SCOPe 2.06: Family e.8.1.1: DNA polymerase I

Lineage for Family e.8.1.1: DNA polymerase I

1. Root: SCOPe 2.06

2. Class e: Multi-domain proteins (alpha and beta) [56572] (69 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (7 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.1: DNA polymerase I [56673] (5 proteins)

Proteins:

1. DNA polymerase I (Klenow fragment) [56674] (3 species)

   1. Species Bacillus stearothermophilus, newly identified strain as yet unnamed [TaxId:1422] [56677] (44 PDB entries)
      Uniprot Q5KWC1 299-878 # 99% sequence identity; Geobacillus kaustophilus TaxID:1462
      Uniprot Q45458 298-876 # 88% sequence identity

   2. Species Escherichia coli [TaxId:562] [56675] (14 PDB entries)

   3. Species Thermus aquaticus [TaxId:271] [56676] (29 PDB entries)

2. Family B DNA polymerase [56680] (7 species)

   1. Species Bacteriophage RB69 [TaxId:12353] [56681] (92 PDB entries)

   2. Species Desulfurococcus tok [TaxId:108142] [56684] (2 PDB entries)

   3. Species Escherichia coli [TaxId:562] [103399] (1 PDB entry)

   4. Species Pyrococcus kodakaraensis [TaxId:311400] [56685] (2 PDB entries)
      Uniprot P56689 1-758 # 93% sequence identity; Thermococcus kodakarensis KOD1 TaxID: 69014

   5. Species Sulfolobus solfataricus [TaxId:2287] [118192] (1 PDB entry)
      Uniprot P26811 40-864

   6. Species Thermococcus gorgonarius [TaxId:71997] [56682] (1 PDB entry)

   7. Species Thermococcus sp., 9on-7 [TaxId:35749] [56683] (1 PDB entry)

3. phi29 DNA polymerase [118193] (1 species)

   • Species Bacteriophage phi-29 [TaxId:10756] [118194] (8 PDB entries)
     Uniprot P03680

4. T7 phage DNA polymerase [56678] (1 species)

   • Species Bacteriophage T7 [TaxId:10760] [56679] (17 PDB entries)
     Uniprot P00581

5. automated matches [226972] (9 species)
   not a true protein

   1. Species Escherichia coli K-12 [TaxId:83333] [225830] (1 PDB entry)

   2. Species Escherichia coli [TaxId:562] [225831] (3 PDB entries)

   3. Species Geobacillus kaustophilus [TaxId:1462] [233275] (8 PDB entries)

   4. Species Geobacillus kaustophilus [TaxId:235909] [226400] (6 PDB entries)

   5. Species Geobacillus sp. [TaxId:129337] [233671] (4 PDB entries)

   6. Species Geobacillus stearothermophilus [TaxId:1422] [261825] (1 PDB entry)

   7. Species Thermococcus gorgonarius [TaxId:71997] [225934] (3 PDB entries)

   8. Species Thermococcus kodakarensis [TaxId:69014] [226699] (1 PDB entry)

   9. Species Thermus aquaticus [TaxId:271] [267868] (4 PDB entries)

More info for Family e.8.1.1: DNA polymerase I

Timeline for Family e.8.1.1: DNA polymerase I:

• Family e.8.1.1: DNA polymerase I first appeared (with stable ids) in SCOP 1.55
  
• Family e.8.1.1: DNA polymerase I appears in SCOPe 2.05
  
• Family e.8.1.1: DNA polymerase I appears in SCOPe 2.07
  
• Family e.8.1.1: DNA polymerase I appears in the current release, SCOPe 2.08