SCOP 1.63: Superfamily c.108.1: HAD-like

Lineage for Superfamily c.108.1: HAD-like

1. Root: SCOP 1.63

2. Class c: Alpha and beta proteins (a/b) [51349] (117 folds)

3. Fold c.108: HAD-like [56783] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456

4. Superfamily c.108.1: HAD-like [56784] (10 families)
   usually contains an insertion (sub)domain after strand 1

Families:

1. c.108.1.1: L-2-Haloacid dehalogenase, HAD [56785] (1 protein)
   the insertion subdomain is a 4-helical bundle

2. c.108.1.2: Epoxide hydrolase, N-terminal domain [56789] (1 protein)
   the insertion subdomain is a 4-helical bundle

3. c.108.1.3: Phosphonoacetaldehyde hydrolase [56792] (1 protein)
   the insertion subdomain is a 4-helical bundle

4. c.108.1.4: Phosphoserine phosphatase [64511] (1 protein)
   the insertion subdomain is a 4-helical bundle

5. c.108.1.5: Probable phosphatase YrbI [69467] (1 protein)
   the insertion subdomain is a beta-hairpin involved into tetramerisation

6. c.108.1.6: beta-Phosphoglucomutase [75173] (1 protein)

7. c.108.1.7: Calcium ATPase, catalytic domain P [81656] (1 protein)
   interrupted by a large insertion, domain N

8. c.108.1.8: 5'(3')-deoxyribonucleotidase (dNT-2) [82382] (1 protein)
   the insertion subdomain is a 4-helical bundle; dephosphorylates dUMP and dTMP

9. c.108.1.9: Polynucleotide kinase, phosphatase domain [82385] (1 protein)
   no insertion subdomains

10. c.108.1.10: Predicted hydrolases Cof [82388] (1 protein)
    contains an alpha+beta subdomain inserted into a new site after strand 3

More info for Superfamily c.108.1: HAD-like

Timeline for Superfamily c.108.1: HAD-like:

• Superfamily c.108.1: HAD-like first appeared (with stable ids) in SCOP 1.55, called Superfamily e.21.1: HAD-like
  
• Superfamily c.108.1: HAD-like appears in SCOP 1.61
  
• Superfamily c.108.1: HAD-like appears in SCOP 1.65
  
• Superfamily c.108.1: HAD-like appears in the current release, SCOPe 2.08