 1m5a B:,A: [74491]
  2. Domain d1m5a.2: 1m5a D:,C: [74492]
    complexed with co
15. Domains for 1mpj:
  1. Domain d1mpj.1: 1mpj B:,A: [43978]
  2. Domain d1mpj.2: 1mpj D:,C: [43979]
    complexed with cl, iph, zn
16. Domain for 1sdb:
  - Domain d1sdb.1: 1sdb B:,A: [43960]
17. Domains for 1wav:
  1. Domain d1wav.1: 1wav B:,A: [43982]
  2. Domain d1wav.2: 1wav D:,C: [43983]
  3. Domain d1wav.3: 1wav F:,E: [43984]
  4. Domain d1wav.4: 1wav H:,G: [43985]
  5. Domain d1wav.5: 1wav J:,I: [43986]
  6. Domain d1wav.6: 1wav L:,K: [43987]
    complexed with iph, zn
18. Domains for 1zei:
  1. Domain d1zeia_: 1zei A: [43963]
    cross-linked b28 asp single-chain design
  2. Domain d1zeib_: 1zei B: [43964]
    cross-linked b28 asp single-chain design
  3. Domain d1zeic_: 1zei C: [43965]
    cross-linked b28 asp single-chain design
  4. Domain d1zeid_: 1zei D: [43966]
    cross-linked b28 asp single-chain design
  5. Domain d1zeie_: 1zei E: [43967]
    cross-linked b28 asp single-chain design
  6. Domain d1zeif_: 1zei F: [43968]
    cross-linked b28 asp single-chain design
    complexed with cl, crs, zn; mutant
19. Domains for 1zni:
  1. Domain d1zni.1: 1zni B:,A: [43955]
  2. Domain d1zni.2: 1zni D:,C: [43956]
    complexed with cl, zn
20. Domains for 2tci:
  1. Domain d2tci.1: 2tci B:,A: [43961]
  2. Domain d2tci.2: 2tci D:,C: [43962]
    complexed with scn, zn
21. Domains for 3ins:
  1. Domain d3ins.1: 3ins B:,A: [43953]
  2. Domain d3ins.2: 3ins D:,C: [43954]
    complexed with zn1, zn2
22. Domains for 3mth:
  1. Domain d3mth.1: 3mth B:,A: [43969]
  2. Domain d3mth.2: 3mth D:,C: [43970]
    complexed with cl, mpb, zn
23. Domains for 4ins:
  1. Domain d4ins.1: 4ins B:,A: [43951]
  2. Domain d4ins.2: 4ins D:,C: [43952]
    complexed with zn
24. Domains for 6ins:
  1. Domain d6inse_: 6ins E: [43974]
    complexed with zn
  2. Domain d6insf_: 6ins F: [43973]
25. Domains for 7ins:
  1. Domain d7ins.1: 7ins B:,A: [43975]
  2. Domain d7ins.2: 7ins D:,C: [43976]
  3. Domain d7ins.3: 7ins F:,E: [43977]
    complexed with crs, zn
26. Domain for 9ins:
  - Domain d9ins.1: 9ins B:,A: [43959]

More info for Protein Insulin from g.1.1.1: Insulin-like

Timeline for Protein Insulin from g.1.1.1: Insulin-like:

Protein Insulin from g.1.1.1: Insulin-like first appeared (with stable ids) in SCOP 1.55
Protein Insulin from g.1.1.1: Insulin-like appears in SCOP 1.73
Protein Insulin from g.1.1.1: Insulin-like appears in SCOPe 2.01
Protein Insulin from g.1.1.1: Insulin-like appears in the current release, SCOPe 2.08