Lineage for Family e.10.1.1: Prokaryotic type I DNA topoisomerase

  1. Root: SCOPe 2.07
  2. 2618030Class e: Multi-domain proteins (alpha and beta) [56572] (71 folds)
  3. 2623922Fold e.10: Prokaryotic type I DNA topoisomerase [56711] (1 superfamily)
    4 domains: (1) Toprim alpha/beta; (2&4) "winged helix"-like; (3) barrel: n=6, S=8
  4. 2623923Superfamily e.10.1: Prokaryotic type I DNA topoisomerase [56712] (2 families) (S)
    duplication: the protein chain passing through the domains 2-4 makes two structural repeats
    The active site is formed by the toprim and "winged helix" domains (domains 1 and 4); these two domains are also found in the type II topoisomerase (DNA gyrase A) and in the alpha subunit of topoisomerase IV
  5. 2623924Family e.10.1.1: Prokaryotic type I DNA topoisomerase [56713] (4 proteins)
    domain 4 contains the catalytic tyrosine residue

Proteins:

  1. 2623925DNA topoisomerase I, 67K N-terminal domain [56714] (1 species)
  2. 2623941DNA topoisomerase III [56716] (1 species)
  3. 2623945Topoisomerase "domain" of reverse gyrase [69890] (1 species)
  4. 2623950automated matches [191216] (2 species)
    not a true protein
    1. 2623951Species Escherichia coli K-12 [TaxId:83333] [189588] (1 PDB entry)
    2. 2623953Species Escherichia coli [TaxId:536056] [189925] (1 PDB entry)

More info for Family e.10.1.1: Prokaryotic type I DNA topoisomerase

Timeline for Family e.10.1.1: Prokaryotic type I DNA topoisomerase: