SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Superfamily c.108.1: HAD-like

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2148571Fold c.108: HAD-like [56783] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456
  4. 2148572Superfamily c.108.1: HAD-like [56784] (26 families) (S)
    usually contains an insertion (sub)domain after strand 1

Families:

  1. 2148573c.108.1.1: HAD-related [56785] (3 protein domains)
    the insertion subdomain is a 4-helical bundle
  2. 2148596c.108.1.2: YihX-like [56789] (3 protein domains)
    the insertion subdomain is a 4-helical bundle
    automatically mapped to Pfam PF13419
  3. 2148701c.108.1.3: Phosphonoacetaldehyde hydrolase-like [56792] (3 protein domains)
    the insertion subdomain is a 4-helical bundle
  4. 2148733c.108.1.4: Phosphoserine phosphatase [64511] (1 protein)
    the insertion subdomain is a 4-helical bundle
    automatically mapped to Pfam PF06888
    automatically mapped to Pfam PF12710
  5. 2148755c.108.1.5: Probable phosphatase YrbI [69467] (1 protein)
    the insertion subdomain is a beta-hairpin involved into tetramerisation
  6. 2148774c.108.1.6: beta-Phosphoglucomutase-like [75173] (10 protein domains)
    the insertion subdomain is a 4-helical bundle
  7. 2148839c.108.1.7: Meta-cation ATPase, catalytic domain P [81656] (3 protein domains)
    interrupted by a large insertion, domain N
  8. 2148920c.108.1.8: 5'(3')-deoxyribonucleotidase (dNT-2) [82382] (2 protein domains)
    the insertion subdomain is a 4-helical bundle; dephosphorylates dUMP and dTMP
    automatically mapped to Pfam PF06941
  9. 2148952c.108.1.9: phosphatase domain of polynucleotide kinase [82385] (2 protein domains)
    no insertion subdomains
  10. 2148975c.108.1.10: Predicted hydrolases Cof [82388] (12 protein domains)
    contains an alpha+beta subdomain inserted into a new site after strand 3
  11. 2149066c.108.1.11: Homoserine kinase ThrH [102304] (1 protein)
    the insertion subdomain is a rudiment 4-helical bundle
    automatically mapped to Pfam PF12710
  12. 2149073c.108.1.12: Class B acid phosphatase, AphA [102307] (1 protein)
    the insertion subdomain is a helical hairpin
    automatically mapped to Pfam PF03767
  13. 2149119c.108.1.13: Hypothetical protein MW1667 (SA1546) [102310] (1 protein)
    the insertion subdomain is multi-helical
  14. 2149123c.108.1.14: NagD-like [102317] (7 protein domains)
    duplication: consists of two segment-swapped domains of this fold; this results in the insertion of a circularly permuted domain after strand 3, analogously to the Cof family
  15. 2149151c.108.1.15: Trehalose-phosphatase [110506] (1 protein)
    Pfam PF02358; contains an insert alpha+beta subdomain; similar overall fold to the Cof family
  16. 2149155c.108.1.16: NLI interacting factor-like phosphatase [110509] (2 protein domains)
    Pfam PF03031; NIF; the insertion subdomain is a 3-stranded beta-sheet;
  17. 2149186c.108.1.17: Magnesium-dependent phosphatase-1, Mdp1 [117509] (2 protein domains)
    the insertion subdomain is a 3-stranded beta-sheet different from the NIF family
    automatically mapped to Pfam PF03031
    automatically mapped to Pfam PF12689
  18. 2149197c.108.1.18: Hypothetical protein VC0232 [117512] (1 protein)
    contains a deletion in the common fold; segment-swapped tetramer
  19. 2149204c.108.1.19: Histidinol phosphatase-like [142177] (3 protein domains)
    no insertion subdomains
  20. 2149234c.108.1.20: MtnX-like [142180] (1 protein)
    Pfam PF06888; the insertion subdomain is a rudiment 4-helical bundle
  21. 2149239c.108.1.21: Pyrimidine 5'-nucleotidase (UMPH-1) [142183] (2 protein domains)
    Pfam PF05822; the insertion subdomain is a rudiment 4-helical bundle
  22. 2149266c.108.1.22: Enolase-phosphatase E1 [142186] (3 protein domains)
    the insertion subdomain is a 4-helical bundle
  23. 2149279c.108.1.23: 5' nucleotidase-like [142191] (1 protein)
    Pfam PF05761; the insertion domain cosists of 3-helical bundle and a pseudo beta-barrel; contains extra C-terminal long alpha hairpin subdomain (46556)
  24. 2149289c.108.1.24: AF1437-like [159537] (1 protein)
    the insertion subdomain is a rudiment 4-helical bundle; extra alpha-hairpin insertion after strand 3
  25. 2149293c.108.1.25: BT0820-like [159540] (1 protein)
    PfamB PB073209; deletion in the common fold; segment-swapped dimer
  26. 2149297c.108.1.0: automated matches [191369] (1 protein)
    not a true family

More info for Superfamily c.108.1: HAD-like

Timeline for Superfamily c.108.1: HAD-like: