Lineage for Superfamily e.10.1: Prokaryotic type I DNA topoisomerase

1. Root: SCOPe 2.04

2. Class e: Multi-domain proteins (alpha and beta) [56572] (68 folds)

3. Fold e.10: Prokaryotic type I DNA topoisomerase [56711] (1 superfamily) 4 domains: (1) Toprim alpha/beta; (2&4) "winged helix"-like; (3) barrel: n=6, S=8

4. Superfamily e.10.1: Prokaryotic type I DNA topoisomerase [56712] (1 family) duplication: the protein chain passing through the domains 2-4 makes two structural repeats The active site is formed by the toprim and "winged helix" domains (domains 1 and 4); these two domains are also found in the type II topoisomerase (DNA gyrase A) and in the alpha subunit of topoisomerase IV