Lineage for Protein: DNA topoisomerase I, 67K N-terminal domain

  1. Root: SCOPe 2.08
  2. 3012399Class e: Multi-domain proteins (alpha and beta) [56572] (74 folds)
  3. 3018324Fold e.10: Prokaryotic type I DNA topoisomerase [56711] (1 superfamily)
    4 domains: (1) Toprim alpha/beta; (2&4) "winged helix"-like; (3) barrel: n=6, S=8
  4. 3018325Superfamily e.10.1: Prokaryotic type I DNA topoisomerase [56712] (2 families) (S)
    duplication: the protein chain passing through the domains 2-4 makes two structural repeats
    The active site is formed by the toprim and "winged helix" domains (domains 1 and 4); these two domains are also found in the type II topoisomerase (DNA gyrase A) and in the alpha subunit of topoisomerase IV
  5. 3018326Family e.10.1.1: Prokaryotic type I DNA topoisomerase [56713] (4 proteins)
    domain 4 contains the catalytic tyrosine residue
  6. 3018327Protein DNA topoisomerase I, 67K N-terminal domain [56714] (1 species)

Species:

  • 3018328Escherichia coli [TaxId:562] [56715] (12 PDB entries)
    1. Domain for 1cy0:
    2. Domain for 1cy1:
      • 3018341Domain d1cy1a_: 1cy1 A: [43242]
        protein/DNA complex; complexed with po4, thp, tmp
    3. Domain for 1cy2:
    4. Domain for 1cy4:
    5. Domain for 1cy6:
    6. Domain for 1cy7:
    7. Domain for 1cy8:
      • 3018335Domain d1cy8a_: 1cy8 A: [43243]
        protein/DNA complex; complexed with po4, t3p, tmp
    8. Domains for 1cy9:
      1. 3018330Domain d1cy9a_: 1cy9 A: [43236]
        2nd and 3rd domains
        fragment; missing more than one-third of the common structure and/or sequence
      2. 3018331Domain d1cy9b_: 1cy9 B: [43237]
        2nd and 3rd domains
        fragment; missing more than one-third of the common structure and/or sequence
    9. Domains for 1cyy:
      1. 3018338Domain d1cyya_: 1cyy A: [43239]
        2nd and 3rd domains
        complexed with zn

        fragment; missing more than one-third of the common structure and/or sequence
      2. 3018339Domain d1cyyb_: 1cyy B: [43240]
        2nd and 3rd domains
        complexed with zn

        fragment; missing more than one-third of the common structure and/or sequence
    10. Domain for 1ecl:
    11. Domain for 1mw8:
      • 3018332Domain d1mw8x_: 1mw8 X: [91479]
        protein/DNA complex; complexed with so4, tmp; mutant
    12. Domain for 1mw9:

More info for Protein DNA topoisomerase I, 67K N-terminal domain from e.10.1.1: Prokaryotic type I DNA topoisomerase

Timeline for Protein DNA topoisomerase I, 67K N-terminal domain from e.10.1.1: Prokaryotic type I DNA topoisomerase: