SCOP 1.63: Family e.10.1.1: Prokaryotic type I DNA topoisomerase

Lineage for Family e.10.1.1: Prokaryotic type I DNA topoisomerase

1. Root: SCOP 1.63

2. Class e: Multi-domain proteins (alpha and beta) [56572] (39 folds)

3. Fold e.10: Prokaryotic type I DNA topoisomerase [56711] (1 superfamily)
   4 domains: (1) Toprim alpha/beta; (2&4) "winged helix"-like; (3) barrel: n=6, S=8

4. Superfamily e.10.1: Prokaryotic type I DNA topoisomerase [56712] (1 family)
   duplication: the protein chain passing through the domains 2-4 makes two structural repeats
   The active site is formed by the toprim and "winged helix" domains (domains 1 and 4); these two domains are also found in the type II topoisomerase (DNA gyrase A) and in the alpha subunit of topoisomerase IV

5. Family e.10.1.1: Prokaryotic type I DNA topoisomerase [56713] (3 proteins)
   domain 4 contains the catalytic tyrosine residue

Proteins:

1. DNA topoisomerase I, 67K N-terminal domain [56714] (1 species)

   • Species Escherichia coli [TaxId:562] [56715] (10 PDB entries)

2. DNA topoisomerase III [56716] (1 species)

   • Species Escherichia coli [TaxId:562] [56717] (2 PDB entries)

3. Topoisomerase "domain" of reverse gyrase [69890] (1 species)

   • Species Archaeon Archaeoglobus fulgidus [TaxId:2234] [69891] (2 PDB entries)

More info for Family e.10.1.1: Prokaryotic type I DNA topoisomerase

Timeline for Family e.10.1.1: Prokaryotic type I DNA topoisomerase:

• Family e.10.1.1: Prokaryotic type I DNA topoisomerase first appeared (with stable ids) in SCOP 1.55
  
• Family e.10.1.1: Prokaryotic type I DNA topoisomerase appears in SCOP 1.61
  
• Family e.10.1.1: Prokaryotic type I DNA topoisomerase appears in SCOP 1.65
  
• Family e.10.1.1: Prokaryotic type I DNA topoisomerase appears in the current release, SCOPe 2.08