Lineage for Family f.1.4.1: Bcl-2 inhibitors of programmed cell death

  1. Root: SCOP 1.75
  2. 886031Class f: Membrane and cell surface proteins and peptides [56835] (58 folds)
  3. 886032Fold f.1: Toxins' membrane translocation domains [56836] (5 superfamilies)
    multi-helical domains of various folds which is thought to unfold in the membrane
  4. 886072Superfamily f.1.4: Bcl-2 inhibitors of programmed cell death [56854] (1 family) (S)
    PROVISIONAL CLASSIFICATION, based on structural similarity to the diphtheria toxin domain
  5. 886073Family f.1.4.1: Bcl-2 inhibitors of programmed cell death [56855] (10 proteins)
    Pfam PF00452

Proteins:

  1. 886074Apoptosis regulator Bcl-w [90103] (1 species)
  2. 886079Apoptosis regulator Bcl-xL [56856] (3 species)
    1. 886080Species Human (Homo sapiens) [TaxId:9606] [56857] (15 PDB entries)
    2. 886096Species Mouse (Mus musculus) [TaxId:10090] [103423] (3 PDB entries)
    3. 886100Species Rat (Rattus norvegicus) [TaxId:10116] [56858] (1 PDB entry)
  3. 886102Apoptosis regulator ced-9 [103424] (1 species)
  4. 886109Bcl-2 [64524] (1 species)
  5. 886116Bcl-2 homolog [75637] (1 species)
  6. 886119Bcl-2 homolog V-bcl-2 [144081] (1 species)
  7. 886126Early antigen protein R [103426] (1 species)
  8. 886129EAT/MCL-1 (Myeloid cell leukemia sequence 1) [118212] (1 species)
  9. 886135Proapoptotic molecule Bax [56862] (1 species)
  10. 886139Proapoptotic molecule Bid [56859] (2 species)
    1. 886140Species Human (Homo sapiens) [TaxId:9606] [56860] (1 PDB entry)
    2. 886142Species Mouse (Mus musculus) [TaxId:10090] [56861] (1 PDB entry)

More info for Family f.1.4.1: Bcl-2 inhibitors of programmed cell death

Timeline for Family f.1.4.1: Bcl-2 inhibitors of programmed cell death: