Lineage for Fold e.10: Prokaryotic type I DNA topoisomerase

  1. Root: SCOP 1.65
  2. 338536Class e: Multi-domain proteins (alpha and beta) [56572] (38 folds)
  3. 339551Fold e.10: Prokaryotic type I DNA topoisomerase [56711] (1 superfamily)
    4 domains: (1) Toprim alpha/beta; (2&4) "winged helix"-like; (3) barrel: n=6, S=8

Superfamily:

  • 339552e.10.1: Prokaryotic type I DNA topoisomerase [56712] (1 family) (S)
    duplication: the protein chain passing through the domains 2-4 makes two structural repeats
    The active site is formed by the toprim and "winged helix" domains (domains 1 and 4); these two domains are also found in the type II topoisomerase (DNA gyrase A) and in the alpha subunit of topoisomerase IV

More info for Fold e.10: Prokaryotic type I DNA topoisomerase

Timeline for Fold e.10: Prokaryotic type I DNA topoisomerase: