Lineage for Superfamily c.108.1: HAD-like

  1. Root: SCOP 1.71
  2. 570216Class c: Alpha and beta proteins (a/b) [51349] (134 folds)
  3. 594610Fold c.108: HAD-like [56783] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456
  4. 594611Superfamily c.108.1: HAD-like [56784] (18 families) (S)
    usually contains an insertion (sub)domain after strand 1

Families:

  1. 594612c.108.1.1: L-2-Haloacid dehalogenase, HAD [56785] (1 protein)
    the insertion subdomain is a 4-helical bundle
  2. 594628c.108.1.2: Epoxide hydrolase, N-terminal domain [56789] (1 protein)
    the insertion subdomain is a 4-helical bundle
  3. 594642c.108.1.3: Phosphonoacetaldehyde hydrolase [56792] (1 protein)
    the insertion subdomain is a 4-helical bundle
  4. 594663c.108.1.4: Phosphoserine phosphatase [64511] (1 protein)
    the insertion subdomain is a 4-helical bundle
  5. 594685c.108.1.5: Probable phosphatase YrbI [69467] (1 protein)
    the insertion subdomain is a beta-hairpin involved into tetramerisation
  6. 594704c.108.1.6: beta-Phosphoglucomutase-like [75173] (2 proteins)
    the insertion subdomain is a 4-helical bundle
  7. 594715c.108.1.7: Calcium ATPase, catalytic domain P [81656] (1 protein)
    interrupted by a large insertion, domain N
  8. 594732c.108.1.8: 5'(3')-deoxyribonucleotidase (dNT-2) [82382] (1 protein)
    the insertion subdomain is a 4-helical bundle; dephosphorylates dUMP and dTMP
  9. 594738c.108.1.9: Polynucleotide kinase, phosphatase domain [82385] (1 protein)
    no insertion subdomains
  10. 594745c.108.1.10: Predicted hydrolases Cof [82388] (6 proteins)
    contains an alpha+beta subdomain inserted into a new site after strand 3
  11. 594785c.108.1.11: Homoserine kinase ThrH [102304] (1 protein)
    the insertion subdomain is a rudiment 4-helical bundle
  12. 594792c.108.1.12: Class B acid phosphatase [102307] (1 protein)
    the insertion subdomain is a helical hairpin
  13. 594810c.108.1.13: Hypothetical protein MW1667 (SA1546) [102310] (1 protein)
    the insertion subdomain is multi-helical
  14. 594814c.108.1.14: NagD-like [102317] (2 proteins)
    duplication: consists of two segment-swapped domains of this fold; this results in the insertion of a circularly permuted domain after strand 3, analogously to the Cof family
  15. 594825c.108.1.15: Trehalose-phosphatase [110506] (1 protein)
    Pfam 02358; contains an insert alpha+beta subdomain; similar overall fold to the Cof family
  16. 594829c.108.1.16: NLI interacting factor-like phosphatase [110509] (1 protein)
    Pfam 03031; NIF; the insertion subdomain is a 3-stranded beta-sheet;
  17. 594834c.108.1.17: Magnesium-dependent phosphatase-1, Mdp1 [117509] (1 protein)
    the insertion subdomain is a 3-stranded beta-sheet different from the NIF family
  18. 594842c.108.1.18: Hypothetical protein VC0232 [117512] (1 protein)
    contains a deletion in the common fold; segment-swapped tetramer

More info for Superfamily c.108.1: HAD-like

Timeline for Superfamily c.108.1: HAD-like: