SCOPe 2.01: Superfamily c.108.1: HAD-like

Lineage for Superfamily c.108.1: HAD-like

1. Root: SCOPe 2.01

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.108: HAD-like [56783] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456

4. Superfamily c.108.1: HAD-like [56784] (26 families)
   usually contains an insertion (sub)domain after strand 1

Families:

1. c.108.1.1: HAD-related [56785] (3 proteins)
   the insertion subdomain is a 4-helical bundle

2. c.108.1.2: YihX-like [56789] (2 proteins)
   the insertion subdomain is a 4-helical bundle

3. c.108.1.3: Phosphonoacetaldehyde hydrolase-like [56792] (3 proteins)
   the insertion subdomain is a 4-helical bundle

4. c.108.1.4: Phosphoserine phosphatase [64511] (1 protein)
   the insertion subdomain is a 4-helical bundle

5. c.108.1.5: Probable phosphatase YrbI [69467] (1 protein)
   the insertion subdomain is a beta-hairpin involved into tetramerisation

6. c.108.1.6: beta-Phosphoglucomutase-like [75173] (10 proteins)
   the insertion subdomain is a 4-helical bundle

7. c.108.1.7: Meta-cation ATPase, catalytic domain P [81656] (2 proteins)
   interrupted by a large insertion, domain N

8. c.108.1.8: 5'(3')-deoxyribonucleotidase (dNT-2) [82382] (2 proteins)
   the insertion subdomain is a 4-helical bundle; dephosphorylates dUMP and dTMP

9. c.108.1.9: phosphatase domain of polynucleotide kinase [82385] (2 proteins)
   no insertion subdomains

10. c.108.1.10: Predicted hydrolases Cof [82388] (12 proteins)
    contains an alpha+beta subdomain inserted into a new site after strand 3

11. c.108.1.11: Homoserine kinase ThrH [102304] (1 protein)
    the insertion subdomain is a rudiment 4-helical bundle

12. c.108.1.12: Class B acid phosphatase, AphA [102307] (1 protein)
    the insertion subdomain is a helical hairpin

13. c.108.1.13: Hypothetical protein MW1667 (SA1546) [102310] (1 protein)
    the insertion subdomain is multi-helical

14. c.108.1.14: NagD-like [102317] (7 proteins)
    duplication: consists of two segment-swapped domains of this fold; this results in the insertion of a circularly permuted domain after strand 3, analogously to the Cof family

15. c.108.1.15: Trehalose-phosphatase [110506] (1 protein)
    Pfam PF02358; contains an insert alpha+beta subdomain; similar overall fold to the Cof family

16. c.108.1.16: NLI interacting factor-like phosphatase [110509] (2 proteins)
    Pfam PF03031; NIF; the insertion subdomain is a 3-stranded beta-sheet;

17. c.108.1.17: Magnesium-dependent phosphatase-1, Mdp1 [117509] (1 protein)
    the insertion subdomain is a 3-stranded beta-sheet different from the NIF family

18. c.108.1.18: Hypothetical protein VC0232 [117512] (1 protein)
    contains a deletion in the common fold; segment-swapped tetramer

19. c.108.1.19: Histidinol phosphatase-like [142177] (3 proteins)
    no insertion subdomains

20. c.108.1.20: MtnX-like [142180] (1 protein)
    Pfam PF06888; the insertion subdomain is a rudiment 4-helical bundle

21. c.108.1.21: Pyrimidine 5'-nucleotidase (UMPH-1) [142183] (2 proteins)
    Pfam PF05822; the insertion subdomain is a rudiment 4-helical bundle

22. c.108.1.22: Enolase-phosphatase E1 [142186] (3 proteins)
    the insertion subdomain is a 4-helical bundle

23. c.108.1.23: 5' nucleotidase-like [142191] (1 protein)
    Pfam PF05761; the insertion domain cosists of 3-helical bundle and a pseudo beta-barrel; contains extra C-terminal long alpha hairpin subdomain (46556)

24. c.108.1.24: AF1437-like [159537] (1 protein)
    the insertion subdomain is a rudiment 4-helical bundle; extra alpha-hairpin insertion after strand 3

25. c.108.1.25: BT0820-like [159540] (1 protein)
    PfamB PB073209; deletion in the common fold; segment-swapped dimer

26. c.108.1.0: automated matches [191369] (1 protein)
    not a true family

More info for Superfamily c.108.1: HAD-like

Timeline for Superfamily c.108.1: HAD-like:

• Superfamily c.108.1: HAD-like first appeared (with stable ids) in SCOP 1.55, called Superfamily e.21.1: HAD-like
  
• Superfamily c.108.1: HAD-like appears in SCOP 1.75
  
• Superfamily c.108.1: HAD-like appears in SCOPe 2.02
  
• Superfamily c.108.1: HAD-like appears in the current release, SCOPe 2.08