SCOPe 2.07: Superfamily e.10.1: Prokaryotic type I DNA topoisomerase

Lineage for Superfamily e.10.1: Prokaryotic type I DNA topoisomerase

1. Root: SCOPe 2.07

2. Class e: Multi-domain proteins (alpha and beta) [56572] (71 folds)

3. Fold e.10: Prokaryotic type I DNA topoisomerase [56711] (1 superfamily)
   4 domains: (1) Toprim alpha/beta; (2&4) "winged helix"-like; (3) barrel: n=6, S=8

4. Superfamily e.10.1: Prokaryotic type I DNA topoisomerase [56712] (2 families)
   duplication: the protein chain passing through the domains 2-4 makes two structural repeats
   The active site is formed by the toprim and "winged helix" domains (domains 1 and 4); these two domains are also found in the type II topoisomerase (DNA gyrase A) and in the alpha subunit of topoisomerase IV

Families:

1. e.10.1.1: Prokaryotic type I DNA topoisomerase [56713] (4 proteins)
   domain 4 contains the catalytic tyrosine residue

2. e.10.1.0: automated matches [371215] (1 protein)
   not a true family

More info for Superfamily e.10.1: Prokaryotic type I DNA topoisomerase

Timeline for Superfamily e.10.1: Prokaryotic type I DNA topoisomerase:

• Superfamily e.10.1: Prokaryotic type I DNA topoisomerase first appeared (with stable ids) in SCOP 1.55
  
• Superfamily e.10.1: Prokaryotic type I DNA topoisomerase appears in SCOPe 2.06
  
• Superfamily e.10.1: Prokaryotic type I DNA topoisomerase appears in the current release, SCOPe 2.08