Lineage for Family f.1.4.1: Bcl-2 inhibitors of programmed cell death

  1. Root: SCOPe 2.01
  2. 1058004Class f: Membrane and cell surface proteins and peptides [56835] (57 folds)
  3. 1058005Fold f.1: Toxins' membrane translocation domains [56836] (5 superfamilies)
    multi-helical domains of various folds which is thought to unfold in the membrane
  4. 1058045Superfamily f.1.4: Bcl-2 inhibitors of programmed cell death [56854] (1 family) (S)
    PROVISIONAL CLASSIFICATION, based on structural similarity to the diphtheria toxin domain
  5. 1058046Family f.1.4.1: Bcl-2 inhibitors of programmed cell death [56855] (11 proteins)
    Pfam PF00452

Proteins:

  1. 1058047Apoptosis regulator Bcl-w [90103] (1 species)
  2. 1058052Apoptosis regulator Bcl-xL [56856] (3 species)
    1. 1058053Species Human (Homo sapiens) [TaxId:9606] [56857] (21 PDB entries)
    2. 1058082Species Mouse (Mus musculus) [TaxId:10090] [103423] (2 PDB entries)
    3. 1058085Species Norway rat (Rattus norvegicus) [TaxId:10116] [56858] (1 PDB entry)
  3. 1058087Apoptosis regulator ced-9 [103424] (1 species)
  4. 1058094Bcl-2 [64524] (1 species)
  5. 1058101Bcl-2 homolog [75637] (1 species)
  6. 1058104Bcl-2 homolog V-bcl-2 [144081] (1 species)
  7. 1058111Early antigen protein R [103426] (1 species)
  8. 1058114EAT/MCL-1 (Myeloid cell leukemia sequence 1) [118212] (3 species)
    1. 1058115Species Human (Homo sapiens) [TaxId:9606] [188549] (1 PDB entry)
    2. 1058117Species Mouse (Mus musculus) [TaxId:10090] [118213] (5 PDB entries)
      Uniprot P97287 152-308
    3. 1058123Species Norway rat (Rattus norvegicus) [TaxId:10116] [187917] (2 PDB entries)
  9. 1058126Proapoptotic molecule Bax [56862] (1 species)
  10. 1058130Proapoptotic molecule Bid [56859] (2 species)
    1. 1058131Species Human (Homo sapiens) [TaxId:9606] [56860] (1 PDB entry)
    2. 1058133Species Mouse (Mus musculus) [TaxId:10090] [56861] (1 PDB entry)
  11. 1058135automated matches [190236] (2 species)
    not a true protein
    1. 1058136Species Human (Homo sapiens) [TaxId:9606] [188722] (14 PDB entries)
    2. 1058163Species Mouse (Mus musculus) [TaxId:10090] [187004] (1 PDB entry)

More info for Family f.1.4.1: Bcl-2 inhibitors of programmed cell death

Timeline for Family f.1.4.1: Bcl-2 inhibitors of programmed cell death: