SCOP 1.75: Family e.8.1.2: Reverse transcriptase

Lineage for Family e.8.1.2: Reverse transcriptase

1. Root: SCOP 1.75

2. Class e: Multi-domain proteins (alpha and beta) [56572] (66 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (6 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.2: Reverse transcriptase [56686] (2 proteins)

Proteins:

1. HIV-1 reverse transcriptase [56689] (2 species)

   1. Species Human immunodeficiency virus type 1 [TaxId:11676] [56690] (111 PDB entries)
      Uniprot P04585 159-692 # chain A coverage; chain B is shorter: 162-582
      Uniprot P03366 186-725 # chain A coverage; chain B coverage: 156-584
      Uniprot P04585 158-698 # chain A coverage; chain B is shorter: 159-595
      Uniprot P04585 159-692 # chain A coverage; chain B is shorter: 162-582 ! Uniprot P03366 186-725 # chain A coverage; chain B coverage: 156-584 ! Uniprot P04585 158-698 # chain A coverage; chain B is shorter: 159-595

   2. Species Human immunodeficiency virus type 2 [TaxId:11709] [82840] (1 PDB entry)

2. MMLV reverse transcriptase [56687] (1 species)

   • Species Moloney murine leukemia virus, MoMLV [TaxId:11801] [56688] (22 PDB entries)
     Uniprot P03355 RE 144-594

More info for Family e.8.1.2: Reverse transcriptase

Timeline for Family e.8.1.2: Reverse transcriptase:

• Family e.8.1.2: Reverse transcriptase first appeared (with stable ids) in SCOP 1.55
  
• Family e.8.1.2: Reverse transcriptase appears in SCOP 1.73
  
• Family e.8.1.2: Reverse transcriptase appears in SCOPe 2.01
  
• Family e.8.1.2: Reverse transcriptase appears in the current release, SCOPe 2.08