Lineage for Superfamily c.108.1: HAD-like

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2148571Fold c.108: HAD-like [56783] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456
  4. 2148572Superfamily c.108.1: HAD-like [56784] (26 families) (S)
    usually contains an insertion (sub)domain after strand 1

Families:

  1. 2148573c.108.1.1: HAD-related [56785] (3 protein domains)
    the insertion subdomain is a 4-helical bundle
  2. 2148596c.108.1.2: YihX-like [56789] (3 protein domains)
    the insertion subdomain is a 4-helical bundle
    automatically mapped to Pfam PF13419
  3. 2148701c.108.1.3: Phosphonoacetaldehyde hydrolase-like [56792] (3 protein domains)
    the insertion subdomain is a 4-helical bundle
  4. 2148733c.108.1.4: Phosphoserine phosphatase [64511] (1 protein)
    the insertion subdomain is a 4-helical bundle
    automatically mapped to Pfam PF06888
    automatically mapped to Pfam PF12710
  5. 2148755c.108.1.5: Probable phosphatase YrbI [69467] (1 protein)
    the insertion subdomain is a beta-hairpin involved into tetramerisation
  6. 2148774c.108.1.6: beta-Phosphoglucomutase-like [75173] (10 protein domains)
    the insertion subdomain is a 4-helical bundle
  7. 2148839c.108.1.7: Meta-cation ATPase, catalytic domain P [81656] (3 protein domains)
    interrupted by a large insertion, domain N
  8. 2148920c.108.1.8: 5'(3')-deoxyribonucleotidase (dNT-2) [82382] (2 protein domains)
    the insertion subdomain is a 4-helical bundle; dephosphorylates dUMP and dTMP
    automatically mapped to Pfam PF06941
  9. 2148952c.108.1.9: phosphatase domain of polynucleotide kinase [82385] (2 protein domains)
    no insertion subdomains
  10. 2148975c.108.1.10: Predicted hydrolases Cof [82388] (12 protein domains)
    contains an alpha+beta subdomain inserted into a new site after strand 3
  11. 2149066c.108.1.11: Homoserine kinase ThrH [102304] (1 protein)
    the insertion subdomain is a rudiment 4-helical bundle
    automatically mapped to Pfam PF12710
  12. 2149073c.108.1.12: Class B acid phosphatase, AphA [102307] (1 protein)
    the insertion subdomain is a helical hairpin
    automatically mapped to Pfam PF03767
  13. 2149119c.108.1.13: Hypothetical protein MW1667 (SA1546) [102310] (1 protein)
    the insertion subdomain is multi-helical
  14. 2149123c.108.1.14: NagD-like [102317] (7 protein domains)
    duplication: consists of two segment-swapped domains of this fold; this results in the insertion of a circularly permuted domain after strand 3, analogously to the Cof family
  15. 2149151c.108.1.15: Trehalose-phosphatase [110506] (1 protein)
    Pfam PF02358; contains an insert alpha+beta subdomain; similar overall fold to the Cof family
  16. 2149155c.108.1.16: NLI interacting factor-like phosphatase [110509] (2 protein domains)
    Pfam PF03031; NIF; the insertion subdomain is a 3-stranded beta-sheet;
  17. 2149186c.108.1.17: Magnesium-dependent phosphatase-1, Mdp1 [117509] (2 protein domains)
    the insertion subdomain is a 3-stranded beta-sheet different from the NIF family
    automatically mapped to Pfam PF03031
    automatically mapped to Pfam PF12689
  18. 2149197c.108.1.18: Hypothetical protein VC0232 [117512] (1 protein)
    contains a deletion in the common fold; segment-swapped tetramer
  19. 2149204c.108.1.19: Histidinol phosphatase-like [142177] (3 protein domains)
    no insertion subdomains
  20. 2149234c.108.1.20: MtnX-like [142180] (1 protein)
    Pfam PF06888; the insertion subdomain is a rudiment 4-helical bundle
  21. 2149239c.108.1.21: Pyrimidine 5'-nucleotidase (UMPH-1) [142183] (2 protein domains)
    Pfam PF05822; the insertion subdomain is a rudiment 4-helical bundle
  22. 2149266c.108.1.22: Enolase-phosphatase E1 [142186] (3 protein domains)
    the insertion subdomain is a 4-helical bundle
  23. 2149279c.108.1.23: 5' nucleotidase-like [142191] (1 protein)
    Pfam PF05761; the insertion domain cosists of 3-helical bundle and a pseudo beta-barrel; contains extra C-terminal long alpha hairpin subdomain (46556)
  24. 2149289c.108.1.24: AF1437-like [159537] (1 protein)
    the insertion subdomain is a rudiment 4-helical bundle; extra alpha-hairpin insertion after strand 3
  25. 2149293c.108.1.25: BT0820-like [159540] (1 protein)
    PfamB PB073209; deletion in the common fold; segment-swapped dimer
  26. 2149297c.108.1.0: automated matches [191369] (1 protein)
    not a true family

More info for Superfamily c.108.1: HAD-like

Timeline for Superfamily c.108.1: HAD-like: