Class e: Multi-domain proteins (alpha and beta) [56572] (38 folds) |
Fold e.10: Prokaryotic type I DNA topoisomerase [56711] (1 superfamily) 4 domains: (1) Toprim alpha/beta; (2&4) "winged helix"-like; (3) barrel: n=6, S=8 |
Superfamily e.10.1: Prokaryotic type I DNA topoisomerase [56712] (1 family) duplication: the protein chain passing through the domains 2-4 makes two structural repeats The active site is formed by the toprim and "winged helix" domains (domains 1 and 4); these two domains are also found in the type II topoisomerase (DNA gyrase A) and in the alpha subunit of topoisomerase IV |
Family e.10.1.1: Prokaryotic type I DNA topoisomerase [56713] (3 proteins) domain 4 contains the catalytic tyrosine residue |
Protein DNA topoisomerase I, 67K N-terminal domain [56714] (1 species) |
Species Escherichia coli [TaxId:562] [56715] (10 PDB entries) |
Domain d1cy0a_: 1cy0 A: [43245] complexed with a3p |
Domain d1cy1a_: 1cy1 A: [43242] complexed with po4, thp, tmp |
Domain d1cy2a_: 1cy2 A: [43241] complexed with po4, tmp |
Domain d1cy4a_: 1cy4 A: [43246] complexed with po4, tmp |
Domain d1cy6a_: 1cy6 A: [43247] complexed with po4, t3p |
Domain d1cy7a_: 1cy7 A: [43244] complexed with po4, tmp; mutant |
Domain d1cy8a_: 1cy8 A: [43243] complexed with po4, t3p, tmp |
Domain d1cy9a_: 1cy9 A: [43236] |
Domain d1cy9b_: 1cy9 B: [43237] 2nd and 3rd domains |
Domain d1cyya_: 1cyy A: [43239] |
Domain d1cyyb_: 1cyy B: [43240] 2nd and 3rd domains complexed with zn |
Domain d1ecl__: 1ecl - [43238] mutant |
Timeline for Species Escherichia coli [TaxId:562] from e.10.1.1 DNA topoisomerase I, 67K N-terminal domain: