SCOP 1.69: Superfamily c.108.1: HAD-like

Lineage for Superfamily c.108.1: HAD-like

1. Root: SCOP 1.69

2. Class c: Alpha and beta proteins (a/b) [51349] (136 folds)

3. Fold c.108: HAD-like [56783] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456

4. Superfamily c.108.1: HAD-like [56784] (16 families)
   contains an insert alpha+beta subdomain; similar overall fold to the Cof family
   usually contains an insertion (sub)domain after strand 1

Families:

1. c.108.1.1: L-2-Haloacid dehalogenase, HAD [56785] (1 protein)
   the insertion subdomain is a 4-helical bundle

2. c.108.1.2: Epoxide hydrolase, N-terminal domain [56789] (1 protein)
   the insertion subdomain is a 4-helical bundle

3. c.108.1.3: Phosphonoacetaldehyde hydrolase [56792] (1 protein)
   the insertion subdomain is a 4-helical bundle

4. c.108.1.4: Phosphoserine phosphatase [64511] (1 protein)
   the insertion subdomain is a 4-helical bundle

5. c.108.1.5: Probable phosphatase YrbI [69467] (1 protein)
   the insertion subdomain is a beta-hairpin involved into tetramerisation

6. c.108.1.6: beta-Phosphoglucomutase-like [75173] (2 proteins)
   the insertion subdomain is a 4-helical bundle

7. c.108.1.7: Calcium ATPase, catalytic domain P [81656] (1 protein)
   interrupted by a large insertion, domain N

8. c.108.1.8: 5'(3')-deoxyribonucleotidase (dNT-2) [82382] (1 protein)
   the insertion subdomain is a 4-helical bundle; dephosphorylates dUMP and dTMP

9. c.108.1.9: Polynucleotide kinase, phosphatase domain [82385] (1 protein)
   no insertion subdomains

10. c.108.1.10: Predicted hydrolases Cof [82388] (4 proteins)
    contains an alpha+beta subdomain inserted into a new site after strand 3

11. c.108.1.11: Homoserine kinase ThrH [102304] (1 protein)
    the insertion subdomain is a rudiment 4-helical bundle

12. c.108.1.12: Class B acid phosphatase [102307] (1 protein)
    the insertion subdomain is a helical hairpin

13. c.108.1.13: Hypothetical protein MW1667 (SA1546) [102310] (1 protein)
    the insertion subdomain is multi-helical

14. c.108.1.14: NagD-like [102317] (1 protein)
    contains an alpha/beta subdomain inserted after strand 3 (analogous to the Cof family)

15. c.108.1.15: Trehalose-phosphatas (Pfam 02358) [110506] (1 protein)

16. c.108.1.16: NLI interacting factor-like phosphatase (NIF, Pfam 03031) [110509] (1 protein)
    the insertion subdomain is a 3-stranded beta-sheet;

More info for Superfamily c.108.1: HAD-like

Timeline for Superfamily c.108.1: HAD-like:

• Superfamily c.108.1: HAD-like first appeared (with stable ids) in SCOP 1.55, called Superfamily e.21.1: HAD-like
  
• Superfamily c.108.1: HAD-like appears in SCOP 1.67
  
• Superfamily c.108.1: HAD-like appears in SCOP 1.71
  
• Superfamily c.108.1: HAD-like appears in the current release, SCOPe 2.08