Lineage for Class g: Small proteins

  1. Root: SCOP 1.69
  2. 520835Class g: Small proteins [56992] (75 folds)

Folds:

  1. 520836g.1: Insulin-like [56993] (1 superfamily)
    nearly all-alpha
    can be classified as disulfide-rich
  2. 521077g.2: Toxic hairpin [57006] (3 superfamilies)
    disulfide crosslinked alpha-helical hairpin
  3. 521093g.3: Knottins (small inhibitors, toxins, lectins) [57015] (19 superfamilies)
    disulfide-bound fold; contains beta-hairpin with two adjacent disulfides
  4. 522182g.4: PMP inhibitors [57282] (1 superfamily)
    disulfide-rich fold; all-beta: 3 antiparallel strands
  5. 522202g.5: Midkine [57287] (1 superfamily)
    disulfide-rich fold; all-beta: 3 antiparallel strands
  6. 522212g.6: Amb V allergen [57295] (1 superfamily)
    disulfide-rich; alpha+beta: 3 antiparallel strands followed by a short alpha helix
  7. 522220g.7: Snake toxin-like [57301] (1 superfamily)
    disulfide-rich fold: nearly all-beta
  8. 522416g.8: BPTI-like [57361] (1 superfamily)
    disulfide-rich alpha+beta fold
  9. 522584g.9: Defensin-like [57391] (1 superfamily)
    Disulfide-rich fold, nearly all-beta
  10. 522664g.10: Hairpin loop containing domain-like [57413] (1 superfamily)
    alpha+beta fold with two crossing loops
  11. 522698g.11: Neurotoxin III (ATX III) [57418] (1 superfamily)
    disulfide-rich fold
  12. 522704g.12: LDL receptor-like module [57423] (1 superfamily)
    disulfide-rich calcium-binding fold
  13. 522732g.13: Crambin-like [57428] (1 superfamily)
    disulfide-rich alpha+beta fold
  14. 522773g.14: Kringle-like [57439] (1 superfamily)
    disulfide-rich fold; nearly all-beta
  15. 522899g.16: Trefoil/Plexin domain-like [57491] (2 superfamilies)
    disulfide-rich fold; common core is alpha+beta with two conserved disulfides
  16. 522937g.17: Cystine-knot cytokines [57500] (1 superfamily)
    disulfide-rich fold; common core is all-beta
  17. 523102g.18: Complement control module/SCR domain [57534] (1 superfamily)
    disulfide-rich all-beta fold
  18. 523289g.19: Sea anemone toxin k [57545] (1 superfamily)
    disulfide-rich all-alpha fold
  19. 523299g.20: Blood coagulation inhibitor (disintegrin) [57551] (1 superfamily)
    small disulfide-rich
  20. 523327g.21: Methylamine dehydrogenase, L chain [57560] (1 superfamily)
    disulfide-rich; nearly all-beta
  21. 523349g.22: Serine proterase inhibitors [57566] (1 superfamily)
    disulfide-rich; nearly all-beta
  22. 523372g.23: TB module/8-cys domain [57580] (1 superfamily)
    disulfide-rich; alpha+beta
  23. 523386g.24: TNF receptor-like [57585] (1 superfamily)
    duplication: consists of three similar disulfide-rich domains
  24. 523476g.25: Heparin-binding domain from vascular endothelial growth factor [57592] (1 superfamily)
    duplication: consists of two similar disulfide-rich domains, alpha+beta
  25. 523484g.26: Antifungal protein (AGAFP) [57597] (1 superfamily)
    disulfide-rich; all-beta: open barrel, 5 strands; OB-fold-like
  26. 523490g.27: Fibronectin type I module [57602] (1 superfamily)
    disulfide-rich, all-beta
  27. 523509g.28: Thyroglobulin type-1 domain [57609] (1 superfamily)
    disulfide-rich, alpha+beta
  28. 523520g.29: Type X cellulose binding domain, CBDX [57614] (1 superfamily)
    disulfide-rich, alpha+beta
  29. 523527g.30: Carboxypeptidase inhibitor [57619] (1 superfamily)
    disulfide-rich, alpha+beta
  30. 523534g.31: Invertebrate chitin-binding proteins [57624] (1 superfamily)
    disulfide-rich
  31. 523544g.32: GLA-domain [57629] (1 superfamily)
    Calcium ion-bound
  32. 523584g.33: Cholecystokinin A receptor, N-domain [57641] (1 superfamily)
    a few helical turns and a disulfide-crosslinked loop
  33. 523590g.34: HIV-1 VPU cytoplasmic domain [57646] (1 superfamily)
    a few helical turns assembled without a hydrophobic core?
  34. 523596g.35: HIPIP (high potential iron protein) [57651] (1 superfamily)
    folds around 4Fe-4S cluster
  35. 523634g.36: Ferredoxin thioredoxin reductase (FTR), catalytic beta chain [57661] (1 superfamily)
    folds around 4Fe-4S cluster
  36. 523640g.37: C2H2 and C2HC zinc fingers [57666] (1 superfamily)
    alpha+beta metal(zinc)-bound fold: beta-hairpin + alpha-helix
  37. 523808g.38: Zn2/Cys6 DNA-binding domain [57700] (1 superfamily)
    all-alpha dimetal(zinc)-bound fold
  38. 523848g.39: Glucocorticoid receptor-like (DNA-binding domain) [57715] (1 superfamily)
    alpha+beta metal(zinc)-bound fold
  39. 524089g.40: Retrovirus zinc finger-like domains [57755] (1 superfamily)
    metal(zinc)-bound fold
  40. 524121g.41: Rubredoxin-like [57769] (13 superfamilies)
    metal(zinc or iron)-bound fold; sequence contains two CX(n)C motifs, in most cases n = 2
  41. 524527g.42: Ribosomal protein L36 [57839] (1 superfamily)
    zinc-bound beta-ribbon motif
  42. 524534g.43: B-box zinc-binding domain [57844] (1 superfamily)
    zinc-bound alpha+beta motif
  43. 524540g.44: RING/U-box [57849] (1 superfamily)
    dimetal(zinc)-bound alpha+beta motif; structurally diverse
  44. 524588g.45: Pyk2-associated protein beta ARF-GAP domain [57862] (1 superfamily)
    zinc-bound alpha+beta motif
  45. 524594g.46: Metallothionein [57867] (1 superfamily)
    metal(iron)-bound fold
    duplication: consists of clear structural/sequence repeats
  46. 524635g.47: Zinc domain conserved in yeast copper-regulated transcription factors [57878] (1 superfamily)
    metal(zinc)-bound alpha+beta fold
  47. 524641g.48: Ada DNA repair protein, N-terminal domain (N-Ada 10) [57883] (1 superfamily)
    metal(zinc)-bound alpha+beta fold
  48. 524648g.49: Cysteine-rich domain [57888] (1 superfamily)
    dimetal(zinc)-bound alpha+beta fold
  49. 524678g.50: FYVE/PHD zinc finger [57902] (1 superfamily)
    dimetal(zinc)-bound alpha+beta fold
  50. 524707g.51: Zn-binding domains of ADDBP [57916] (1 superfamily)
    metal(zinc)-bound alpha+beta fold
  51. 524726g.52: Inhibitor of apoptosis (IAP) repeat [57923] (1 superfamily)
    metal(zinc)-bound alpha+beta fold
  52. 524786g.53: TAZ domain [57932] (1 superfamily)
    all-alpha fold; Zn-binding sites are in the loops connecting helices
  53. 524797g.54: DnaJ/Hsp40 cysteine-rich domain [57937] (1 superfamily)
    metal(zinc)-bound extended beta-hairpin fold
  54. 524806g.55: Cellulose docking domain, dockering [64570] (1 superfamily)
    disulfide-rich, alpha+beta
  55. 524813g.58: Pheromone ER-23 [69963] (1 superfamily)
    disulfide-rich, all-alpha
  56. 524819g.59: Zinc-binding domain of translation initiation factor 2 beta [75688] (1 superfamily)
    zinc-bound beta-ribbon motif
  57. 524827g.60: TSP-1 type 1 repeat [82894] (1 superfamily)
    disulfide-rich fold; all-beta: 3 antiparallel strands
  58. 524834g.61: Apical membrane antigen 1 [82909] (1 superfamily)
    disulfide-rich, alpha+beta
  59. 524840g.62: Cysteine-rich DNA binding domain, (DM domain) [82926] (1 superfamily)
    alpha-helical fold with two Zn-binding sites
  60. 524846g.63: Mollusk pheromone [90182] (1 superfamily)
    disulfide-rich; all-alpha
  61. 524852g.64: Somatomedin B domain [90187] (1 superfamily)
    disulfide-rich
  62. 524860g.65: Notch domain [90192] (1 superfamily)
    disulfide-rich; all-alpha; calcium-binding
  63. 524866g.66: CCCH zinc finger [90228] (1 superfamily)
    metal(zinc)-bound alpha+beta fold
  64. 524876g.67: Zinc finger domain of DNA polymerase-alpha [90233] (1 superfamily)
    Zn-binding, all-alpha fold
  65. 524884g.68: Kazal-type serine protease inhibitors [100894] (1 superfamily)
  66. 524982g.69: Plant proteinase inhibitors [100896] (1 superfamily)
    disulfide-rich small alpha+beta fold; topological similarity to the Ovomucoid domain III
  67. 525006g.70: Necrosis inducing protein 1, NIP1 [103579] (1 superfamily)
    disulfide-rich fold; all-beta; duplication: contains two structural repeats
  68. 525012g.71: Mini-collagen I, C-terminal domain [103588] (1 superfamily)
    disulfide-rich
  69. 525019g.72: SBT domain [103611] (1 superfamily)
    consist of two different zn-binding subdomains, each subdomain resembles a distorted glucocorticoid receptor-like fold
  70. 525028g.73: CCHHC domain [103636] (1 superfamily)
    metal(zinc)-bound fold
  71. 525034g.74: Sec-C motif [103641] (1 superfamily)
    metal(zinc)-bound fold
  72. 525044g.75: TSP type-3 repeat [103646] (1 superfamily)
    metal(calcium)-bound fold
  73. 525050g.76: Hormone receptor domain (HRM, Pfam 02793) [111417] (1 superfamily)
    disulfide-rich all-beta fold; contains beta sandwich of 5 strands
  74. 525056g.77: Resistin (Pfam 06954) [111422] (1 superfamily)
    disulfide-rich six-stranded beta-sandwich; jelly-roll
  75. 525075g.78: YAP1 redox domain [111429] (1 superfamily)
    bipartite cysteine-rich all-alpha domain; a single helix in the N-terminal part (chain A) is linked by disulfides to the C-terminal part (chain B) [3-helical bundle of the RuvA C-terminal domain-like fold (scop_cf 46928)

More info for Class g: Small proteins

Timeline for Class g: Small proteins: