SCOP 1.69: Family e.6.1.1: Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains

Lineage for Family e.6.1.1: Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains

1. Root: SCOP 1.69

2. Class e: Multi-domain proteins (alpha and beta) [56572] (46 folds)

3. Fold e.6: Acyl-CoA dehydrogenase NM domain-like [56644] (1 superfamily)
   2 domains: (1) all-alpha: 5 helices; (2) contains an open beta-sheet barrel: n*=5, S*=8; complex topology

4. Superfamily e.6.1: Acyl-CoA dehydrogenase NM domain-like [56645] (2 families)
   flavoprotein: binds FAD; constituent families differ in the numbers of C-terminal domains (four-helical bundles)

5. Family e.6.1.1: Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains [56646] (6 proteins)

Proteins:

1. Butyryl-CoA dehydrogenase, NM domains [56647] (2 species)

   1. Species Megasphaera elsdenii [TaxId:907] [56648] (1 PDB entry)

   2. Species Rat (Rattus norvegicus) [TaxId:10116] [69877] (1 PDB entry)

2. Glutaryl-CoA dehydrogenase GCDH [111293] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [111294] (2 PDB entries)

3. Isobutyryl-CoA dehydrogenase [103394] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [103395] (1 PDB entry)

4. Isovaleryl-coa dehydrogenase, NM domains [56652] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [56653] (1 PDB entry)

5. Medium chain acyl-CoA dehydrogenase, NM domains [56649] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [56651] (4 PDB entries)

   2. Species Pig (Sus scrofa) [TaxId:9823] [56650] (3 PDB entries)

6. Protein FkbI [103396] (1 species)
   involved in biosynthesis of methoxymalonyl extender unit of fk520 polyketide immunosuppressant

   • Species Streptomyces hygroscopicus [TaxId:1912] [103397] (1 PDB entry)

More info for Family e.6.1.1: Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains

Timeline for Family e.6.1.1: Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains:

• Family e.6.1.1: Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains first appeared (with stable ids) in SCOP 1.55, called Family e.6.1.1: Acyl-CoA dehydrogenase (flavoprotein), N-terminal and middle domains
  
• Family e.6.1.1: Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains appears in SCOP 1.67
  
• Family e.6.1.1: Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains appears in SCOP 1.71
  
• Family e.6.1.1: Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains appears in the current release, SCOPe 2.08