SCOPe 2.05: Family e.6.1.1: Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains

Lineage for Family e.6.1.1: Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains

1. Root: SCOPe 2.05

2. Class e: Multi-domain proteins (alpha and beta) [56572] (68 folds)

3. Fold e.6: Acyl-CoA dehydrogenase NM domain-like [56644] (1 superfamily)
   2 domains: (1) all-alpha: 5 helices; (2) contains an open beta-sheet barrel: n*=5, S*=8; complex topology

4. Superfamily e.6.1: Acyl-CoA dehydrogenase NM domain-like [56645] (3 families)
   flavoprotein: binds FAD; constituent families differ in the numbers of C-terminal domains (four-helical bundles)

5. Family e.6.1.1: Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains [56646] (10 proteins)

Proteins:

1. 4-hydroxybutyryl-CoA dehydratase AbfD, NM domains [118187] (1 species)

   • Species Clostridium aminobutyricum [TaxId:33953] [118188] (1 PDB entry)
     Uniprot P55792

2. Acyl-CoA dehydrogenase [144024] (1 species)

   • Species Thermus thermophilus [TaxId:274] [144025] (3 PDB entries)
     Uniprot Q5SGZ2 2-234

3. Butyryl-CoA dehydrogenase, NM domains [56647] (2 species)

   1. Species Megasphaera elsdenii [TaxId:907] [56648] (1 PDB entry)

   2. Species Norway rat (Rattus norvegicus) [TaxId:10116] [69877] (1 PDB entry)

4. Glutaryl-CoA dehydrogenase GCDH [111293] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [111294] (3 PDB entries)
     Uniprot Q92947

5. Isobutyryl-CoA dehydrogenase [103394] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [103395] (1 PDB entry)

6. Isovaleryl-coa dehydrogenase, NM domains [56652] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [56653] (1 PDB entry)

7. Medium chain acyl-CoA dehydrogenase, NM domains [56649] (3 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [56651] (5 PDB entries)
      Uniprot P11310 34-421

   2. Species Pig (Sus scrofa) [TaxId:9823] [56650] (3 PDB entries)

   3. Species Thermus thermophilus [TaxId:274] [118186] (1 PDB entry)
      Uniprot Q5SJ70 32-409

8. Nitroalkane oxidase [144026] (1 species)

   • Species Fungus (Fusarium oxysporum) [TaxId:5507] [144027] (2 PDB entries)
     Uniprot Q8X1D8 2-260

9. Protein FkbI [103396] (1 species)
   involved in biosynthesis of methoxymalonyl extender unit of fk520 polyketide immunosuppressant

   • Species Streptomyces hygroscopicus [TaxId:1912] [103397] (1 PDB entry)

10. automated matches [226961] (2 species)
    not a true protein

    1. Species Fungus (Fusarium oxysporum) [TaxId:5507] [231929] (7 PDB entries)

    2. Species Human (Homo sapiens) [TaxId:9606] [225392] (3 PDB entries)

More info for Family e.6.1.1: Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains

Timeline for Family e.6.1.1: Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains:

• Family e.6.1.1: Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains first appeared (with stable ids) in SCOP 1.55, called Family e.6.1.1: Acyl-CoA dehydrogenase (flavoprotein), N-terminal and middle domains
  
• Family e.6.1.1: Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains appears in SCOPe 2.04
  
• Family e.6.1.1: Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains appears in SCOPe 2.06
  
• Family e.6.1.1: Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains appears in the current release, SCOPe 2.08