Lineage for Protein: Insulin

  1. Root: SCOPe 2.08
  2. Class g: Small proteins [56992] (100 folds)
  3. Fold g.1: Insulin-like [56993] (1 superfamily)
    nearly all-alpha
    can be classified as disulfide-rich
  4. Superfamily g.1.1: Insulin-like [56994] (1 family) (S)
  5. Family g.1.1.1: Insulin-like [56995] (5 proteins)
  6. Protein Insulin [56996] (3 species)

Species:

  1. Cow (Bos taurus) [TaxId:9913] [56997] (6 PDB entries)
    1. Domain for 1aph:
    2. Domain for 1bph:
    3. Domain for 1cph:
    4. Domain for 1dph:
    5. Domains for 1pid:
      1. Domain d1pid.1: 1pid B:,A: [43829]
      2. Domain d1pid.2: 1pid D:,C: [43830]
    6. Domains for 2ins:
      1. Domain d2ins.1: 2ins B:,A: [43835]
        complexed with zn
      2. Domain d2ins.2: 2ins D:,C: [43836]
        complexed with zn
  2. Human (Homo sapiens) [TaxId:9606] [56998] (63 PDB entries)
    Uniprot P01308
    1. Domain for 1a7f:
    2. Domains for 1ai0:
      1. Domain d1ai0.1: 1ai0 B:,A: [43924]
        complexed with iph, zn
      2. Domain d1ai0.2: 1ai0 D:,C: [43925]
        complexed with iph, zn
      3. Domain d1ai0.3: 1ai0 F:,E: [43926]
        complexed with iph, zn
      4. Domain d1ai0.4: 1ai0 H:,G: [43927]
        complexed with iph, zn
      5. Domain d1ai0.5: 1ai0 J:,I: [43928]
        complexed with iph, zn
      6. Domain d1ai0.6: 1ai0 L:,K: [43929]
        complexed with iph, zn
    3. Domains for 1aiy:
      1. Domain d1aiy.1: 1aiy B:,A: [43930]
        complexed with iph, zn
      2. Domain d1aiy.2: 1aiy D:,C: [43931]
        complexed with iph, zn
      3. Domain d1aiy.3: 1aiy F:,E: [43932]
        complexed with iph, zn
      4. Domain d1aiy.4: 1aiy H:,G: [43933]
        complexed with iph, zn
      5. Domain d1aiy.5: 1aiy J:,I: [43934]
        complexed with iph, zn
      6. Domain d1aiy.6: 1aiy L:,K: [43935]
        complexed with iph, zn
    4. Domains for 1b9e:
      1. Domain d1b9e.1: 1b9e B:,A: [43885]
        mutant
      2. Domain d1b9e.2: 1b9e D:,C: [43886]
        mutant
    5. Domains for 1ben:
      1. Domain d1ben.1: 1ben B:,A: [43837]
        complexed with cl, hbd, zn
      2. Domain d1ben.2: 1ben D:,C: [43838]
        complexed with cl, hbd, zn
    6. Domain for 1bzv:
    7. Domain for 1efe:
    8. Domains for 1ev3:
      1. Domain d1ev3.1: 1ev3 B:,A: [43845]
        complexed with cl, crs, zn
      2. Domain d1ev3.2: 1ev3 D:,C: [43846]
        complexed with cl, crs, zn
    9. Domains for 1ev6:
      1. Domain d1ev6.1: 1ev6 B:,A: [43857]
        complexed with cl, crs, na, zn
      2. Domain d1ev6.2: 1ev6 D:,C: [43858]
        complexed with cl, crs, na, zn
      3. Domain d1ev6.3: 1ev6 F:,E: [43859]
        complexed with cl, crs, na, zn
      4. Domain d1ev6.4: 1ev6 H:,G: [43860]
        complexed with cl, crs, na, zn
      5. Domain d1ev6.5: 1ev6 J:,I: [43861]
        complexed with cl, crs, na, zn
      6. Domain d1ev6.6: 1ev6 L:,K: [43862]
        complexed with cl, crs, na, zn
    10. Domains for 1evr:
      1. Domain d1evr.1: 1evr B:,A: [43851]
        complexed with cl, na, rco, zn
      2. Domain d1evr.2: 1evr D:,C: [43852]
        complexed with cl, na, rco, zn
      3. Domain d1evr.3: 1evr F:,E: [43853]
        complexed with cl, na, rco, zn
      4. Domain d1evr.4: 1evr H:,G: [43854]
        complexed with cl, na, rco, zn
      5. Domain d1evr.5: 1evr J:,I: [43855]
        complexed with cl, na, rco, zn
      6. Domain d1evr.6: 1evr L:,K: [43856]
        complexed with cl, na, rco, zn
    11. Domains for 1fu2:
      1. Domain d1fu2.1: 1fu2 B:,A: [43906]
        complexed with cl, na, zn
      2. Domain d1fu2.2: 1fu2 D:,C: [43907]
        complexed with cl, na, zn
      3. Domain d1fu2.3: 1fu2 F:,E: [43908]
        complexed with cl, na, zn
      4. Domain d1fu2.4: 1fu2 H:,G: [43909]
        complexed with cl, na, zn
    12. Domains for 1fub:
      1. Domain d1fub.1: 1fub B:,A: [43892]
        complexed with cl, na, zn
      2. Domain d1fub.2: 1fub D:,C: [43893]
        complexed with cl, na, zn
    13. Domains for 1g7a:
      1. Domain d1g7a.1: 1g7a B:,A: [60322]
        complexed with acn, cl, gol, zn
      2. Domain d1g7a.2: 1g7a D:,C: [60323]
        complexed with acn, cl, gol, zn
      3. Domain d1g7a.3: 1g7a F:,E: [60324]
        complexed with acn, cl, gol, zn
      4. Domain d1g7a.4: 1g7a H:,G: [60325]
        complexed with acn, cl, gol, zn
    14. Domains for 1g7b:
      1. Domain d1g7b.1: 1g7b B:,A: [60326]
        complexed with acn, cl, gol, zn
      2. Domain d1g7b.2: 1g7b D:,C: [60327]
        complexed with acn, cl, gol, zn
      3. Domain d1g7b.3: 1g7b F:,E: [60328]
        complexed with acn, cl, gol, zn
      4. Domain d1g7b.4: 1g7b H:,G: [60329]
        complexed with acn, cl, gol, zn
    15. Domains for 1guj:
      1. Domain d1guj.1: 1guj B:,A: [70582]
        structure at pH 2: the conditions promoting insulin fibre formation
        complexed with so4
      2. Domain d1guj.2: 1guj D:,C: [70583]
        structure at pH 2: the conditions promoting insulin fibre formation
        complexed with so4
    16. Domain for 1hiq:
    17. Domain for 1his:
    18. Domain for 1hit:
    19. Domain for 1hls:
    20. Domains for 1htv:
      1. Domain d1htv.1: 1htv B:,A: [61255]
        complexed with zn
      2. Domain d1htv.2: 1htv D:,C: [61256]
        complexed with zn
      3. Domain d1htv.3: 1htv F:,E: [61257]
        complexed with zn
      4. Domain d1htv.4: 1htv H:,G: [61258]
        complexed with zn
      5. Domain d1htv.5: 1htv J:,I: [61259]
        complexed with zn
      6. Domain d1htv.6: 1htv L:,K: [61260]
        complexed with zn
    21. Domain for 1hui:
    22. Domain for 1iog:
    23. Domain for 1ioh:
    24. Domains for 1j73:
      1. Domain d1j73.1: 1j73 B:,A: [62670]
        an unstable insulin analog with native activity
        complexed with zn
      2. Domain d1j73.2: 1j73 D:,C: [62671]
        an unstable insulin analog with native activity
        complexed with zn
    25. Domains for 1jca:
      1. Domain d1jca.1: 1jca B:,A: [62874]
        an unstable insulin analog with enhanced(?) activity
        complexed with zn
      2. Domain d1jca.2: 1jca D:,C: [62875]
        an unstable insulin analog with enhanced(?) activity
        complexed with zn
    26. Domain for 1jco:
      • Domain d1jco.1: 1jco B:,A: [66503]
        a monomeric mutant (PT insulin)
        Alpha-galactosidase agl1
        mutant
    27. Domain for 1k3m:
    28. Domain for 1kmf:
    29. Domain for 1lkq:
    30. Domains for 1lph:
      1. Domain d1lph.1: 1lph B:,A: [43887]
        complexed with cl, iph, zn
      2. Domain d1lph.2: 1lph D:,C: [43888]
        complexed with cl, iph, zn
    31. Domain for 1mhi:
    32. Domain for 1mhj:
    33. Domains for 1mso:
      1. Domain d1mso.1: 1mso B:,A: [85092]
        complexed with zn
      2. Domain d1mso.2: 1mso D:,C: [85093]
        complexed with zn
    34. Domains for 1os3:
      1. Domain d1os3.1: 1os3 B:,A: [87372]
        complexed with cl, zn
      2. Domain d1os3.2: 1os3 D:,C: [87373]
        complexed with cl, zn
    35. Domains for 1os4:
      1. Domain d1os4.1: 1os4 B:,A: [87374]
        complexed with zn
      2. Domain d1os4.2: 1os4 D:,C: [87375]
        complexed with zn
      3. Domain d1os4.3: 1os4 F:,E: [87376]
        complexed with zn
      4. Domain d1os4.4: 1os4 H:,G: [87377]
        complexed with zn
      5. Domain d1os4.5: 1os4 J:,I: [87378]
        complexed with zn
      6. Domain d1os4.6: 1os4 L:,K: [87379]
        complexed with zn
    36. Domains for 1q4v:
      1. Domain d1q4v.1: 1q4v B:,A: [95830]
        complexed with iph, zn
      2. Domain d1q4v.2: 1q4v D:,C: [95831]
        complexed with iph, zn
    37. Domains for 1qiy:
      1. Domain d1qiy.1: 1qiy B:,A: [43879]
        complexed with cl, iph, zn
      2. Domain d1qiy.2: 1qiy D:,C: [43880]
        complexed with cl, iph, zn
      3. Domain d1qiy.3: 1qiy F:,E: [43881]
        complexed with cl, iph, zn
      4. Domain d1qiy.4: 1qiy H:,G: [43882]
        complexed with cl, iph, zn
      5. Domain d1qiy.5: 1qiy J:,I: [43883]
        complexed with cl, iph, zn
      6. Domain d1qiy.6: 1qiy L:,K: [43884]
        complexed with cl, iph, zn
    38. Domains for 1qiz:
      1. Domain d1qiz.1: 1qiz B:,A: [43873]
        complexed with cl, rco, zn
      2. Domain d1qiz.2: 1qiz D:,C: [43874]
        complexed with cl, rco, zn
      3. Domain d1qiz.3: 1qiz F:,E: [43875]
        complexed with cl, rco, zn
      4. Domain d1qiz.4: 1qiz H:,G: [43876]
        complexed with cl, rco, zn
      5. Domain d1qiz.5: 1qiz J:,I: [43877]
        complexed with cl, rco, zn
      6. Domain d1qiz.6: 1qiz L:,K: [43878]
        complexed with cl, rco, zn
    39. Domains for 1qj0:
      1. Domain d1qj0.1: 1qj0 B:,A: [43889]
        complexed with cl, zn
      2. Domain d1qj0.2: 1qj0 D:,C: [43890]
        complexed with cl, zn
    40. Domain for 1sf1:
    41. Domain for 1sjt:
    42. Domain for 1sju:
    43. Domain for 1t1k:
    44. Domain for 1t1p:
    45. Domain for 1t1q:
    46. Domains for 1trz:
      1. Domain d1trz.1: 1trz B:,A: [43843]
        complexed with cl, na, zn
      2. Domain d1trz.2: 1trz D:,C: [43844]
        complexed with cl, na, zn
    47. Domains for 1tyl:
      1. Domain d1tyl.1: 1tyl B:,A: [43865]
        complexed with cl, tyl, zn
      2. Domain d1tyl.2: 1tyl D:,C: [43866]
        complexed with cl, tyl, zn
    48. Domains for 1tym:
      1. Domain d1tym.1: 1tym B:,A: [43863]
        complexed with cl, tyl, zn
      2. Domain d1tym.2: 1tym D:,C: [43864]
        complexed with cl, tyl, zn
    49. Domain for 1vkt:
    50. Domains for 1xda:
      1. Domain d1xda.1: 1xda B:,A: [43847]
        complexed with cl, iph, myr, zn
      2. Domain d1xda.2: 1xda D:,C: [43848]
        complexed with cl, iph, myr, zn
      3. Domain d1xda.3: 1xda F:,E: [43849]
        complexed with cl, iph, myr, zn
      4. Domain d1xda.4: 1xda H:,G: [43850]
        complexed with cl, iph, myr, zn
    51. Domain for 1xgl:
    52. Domains for 1zeg:
      1. Domain d1zeg.1: 1zeg B:,A: [43841]
        complexed with cl, iph, zn
      2. Domain d1zeg.2: 1zeg D:,C: [43842]
        complexed with cl, iph, zn
    53. Domains for 1zeh:
      1. Domain d1zeh.1: 1zeh B:,A: [43839]
        complexed with cl, crs, zn
      2. Domain d1zeh.2: 1zeh D:,C: [43840]
        complexed with cl, crs, zn
    54. Domains for 1znj:
      1. Domain d1znj.1: 1znj B:,A: [43867]
        complexed with cl, iph, zn
      2. Domain d1znj.2: 1znj D:,C: [43868]
        complexed with cl, iph, zn
      3. Domain d1znj.3: 1znj F:,E: [43869]
        complexed with cl, iph, zn
      4. Domain d1znj.4: 1znj H:,G: [43870]
        complexed with cl, iph, zn
      5. Domain d1znj.5: 1znj J:,I: [43871]
        complexed with cl, iph, zn
      6. Domain d1znj.6: 1znj L:,K: [43872]
        complexed with cl, iph, zn
    55. Domains for 2aiy:
      1. Domain d2aiy.1: 2aiy B:,A: [43918]
        complexed with iph
      2. Domain d2aiy.2: 2aiy D:,C: [43919]
        complexed with iph
      3. Domain d2aiy.3: 2aiy F:,E: [43920]
        complexed with iph
      4. Domain d2aiy.4: 2aiy H:,G: [43921]
        complexed with iph
      5. Domain d2aiy.5: 2aiy J:,I: [43922]
        complexed with iph
      6. Domain d2aiy.6: 2aiy L:,K: [43923]
        complexed with iph
    56. Domain for 2hiu:
    57. Domain for 2jmn:
    58. Domain for 2lwz:
    59. Domains for 3aiy:
      1. Domain d3aiy.1: 3aiy B:,A: [43911]
        complexed with iph
      2. Domain d3aiy.2: 3aiy D:,C: [43912]
        complexed with iph
      3. Domain d3aiy.3: 3aiy F:,E: [43913]
        complexed with iph
      4. Domain d3aiy.4: 3aiy H:,G: [43914]
        complexed with iph
      5. Domain d3aiy.5: 3aiy J:,I: [43915]
        complexed with iph
      6. Domain d3aiy.6: 3aiy L:,K: [43916]
        complexed with iph
    60. Domains for 4aiy:
      1. Domain d4aiy.1: 4aiy B:,A: [43900]
        complexed with iph
      2. Domain d4aiy.2: 4aiy D:,C: [43901]
        complexed with iph
      3. Domain d4aiy.3: 4aiy F:,E: [43902]
        complexed with iph
      4. Domain d4aiy.4: 4aiy H:,G: [43903]
        complexed with iph
      5. Domain d4aiy.5: 4aiy J:,I: [43904]
        complexed with iph
      6. Domain d4aiy.6: 4aiy L:,K: [43905]
        complexed with iph
    61. Domains for 5aiy:
      1. Domain d5aiy.1: 5aiy B:,A: [43894]
        complexed with iph
      2. Domain d5aiy.2: 5aiy D:,C: [43895]
        complexed with iph
      3. Domain d5aiy.3: 5aiy F:,E: [43896]
        complexed with iph
      4. Domain d5aiy.4: 5aiy H:,G: [43897]
        complexed with iph
      5. Domain d5aiy.5: 5aiy J:,I: [43898]
        complexed with iph
      6. Domain d5aiy.6: 5aiy L:,K: [43899]
        complexed with iph
    62. Domain for 5wbt:
    63. Domain for 6u46:
  3. Pig (Sus scrofa) [TaxId:9823] [56999] (26 PDB entries)
    1. Domain for 1b17:
    2. Domain for 1b18:
    3. Domain for 1b19:
    4. Domain for 1b2a:
    5. Domain for 1b2b:
    6. Domain for 1b2c:
    7. Domain for 1b2d:
    8. Domain for 1b2e:
    9. Domain for 1b2f:
    10. Domain for 1b2g:
    11. Domains for 1dei:
      1. Domain d1dei.1: 1dei B:,A: [43957]
      2. Domain d1dei.2: 1dei D:,C: [43958]
    12. Domains for 1iza:
      1. Domain d1iza.1: 1iza B:,A: [43980]
        mutant
      2. Domain d1iza.2: 1iza D:,C: [43981]
        mutant
    13. Domains for 1izb:
      1. Domain d1izb.1: 1izb B:,A: [43971]
        complexed with zn; mutant
      2. Domain d1izb.2: 1izb D:,C: [43972]
        complexed with zn; mutant
    14. Domains for 1m5a:
      1. Domain d1m5a.1: 1m5a B:,A: [74491]
        complexed with co
      2. Domain d1m5a.2: 1m5a D:,C: [74492]
        complexed with co
    15. Domains for 1mpj:
      1. Domain d1mpj.1: 1mpj B:,A: [43978]
        complexed with cl, iph, zn
      2. Domain d1mpj.2: 1mpj D:,C: [43979]
        complexed with cl, iph, zn
    16. Domain for 1sdb:
    17. Domains for 1wav:
      1. Domain d1wav.1: 1wav B:,A: [43982]
        complexed with iph, zn
      2. Domain d1wav.2: 1wav D:,C: [43983]
        complexed with iph, zn
      3. Domain d1wav.3: 1wav F:,E: [43984]
        complexed with iph, zn
      4. Domain d1wav.4: 1wav H:,G: [43985]
        complexed with iph, zn
      5. Domain d1wav.5: 1wav J:,I: [43986]
        complexed with iph, zn
      6. Domain d1wav.6: 1wav L:,K: [43987]
        complexed with iph, zn
    18. Domains for 1zei:
      1. Domain d1zeia_: 1zei A: [43963]
        cross-linked b28 asp single-chain design
        complexed with cl, crs, zn
      2. Domain d1zeib_: 1zei B: [43964]
        cross-linked b28 asp single-chain design
        complexed with cl, crs, zn
      3. Domain d1zeic_: 1zei C: [43965]
        cross-linked b28 asp single-chain design
        complexed with cl, crs, zn
      4. Domain d1zeid_: 1zei D: [43966]
        cross-linked b28 asp single-chain design
        complexed with cl, crs, zn
      5. Domain d1zeie_: 1zei E: [43967]
        cross-linked b28 asp single-chain design
        complexed with cl, crs, zn
      6. Domain d1zeif_: 1zei F: [43968]
        cross-linked b28 asp single-chain design
        complexed with cl, crs, zn
    19. Domains for 1zni:
      1. Domain d1zni.1: 1zni B:,A: [43955]
        complexed with cl, zn
      2. Domain d1zni.2: 1zni D:,C: [43956]
        complexed with cl, zn
    20. Domains for 2tci:
      1. Domain d2tci.1: 2tci B:,A: [43961]
        complexed with scn, zn
      2. Domain d2tci.2: 2tci D:,C: [43962]
        complexed with scn, zn
    21. Domains for 3ins:
      1. Domain d3ins.1: 3ins B:,A: [43953]
        complexed with dod, zn
      2. Domain d3ins.2: 3ins D:,C: [43954]
        complexed with dod, zn
    22. Domains for 3mth:
      1. Domain d3mth.1: 3mth B:,A: [43969]
        complexed with cl, mpb, zn
      2. Domain d3mth.2: 3mth D:,C: [43970]
        complexed with cl, mpb, zn
    23. Domains for 4ins:
      1. Domain d4ins.1: 4ins B:,A: [43951]
        complexed with zn
      2. Domain d4ins.2: 4ins D:,C: [43952]
        complexed with zn
    24. Domains for 6ins:
      1. Domain d6inse_: 6ins E: [43974]
        complexed with zn
      2. Domain d6insf_: 6ins F: [43973]
        complexed with zn
    25. Domains for 7ins:
      1. Domain d7ins.1: 7ins B:,A: [43975]
        complexed with crs, unk, zn
      2. Domain d7ins.2: 7ins D:,C: [43976]
        complexed with crs, unk, zn
      3. Domain d7ins.3: 7ins F:,E: [43977]
        complexed with crs, unk, zn
    26. Domain for 9ins:

More info for Protein Insulin from g.1.1.1: Insulin-like

Timeline for Protein Insulin from g.1.1.1: Insulin-like: