Lineage for Superfamily c.108.1: HAD-like

  1. Root: SCOP 1.69
  2. 473232Class c: Alpha and beta proteins (a/b) [51349] (136 folds)
  3. 495850Fold c.108: HAD-like [56783] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456
  4. 495851Superfamily c.108.1: HAD-like [56784] (16 families) (S)
    contains an insert alpha+beta subdomain; similar overall fold to the Cof family
    usually contains an insertion (sub)domain after strand 1

Families:

  1. 495852c.108.1.1: L-2-Haloacid dehalogenase, HAD [56785] (1 protein)
    the insertion subdomain is a 4-helical bundle
  2. 495868c.108.1.2: Epoxide hydrolase, N-terminal domain [56789] (1 protein)
    the insertion subdomain is a 4-helical bundle
  3. 495882c.108.1.3: Phosphonoacetaldehyde hydrolase [56792] (1 protein)
    the insertion subdomain is a 4-helical bundle
  4. 495899c.108.1.4: Phosphoserine phosphatase [64511] (1 protein)
    the insertion subdomain is a 4-helical bundle
  5. 495921c.108.1.5: Probable phosphatase YrbI [69467] (1 protein)
    the insertion subdomain is a beta-hairpin involved into tetramerisation
  6. 495940c.108.1.6: beta-Phosphoglucomutase-like [75173] (2 proteins)
    the insertion subdomain is a 4-helical bundle
  7. 495951c.108.1.7: Calcium ATPase, catalytic domain P [81656] (1 protein)
    interrupted by a large insertion, domain N
  8. 495962c.108.1.8: 5'(3')-deoxyribonucleotidase (dNT-2) [82382] (1 protein)
    the insertion subdomain is a 4-helical bundle; dephosphorylates dUMP and dTMP
  9. 495968c.108.1.9: Polynucleotide kinase, phosphatase domain [82385] (1 protein)
    no insertion subdomains
  10. 495975c.108.1.10: Predicted hydrolases Cof [82388] (4 proteins)
    contains an alpha+beta subdomain inserted into a new site after strand 3
  11. 495994c.108.1.11: Homoserine kinase ThrH [102304] (1 protein)
    the insertion subdomain is a rudiment 4-helical bundle
  12. 496001c.108.1.12: Class B acid phosphatase [102307] (1 protein)
    the insertion subdomain is a helical hairpin
  13. 496007c.108.1.13: Hypothetical protein MW1667 (SA1546) [102310] (1 protein)
    the insertion subdomain is multi-helical
  14. 496011c.108.1.14: NagD-like [102317] (1 protein)
    contains an alpha/beta subdomain inserted after strand 3 (analogous to the Cof family)
  15. 496016c.108.1.15: Trehalose-phosphatas (Pfam 02358) [110506] (1 protein)
  16. 496020c.108.1.16: NLI interacting factor-like phosphatase (NIF, Pfam 03031) [110509] (1 protein)
    the insertion subdomain is a 3-stranded beta-sheet;

More info for Superfamily c.108.1: HAD-like

Timeline for Superfamily c.108.1: HAD-like: