SCOPe 2.08: Protein: Apoptosis regulator Bcl-xL

Lineage for Protein: Apoptosis regulator Bcl-xL

Root: SCOPe 2.08
Class f: Membrane and cell surface proteins and peptides [56835] (69 folds)
Fold f.1: Toxins' membrane translocation domains [56836] (5 superfamilies)
multi-helical domains of various folds which is thought to unfold in the membrane
Superfamily f.1.4: Bcl-2 inhibitors of programmed cell death [56854] (2 families)
PROVISIONAL CLASSIFICATION, based on structural similarity to the diphtheria toxin domain
Family f.1.4.1: Bcl-2 inhibitors of programmed cell death [56855] (11 proteins)
Pfam PF00452
Protein Apoptosis regulator Bcl-xL [56856] (3 species)

Species:

Human (Homo sapiens) [TaxId:9606] [56857] (51 PDB entries)

Domain for 1bxl:
- Domain d1bxla1: 1bxl A:1-209 [43396]
  Other proteins in same PDB: d1bxla2, d1bxla3
Domain for 1g5j:
- Domain d1g5ja1: 1g5j A:5-213 [43394]
  Other proteins in same PDB: d1g5ja2, d1g5ja3
  complex with peptide from Bad (CH B)
Domain for 1lxl:
- Domain d1lxla1: 1lxl A:1-209 [43395]
  Other proteins in same PDB: d1lxla2, d1lxla3
  has additional insertions and/or extensions that are not grouped together
Domain for 1maz:
- Domain d1maza_: 1maz A: [43393]
Domain for 1r2d:
- Domain d1r2da_: 1r2d A: [96864]
Domain for 1r2e:
- Domain d1r2ea1: 1r2e A:27-196 [96865]
  Other proteins in same PDB: d1r2ea2
  mutant
Domain for 1r2g:
- Domain d1r2ga_: 1r2g A: [96866]
  mutant
Domain for 1r2h:
- Domain d1r2ha_: 1r2h A: [96867]
  mutant
Domain for 1r2i:
- Domain d1r2ia_: 1r2i A: [96868]
  mutant

Domain for 1ysg:

Domain d1ysga2: 1ysg A:5-213 [123973]
Other proteins in same PDB: d1ysga3, d1ysga4
automated match to d1g5ja_
complexed with 4fc, tn1
has additional insertions and/or extensions that are not grouped together

Domain for 1ysi:

Domain d1ysia2: 1ysi A:5-213 [123974]
Other proteins in same PDB: d1ysia3, d1ysia4
automated match to d1g5ja_
complexed with n3b
has additional insertions and/or extensions that are not grouped together

Domain for 1ysn:

Domain d1ysna2: 1ysn A:5-213 [123980]
Other proteins in same PDB: d1ysna3, d1ysna4
automated match to d1g5ja_
complexed with 43b
has additional insertions and/or extensions that are not grouped together

Domain for 2b48:

Domain d2b48a1: 2b48 A:1-196 [127816]
automatically matched to d1maz__
heterogeneous fold; applies to domains that adopt a different fold than the exemplar domain but has similar sequence and number of secondary structures

Domain for 2lpc:
- Domain d2lpca1: 2lpc A:1-169 [242960]
  Other proteins in same PDB: d2lpca2
  automated match to d2o1ya1
Domain for 2me8:
- Domain d2me8a1: 2me8 A:4-212 [256422]
  Other proteins in same PDB: d2me8a2
  automated match to d1bxla_
Domain for 2me9:
- Domain d2me9a1: 2me9 A:4-212 [257935]
  Other proteins in same PDB: d2me9a2
  automated match to d1bxla_
  has additional insertions and/or extensions that are not grouped together

Domain for 2o1y:

Domain d2o1ya2: 2o1y A:5-215 [138881]
Other proteins in same PDB: d2o1ya3, d2o1ya4
automated match to d1g5ja_
complexed with 43b
has additional insertions and/or extensions that are not grouped together

Domain for 2o2m:
- Domain d2o2ma_: 2o2m A: [243290]
  automated match to d4a1ua_
  complexed with li0
Domain for 2o2n:
- Domain d2o2na_: 2o2n A: [243291]
  automated match to d4a1ua_
  complexed with liw
Domains for 2p1l:
1. Domain d2p1la_: 2p1l A: [166945]
  automated match to d1g5ja_
2. Domain d2p1lc_: 2p1l C: [166946]
  automated match to d1g5ja_
3. Domain d2p1le_: 2p1l E: [166947]
  automated match to d1g5ja_
4. Domain d2p1lg_: 2p1l G: [166948]
  automated match to d1g5ja_
Domain for 2pon:
- Domain d2ponb_: 2pon B: [149723]
  automated match to d3sp7a_
Domains for 2yxj:
1. Domain d2yxja_: 2yxj A: [170913]
  Other proteins in same PDB: d2yxjb2
  automated match to d1g5ja_
  complexed with cl, gol, n3c
2. Domain d2yxjb1: 2yxj B:27-196 [170914]
  Other proteins in same PDB: d2yxjb2
  automated match to d1g5ja_
  complexed with cl, gol, n3c
Domain for 3cva:
- Domain d3cvax1: 3cva X:27-196 [173494]
  Other proteins in same PDB: d3cvax2
  automated match to d1bxla_
  mutant
Domains for 3io8:
1. Domain d3io8a1: 3io8 A:1-197 [178474]
  Other proteins in same PDB: d3io8a2, d3io8c2
  automated match to d1g5ja_
  complexed with zn
2. Domain d3io8c1: 3io8 C:1-197 [178475]
  Other proteins in same PDB: d3io8a2, d3io8c2
  automated match to d1g5ja_
  complexed with zn
Domains for 3pl7:
1. Domain d3pl7a_: 3pl7 A: [183827]
  automated match to d1g5ja_
2. Domain d3pl7b_: 3pl7 B: [183828]
  automated match to d1g5ja_
Domains for 3qkd:
1. Domain d3qkda_: 3qkd A: [184464]
  Other proteins in same PDB: d3qkdb2
  automated match to d1g5ja_
  complexed with cl, gol, hi0
2. Domain d3qkdb1: 3qkd B:27-196 [184465]
  Other proteins in same PDB: d3qkdb2
  automated match to d1g5ja_
  complexed with cl, gol, hi0
Domain for 3sp7:
- Domain d3sp7a1: 3sp7 A:1-199 [195002]
  Other proteins in same PDB: d3sp7a2
  automated match to d2o1ya1
  complexed with 03b, act, zn
Domain for 3spf:
- Domain d3spfa1: 3spf A:1-197 [195036]
  Other proteins in same PDB: d3spfa2
  automated match to d2o1ya1
  complexed with b50, gol

Domains for 3wiz:

Domain d3wiza_: 3wiz A: [233972]
automated match to d1g5ja_
complexed with lc6, po4
heterogeneous fold; applies to domains that adopt a different fold than the exemplar domain but has similar sequence and number of secondary structures

Domain d3wizb_: 3wiz B: [233973]
automated match to d1g5ja_
complexed with lc6, po4
heterogeneous fold; applies to domains that adopt a different fold than the exemplar domain but has similar sequence and number of secondary structures

Domain for 4ehr:
- Domain d4ehra1: 4ehr A:3-196 [195229]
  Other proteins in same PDB: d4ehra2
  automated match to d2o1ya1
  complexed with 0q5, imd

Domain for 4ppi:

Domain d4ppia1: 4ppi A:85-196 [269752]
Other proteins in same PDB: d4ppia2
automated match to d2o1ya_
complexed with gol
heterogeneous fold; applies to domains that adopt a different fold than the exemplar domain but has similar sequence and number of secondary structures

Domains for 4qvx:
1. Domain d4qvxa_: 4qvx A: [275212]
  automated match to d2m03a_
  complexed with 3cq
2. Domain d4qvxb_: 4qvx B: [275211]
  automated match to d2m03a_
  complexed with 3cq
Domains for 4tuh:
1. Domain d4tuha1: 4tuh A:1-196 [260442]
  Other proteins in same PDB: d4tuha2, d4tuhb2, d4tuhc2, d4tuhf2, d4tuhg2, d4tuhh2
  automated match to d1ysga_
  complexed with 38h, act, edo
2. Domain d4tuhb1: 4tuh B:1-196 [263918]
  Other proteins in same PDB: d4tuha2, d4tuhb2, d4tuhc2, d4tuhf2, d4tuhg2, d4tuhh2
  automated match to d2o1ya_
  complexed with 38h, act, edo
3. Domain d4tuhc1: 4tuh C:1-197 [263919]
  Other proteins in same PDB: d4tuha2, d4tuhb2, d4tuhc2, d4tuhf2, d4tuhg2, d4tuhh2
  automated match to d2o1ya_
  complexed with 38h, act, edo
4. Domain d4tuhd_: 4tuh D: [263920]
  Other proteins in same PDB: d4tuha2, d4tuhb2, d4tuhc2, d4tuhf2, d4tuhg2, d4tuhh2
  automated match to d2o1ya_
  complexed with 38h, act, edo
5. Domain d4tuhe_: 4tuh E: [263921]
  Other proteins in same PDB: d4tuha2, d4tuhb2, d4tuhc2, d4tuhf2, d4tuhg2, d4tuhh2
  automated match to d2o1ya_
  complexed with 38h, act, edo
6. Domain d4tuhf1: 4tuh F:1-198 [263922]
  Other proteins in same PDB: d4tuha2, d4tuhb2, d4tuhc2, d4tuhf2, d4tuhg2, d4tuhh2
  automated match to d2o1ya_
  complexed with 38h, act, edo
7. Domain d4tuhg1: 4tuh G:1-196 [263923]
  Other proteins in same PDB: d4tuha2, d4tuhb2, d4tuhc2, d4tuhf2, d4tuhg2, d4tuhh2
  automated match to d2o1ya_
  complexed with 38h, act, edo
8. Domain d4tuhh1: 4tuh H:1-197 [263924]
  Other proteins in same PDB: d4tuha2, d4tuhb2, d4tuhc2, d4tuhf2, d4tuhg2, d4tuhh2
  automated match to d2o1ya_
  complexed with 38h, act, edo
Domains for 4z9v:
1. Domain d4z9va1: 4z9v A:1-208 [312299]
  Other proteins in same PDB: d4z9va2
  automated match to d1zy3a1
  complexed with bct, na
2. Domain d4z9vb_: 4z9v B: [312403]
  Other proteins in same PDB: d4z9va2
  automated match to d1zy3a1
  complexed with bct, na
Domains for 5b1z:
1. Domain d5b1za_: 5b1z A: [327550]
  automated match to d4z9vb_
2. Domain d5b1zb_: 5b1z B: [327567]
  automated match to d4z9vb_
Domain for 6bf2:
- Domain d6bf2a1: 6bf2 A:4-212 [341182]
  Other proteins in same PDB: d6bf2a2
  automated match to d1r2ia_
  mutant
Domain for 6qgg:
- Domain d6qgga1: 6qgg A:10-203 [371331]
  Other proteins in same PDB: d6qgga2
  automated match to d1zy3a1
  complexed with j1h
Domain for 6qgh:
- Domain d6qgha1: 6qgh A:10-217 [371333]
  Other proteins in same PDB: d6qgha2, d6qgha3
  automated match to d1zy3a1
  complexed with 1xj
Domain for 6qgj:
- Domain d6qgja_: 6qgj A: [371382]
  automated match to d1zy3a1
  complexed with j1t
Domain for 6qgk:
- Domain d6qgka_: 6qgk A: [371330]
  automated match to d1zy3a1
  complexed with act, j1q
Domains for 6rnu:
1. Domain d6rnua1: 6rnu A:27-196 [375226]
  Other proteins in same PDB: d6rnua2, d6rnub2
  automated match to d1zy3a1
  complexed with br, kbh
2. Domain d6rnub1: 6rnu B:27-196 [375193]
  Other proteins in same PDB: d6rnua2, d6rnub2
  automated match to d1zy3a1
  complexed with br, kbh
Domains for 6uvc:
1. Domain d6uvca_: 6uvc A: [403902]
  Other proteins in same PDB: d6uvcb2
  automated match to d4z9vb_
  complexed with edo, so4, xoy
2. Domain d6uvcb1: 6uvc B:1-197 [403958]
  Other proteins in same PDB: d6uvcb2
  automated match to d4z9vb_
  complexed with edo, so4, xoy
Domains for 6uvd:
1. Domain d6uvda1: 6uvd A:1-197 [403877]
  Other proteins in same PDB: d6uvda2
  automated match to d4z9vb_
  complexed with edo, so4, xou
2. Domain d6uvdb_: 6uvd B: [403901]
  Other proteins in same PDB: d6uvda2
  automated match to d4z9vb_
  complexed with edo, so4, xou
Domains for 6uve:
1. Domain d6uvea1: 6uve A:1-196 [403868]
  Other proteins in same PDB: d6uvea2
  automated match to d4z9vb_
  complexed with edo, qhv
2. Domain d6uveb_: 6uve B: [403895]
  Other proteins in same PDB: d6uvea2
  automated match to d4z9vb_
  complexed with edo, qhv
3. Domain d6uvec_: 6uve C: [403880]
  Other proteins in same PDB: d6uvea2
  automated match to d4z9vb_
  complexed with edo, qhv
Domains for 6uvf:
1. Domain d6uvfa1: 6uvf A:1-196 [403963]
  Other proteins in same PDB: d6uvfa2, d6uvfb2, d6uvfc2, d6uvfd2, d6uvfh2, d6uvfj2, d6uvfk2, d6uvfl2
  automated match to d4z9vb_
  complexed with edo, qhs, so4
2. Domain d6uvfb1: 6uvf B:1-196 [403978]
  Other proteins in same PDB: d6uvfa2, d6uvfb2, d6uvfc2, d6uvfd2, d6uvfh2, d6uvfj2, d6uvfk2, d6uvfl2
  automated match to d4z9vb_
  complexed with edo, qhs, so4
3. Domain d6uvfc1: 6uvf C:1-196 [403990]
  Other proteins in same PDB: d6uvfa2, d6uvfb2, d6uvfc2, d6uvfd2, d6uvfh2, d6uvfj2, d6uvfk2, d6uvfl2
  automated match to d4z9vb_
  complexed with edo, qhs, so4
4. Domain d6uvfd1: 6uvf D:1-196 [403907]
  Other proteins in same PDB: d6uvfa2, d6uvfb2, d6uvfc2, d6uvfd2, d6uvfh2, d6uvfj2, d6uvfk2, d6uvfl2
  automated match to d4z9vb_
  complexed with edo, qhs, so4
5. Domain d6uvfe_: 6uvf E: [403965]
  Other proteins in same PDB: d6uvfa2, d6uvfb2, d6uvfc2, d6uvfd2, d6uvfh2, d6uvfj2, d6uvfk2, d6uvfl2
  automated match to d4z9vb_
  complexed with edo, qhs, so4
6. Domain d6uvff_: 6uvf F: [403989]
  Other proteins in same PDB: d6uvfa2, d6uvfb2, d6uvfc2, d6uvfd2, d6uvfh2, d6uvfj2, d6uvfk2, d6uvfl2
  automated match to d4z9vb_
  complexed with edo, qhs, so4
7. Domain d6uvfg_: 6uvf G: [403946]
  Other proteins in same PDB: d6uvfa2, d6uvfb2, d6uvfc2, d6uvfd2, d6uvfh2, d6uvfj2, d6uvfk2, d6uvfl2
  automated match to d4z9vb_
  complexed with edo, qhs, so4
8. Domain d6uvfh1: 6uvf H:1-196 [403953]
  Other proteins in same PDB: d6uvfa2, d6uvfb2, d6uvfc2, d6uvfd2, d6uvfh2, d6uvfj2, d6uvfk2, d6uvfl2
  automated match to d4z9vb_
  complexed with edo, qhs, so4
9. Domain d6uvfi_: 6uvf I: [404093]
  Other proteins in same PDB: d6uvfa2, d6uvfb2, d6uvfc2, d6uvfd2, d6uvfh2, d6uvfj2, d6uvfk2, d6uvfl2
  automated match to d4z9vb_
  complexed with edo, qhs, so4
10. Domain d6uvfj1: 6uvf J:1-195 [404043]
  Other proteins in same PDB: d6uvfa2, d6uvfb2, d6uvfc2, d6uvfd2, d6uvfh2, d6uvfj2, d6uvfk2, d6uvfl2
  automated match to d4z9vb_
  complexed with edo, qhs, so4
11. Domain d6uvfk1: 6uvf K:1-202 [403985]
  Other proteins in same PDB: d6uvfa2, d6uvfb2, d6uvfc2, d6uvfd2, d6uvfh2, d6uvfj2, d6uvfk2, d6uvfl2
  automated match to d4z9vb_
  complexed with edo, qhs, so4
12. Domain d6uvfl1: 6uvf L:1-195 [404099]
  Other proteins in same PDB: d6uvfa2, d6uvfb2, d6uvfc2, d6uvfd2, d6uvfh2, d6uvfj2, d6uvfk2, d6uvfl2
  automated match to d4z9vb_
  complexed with edo, qhs, so4
Domains for 6uvg:
1. Domain d6uvga1: 6uvg A:1-197 [403950]
  Other proteins in same PDB: d6uvga2, d6uvgb2, d6uvgd2, d6uvgg2, d6uvgh2, d6uvgk2, d6uvgl2
  automated match to d4z9vb_
  complexed with edo, qhp, so4
2. Domain d6uvgb1: 6uvg B:1-196 [403928]
  Other proteins in same PDB: d6uvga2, d6uvgb2, d6uvgd2, d6uvgg2, d6uvgh2, d6uvgk2, d6uvgl2
  automated match to d4z9vb_
  complexed with edo, qhp, so4
3. Domain d6uvgc_: 6uvg C: [403879]
  Other proteins in same PDB: d6uvga2, d6uvgb2, d6uvgd2, d6uvgg2, d6uvgh2, d6uvgk2, d6uvgl2
  automated match to d4z9vb_
  complexed with edo, qhp, so4
4. Domain d6uvgd1: 6uvg D:1-195 [403865]
  Other proteins in same PDB: d6uvga2, d6uvgb2, d6uvgd2, d6uvgg2, d6uvgh2, d6uvgk2, d6uvgl2
  automated match to d4z9vb_
  complexed with edo, qhp, so4
5. Domain d6uvge_: 6uvg E: [403872]
  Other proteins in same PDB: d6uvga2, d6uvgb2, d6uvgd2, d6uvgg2, d6uvgh2, d6uvgk2, d6uvgl2
  automated match to d4z9vb_
  complexed with edo, qhp, so4
6. Domain d6uvgf_: 6uvg F: [404040]
  Other proteins in same PDB: d6uvga2, d6uvgb2, d6uvgd2, d6uvgg2, d6uvgh2, d6uvgk2, d6uvgl2
  automated match to d4z9vb_
  complexed with edo, qhp, so4
7. Domain d6uvgg1: 6uvg G:1-196 [403885]
  Other proteins in same PDB: d6uvga2, d6uvgb2, d6uvgd2, d6uvgg2, d6uvgh2, d6uvgk2, d6uvgl2
  automated match to d4z9vb_
  complexed with edo, qhp, so4
8. Domain d6uvgh1: 6uvg H:1-197 [403873]
  Other proteins in same PDB: d6uvga2, d6uvgb2, d6uvgd2, d6uvgg2, d6uvgh2, d6uvgk2, d6uvgl2
  automated match to d4z9vb_
  complexed with edo, qhp, so4
9. Domain d6uvgi_: 6uvg I: [403882]
  Other proteins in same PDB: d6uvga2, d6uvgb2, d6uvgd2, d6uvgg2, d6uvgh2, d6uvgk2, d6uvgl2
  automated match to d4z9vb_
  complexed with edo, qhp, so4
10. Domain d6uvgj_: 6uvg J: [403874]
  Other proteins in same PDB: d6uvga2, d6uvgb2, d6uvgd2, d6uvgg2, d6uvgh2, d6uvgk2, d6uvgl2
  automated match to d4z9vb_
  complexed with edo, qhp, so4
11. Domain d6uvgk1: 6uvg K:1-197 [403930]
  Other proteins in same PDB: d6uvga2, d6uvgb2, d6uvgd2, d6uvgg2, d6uvgh2, d6uvgk2, d6uvgl2
  automated match to d4z9vb_
  complexed with edo, qhp, so4
12. Domain d6uvgl1: 6uvg L:1-195 [403982]
  Other proteins in same PDB: d6uvga2, d6uvgb2, d6uvgd2, d6uvgg2, d6uvgh2, d6uvgk2, d6uvgl2
  automated match to d4z9vb_
  complexed with edo, qhp, so4
Domains for 6uvh:
1. Domain d6uvha1: 6uvh A:1-196 [403892]
  Other proteins in same PDB: d6uvha2
  automated match to d4z9vb_
  complexed with edo, qhj, so4
2. Domain d6uvhb_: 6uvh B: [403889]
  Other proteins in same PDB: d6uvha2
  automated match to d4z9vb_
  complexed with edo, qhj, so4
3. Domain d6uvhc_: 6uvh C: [403910]
  Other proteins in same PDB: d6uvha2
  automated match to d4z9vb_
  complexed with edo, qhj, so4
4. Domain d6uvhd_: 6uvh D: [403883]
  Other proteins in same PDB: d6uvha2
  automated match to d4z9vb_
  complexed with edo, qhj, so4
Domains for 6vwc:
1. Domain d6vwca_: 6vwc A: [392838]
  automated match to d4z9vb_
  complexed with rq7
2. Domain d6vwcb_: 6vwc B: [392839]
  automated match to d4z9vb_
  complexed with rq7
Domains for 7jgv:
1. Domain d7jgva_: 7jgv A: [398964]
  automated match to d4z9vb_
  complexed with v9s
2. Domain d7jgvb_: 7jgv B: [398967]
  automated match to d4z9vb_
  complexed with v9s
Domain for 7jgw:
- Domain d7jgwa1: 7jgw A:1-196 [398965]
  Other proteins in same PDB: d7jgwa2
  automated match to d4z9vb_
  complexed with v9s
Domains for 7lh7:
1. Domain d7lh7a_: 7lh7 A: [405519]
  automated match to d4z9vb_
  complexed with xzm
2. Domain d7lh7b_: 7lh7 B: [405553]
  automated match to d4z9vb_
  complexed with xzm

Mouse (Mus musculus) [TaxId:10090] [103423] (9 PDB entries)
1. Domain for 1pq0:
  - Domain d1pq0a_: 1pq0 A: [94985]
2. Domain for 1pq1:
  - Domain d1pq1a_: 1pq1 A: [94986]
    Other proteins in same PDB: d1pq1b_
    complexed with bim peptide, chain B
3. Domain for 3ihc:
  - Domain d3ihca_: 3ihc A: [191884]
    automated match to d1pq1a_
4. Domain for 3ihd:
  - Domain d3ihda1: 3ihd A:1-196 [211685]
    Other proteins in same PDB: d3ihda2
    automated match to d1r2da_
    mutant
5. Domains for 3ihf:
  1. Domain d3ihfa_: 3ihf A: [211686]
    automated match to d1r2da_
    mutant
  2. Domain d3ihfb_: 3ihf B: [211687]
    automated match to d1r2da_
    mutant
  3. Domain d3ihfc_: 3ihf C: [211688]
    automated match to d1r2da_
    mutant
  4. Domain d3ihfd_: 3ihf D: [211689]
    automated match to d1r2da_
    mutant
6. Domain for 3iig:
  - Domain d3iiga_: 3iig A: [211712]
    automated match to d1r2da_
    mutant
7. Domain for 3iih:
  - Domain d3iiha_: 3iih A: [191885]
    automated match to d1pq1a_
8. Domains for 3ilb:
  1. Domain d3ilba_: 3ilb A: [211817]
    automated match to d1r2da_
    mutant
  2. Domain d3ilbn_: 3ilb N: [211818]
    automated match to d1r2da_
    mutant
9. Domain for 3ilc:
  - Domain d3ilca1: 3ilc A:1-196 [211819]
    Other proteins in same PDB: d3ilca2
    automated match to d1r2da_
    mutant
Norway rat (Rattus norvegicus) [TaxId:10116] [56858] (1 PDB entry)
- Domain for 1af3:
  - Domain d1af3a_: 1af3 A: [43397]

More info for Protein Apoptosis regulator Bcl-xL from f.1.4.1: Bcl-2 inhibitors of programmed cell death

Timeline for Protein Apoptosis regulator Bcl-xL from f.1.4.1: Bcl-2 inhibitors of programmed cell death:

Protein Apoptosis regulator Bcl-xL from f.1.4.1: Bcl-2 inhibitors of programmed cell death first appeared (with stable ids) in SCOP 1.55
Protein Apoptosis regulator Bcl-xL from f.1.4.1: Bcl-2 inhibitors of programmed cell death appears in SCOPe 2.07