Lineage for Protein: beta-Lactamase, class A

  1. Root: SCOP 1.75
  2. 883176Class e: Multi-domain proteins (alpha and beta) [56572] (66 folds)
  3. 883341Fold e.3: beta-lactamase/transpeptidase-like [56600] (1 superfamily)
    contains a cluster of helices and an alpha+beta sandwich
  4. 883342Superfamily e.3.1: beta-lactamase/transpeptidase-like [56601] (3 families) (S)
  5. 883343Family e.3.1.1: beta-Lactamase/D-ala carboxypeptidase [56602] (18 proteins)
  6. 883462Protein beta-Lactamase, class A [56606] (15 species)

Species:

  1. 883463Bacillus licheniformis [TaxId:1402] [56612] (5 PDB entries)
    1. Domains for 1i2s:
      1. 883464Domain d1i2sa_: 1i2s A: [71104]
      2. 883465Domain d1i2sb_: 1i2s B: [71105]
        complexed with cit, na
    2. Domains for 1i2w:
      1. 883466Domain d1i2wa_: 1i2w A: [71106]
      2. 883467Domain d1i2wb_: 1i2w B: [71107]
        complexed with cfx, out
    3. Domains for 1mbl:
      1. 883470Domain d1mbla_: 1mbl A: [42723]
      2. 883471Domain d1mblb_: 1mbl B: [42724]
        complexed with so4; mutant
    4. Domains for 2blm:
      1. 883472Domain d2blma_: 2blm A: [42725]
        CA-atoms only
      2. 883473Domain d2blmb_: 2blm B: [42726]
        CA-atoms only
    5. Domains for 4blm:
      1. 883468Domain d4blma_: 4blm A: [42721]
      2. 883469Domain d4blmb_: 4blm B: [42722]
  2. 883474Enterobacter cloacae, NMC-A carbapenemase [TaxId:550] [56613] (2 PDB entries)
    1. Domain for 1bue:
    2. Domain for 1bul:
  3. 883477Escherichia coli, TEM-1 [TaxId:562] [56607] (32 PDB entries)
    1. Domain for 1axb:
    2. Domain for 1bt5:
    3. Domain for 1btl:
    4. Domain for 1ck3:
    5. Domain for 1erm:
    6. Domain for 1ero:
    7. Domain for 1erq:
    8. Domain for 1esu:
    9. Domain for 1fqg:
      • 883498Domain d1fqga_: 1fqg A: [42699]
        acyl-enzyme intermediate
        complexed with pnm; mutant
    10. Domain for 1jtd:
    11. Domains for 1jtg:
      1. 883490Domain d1jtga_: 1jtg A: [67266]
        Other proteins in same PDB: d1jtgb_, d1jtgd_
      2. 883491Domain d1jtgc_: 1jtg C: [67268]
        Other proteins in same PDB: d1jtgb_, d1jtgd_
        complexed with ca; mutant
    12. Domain for 1jvj:
    13. Domain for 1jwp:
    14. Domain for 1jwv:
    15. Domain for 1jwz:
    16. Domain for 1lhy:
    17. Domain for 1li0:
    18. Domain for 1li9:
    19. Domain for 1m40:
      • 883478Domain d1m40a_: 1m40 A: [74437]
        ultra high resolution structure
        complexed with cb4, k, po4; mutant
    20. Domain for 1nxy:
    21. Domain for 1ny0:
    22. Domain for 1nym:
    23. Domain for 1nyy:
    24. Domain for 1pzo:
    25. Domain for 1pzp:
    26. Domains for 1s0w:
      1. 883513Domain d1s0wa_: 1s0w A: [98309]
        Other proteins in same PDB: d1s0wc_, d1s0wd_
      2. 883514Domain d1s0wb_: 1s0w B: [98310]
        Other proteins in same PDB: d1s0wc_, d1s0wd_
        complexed with ca; mutant
    27. Domain for 1tem:
    28. Domain for 1xpb:
    29. Domain for 1zg4:
    30. Domains for 2b5r:
      1. 883488Domain d2b5ra1: 2b5r A:26-288 [144952]
        Other proteins in same PDB: d2b5rc1, d2b5rd1
        mutant
      2. 883489Domain d2b5rb1: 2b5r B:26-288 [144953]
        Other proteins in same PDB: d2b5rc1, d2b5rd1
        automatically matched to 2B5R A:26-288
        mutant
    31. Domains for 3c7u:
      1. 883510Domain d3c7ua1: 3c7u A:26-288 [156017]
        automatically matched to d1axba_
        mutant
      2. 883511Domain d3c7uc1: 3c7u C:26-288 [156018]
        automatically matched to d1axba_
        mutant
    32. Domains for 3c7v:
      1. 883508Domain d3c7va1: 3c7v A:26-288 [156019]
        automatically matched to d1axba_
        mutant
      2. 883509Domain d3c7vc1: 3c7v C:26-288 [156020]
        automatically matched to d1axba_
        mutant
  4. 883515Escherichia coli, TOHO-1 [TaxId:562] [56608] (5 PDB entries)
    1. Domain for 1bza:
    2. Domain for 1iyo:
    3. Domain for 1iyp:
    4. Domain for 1iyq:
    5. Domain for 1iys:
  5. 883521Klebsiella pneumoniae, SHV-1 [TaxId:573] [56609] (15 PDB entries)
    Uniprot Q5PSW7
    Uniprot P14557 22-286
    inhibited by tazobactam
    Uniprot Q5PSW7 ! Uniprot P14557 22-286
    1. Domain for 1ong:
    2. Domain for 1q2p:
    3. Domain for 1rcj:
    4. Domain for 1shv:
    5. Domain for 1tdg:
    6. Domain for 1tdl:
    7. Domain for 1vm1:
    8. Domain for 2a3u:
    9. Domain for 2a49:
    10. Domain for 2g2u:
    11. Domain for 2g2w:
    12. Domain for 2h5s:
    13. Domain for 2zd8:
    14. Domain for 3c4o:
    15. Domain for 3c4p:
  6. 883537Klebsiella pneumoniae, SHV-2 [TaxId:573] [90082] (1 PDB entry)
    almost identical sequence to SHV-1
  7. 883539Klebsiella pneumoniae, TEM52 [TaxId:573] [64473] (1 PDB entry)
  8. 883546Mycobacterium fortuitum [TaxId:1766] [56615] (1 PDB entry)
  9. 883548Proteus vulgaris [TaxId:585] [75596] (1 PDB entry)
  10. 883551Pseudomonas aeruginosa, PER-1 [TaxId:287] [56616] (1 PDB entry)
  11. 883553Pseudomonas aeruginosa, PSE-4 carbenicillinase [TaxId:287] [56610] (2 PDB entries)
    1. Domain for 1g68:
    2. Domain for 1g6a:
  12. 883556Serratia marcescens, Sme-1 [TaxId:615] [56617] (1 PDB entry)
    imipenem-hydrolyzing
  13. 883559Staphylococcus aureus [TaxId:1280] [56611] (16 PDB entries)
    1. Domain for 1alq:
      • 883575Domain d1alqa_: 1alq A: [42707]
        circularly permuted
        complexed with co3, so4; mutant
    2. Domain for 1blc:
    3. Domain for 1blh:
    4. Domain for 1blp:
    5. Domain for 1dja:
    6. Domain for 1djb:
    7. Domain for 1djc:
    8. Domain for 1ghi:
    9. Domain for 1ghm:
    10. Domain for 1ghp:
    11. Domain for 1kge:
    12. Domain for 1kgf:
    13. Domain for 1kgg:
    14. Domains for 1ome:
      1. 883576Domain d1omea_: 1ome A: [42717]
        omega loop deletion mutant (residues 163-178 deleted)
      2. 883577Domain d1omeb_: 1ome B: [42718]
        omega loop deletion mutant (residues 163-178 deleted)
    15. Domains for 1pio:
      1. 883573Domain d1pioa_: 1pio A: [42719]
      2. 883574Domain d1piob_: 1pio B: [42720]
        mutant
    16. Domain for 3blm:
  14. 883578Stenotrophomonas maltophilia, L2 [TaxId:40324] [103374] (2 PDB entries)
    1. Domains for 1n4o:
      1. 883581Domain d1n4oa_: 1n4o A: [91621]
      2. 883582Domain d1n4ob_: 1n4o B: [91622]
        complexed with so4
    2. Domains for 1o7e:
      1. 883579Domain d1o7ea_: 1o7e A: [92622]
      2. 883580Domain d1o7eb_: 1o7e B: [92623]
        complexed with gol, so4
  15. 883583Streptomyces albus G [TaxId:1962] [56614] (1 PDB entry)

More info for Protein beta-Lactamase, class A from e.3.1.1: beta-Lactamase/D-ala carboxypeptidase

Timeline for Protein beta-Lactamase, class A from e.3.1.1: beta-Lactamase/D-ala carboxypeptidase: