Lineage for Protein: beta-Lactamase, class A

  1. Root: SCOP 1.67
  2. 423625Class e: Multi-domain proteins (alpha and beta) [56572] (40 folds)
  3. 423760Fold e.3: beta-lactamase/transpeptidase-like [56600] (1 superfamily)
    contains a cluster of helices and an alpha+beta sandwich
  4. 423761Superfamily e.3.1: beta-lactamase/transpeptidase-like [56601] (2 families) (S)
  5. 423762Family e.3.1.1: beta-Lactamase/D-ala carboxypeptidase [56602] (10 proteins)
  6. 423845Protein beta-Lactamase, class A [56606] (15 species)

Species:

  1. 423846Bacillus licheniformis [TaxId:1402] [56612] (5 PDB entries)
    1. Domains for 1i2s:
      1. 423847Domain d1i2sa_: 1i2s A: [71104]
      2. 423848Domain d1i2sb_: 1i2s B: [71105]
        complexed with cit, na
    2. Domains for 1i2w:
      1. 423849Domain d1i2wa_: 1i2w A: [71106]
      2. 423850Domain d1i2wb_: 1i2w B: [71107]
        complexed with cfx, out
    3. Domains for 1mbl:
      1. 423853Domain d1mbla_: 1mbl A: [42723]
      2. 423854Domain d1mblb_: 1mbl B: [42724]
        complexed with so4; mutant
    4. Domains for 2blm:
      1. 423855Domain d2blma_: 2blm A: [42725]
      2. 423856Domain d2blmb_: 2blm B: [42726]
        CA-atoms only
    5. Domains for 4blm:
      1. 423851Domain d4blma_: 4blm A: [42721]
      2. 423852Domain d4blmb_: 4blm B: [42722]
  2. 423857Enterobacter cloacae, NMC-A carbapenemase [TaxId:550] [56613] (2 PDB entries)
    1. Domain for 1bue:
    2. Domain for 1bul:
  3. 423860Escherichia coli, TEM-1 [TaxId:562] [56607] (28 PDB entries)
    1. Domain for 1axb:
    2. Domain for 1bt5:
    3. Domain for 1btl:
    4. Domain for 1ck3:
    5. Domain for 1erm:
    6. Domain for 1ero:
    7. Domain for 1erq:
    8. Domain for 1esu:
    9. Domain for 1fqg:
      • 423886Domain d1fqga_: 1fqg A: [42699]
        acyl-enzyme intermediate
        complexed with pnm; mutant
    10. Domain for 1jtd:
    11. Domains for 1jtg:
      1. 423868Domain d1jtga_: 1jtg A: [67266]
        Other proteins in same PDB: d1jtgb_, d1jtgd_
      2. 423869Domain d1jtgc_: 1jtg C: [67268]
        Other proteins in same PDB: d1jtgb_, d1jtgd_
        complexed with ca; mutant
    12. Domain for 1jvj:
    13. Domain for 1jwp:
    14. Domain for 1jwv:
    15. Domain for 1jwz:
    16. Domain for 1lhy:
    17. Domain for 1li0:
    18. Domain for 1li9:
    19. Domain for 1m40:
      • 423861Domain d1m40a_: 1m40 A: [74437]
        ultra high resolution structure
        complexed with cb4, k, po4; mutant
    20. Domain for 1nxy:
    21. Domain for 1ny0:
    22. Domain for 1nym:
    23. Domain for 1nyy:
    24. Domain for 1pzo:
    25. Domain for 1pzp:
    26. Domains for 1s0w:
      1. 423888Domain d1s0wa_: 1s0w A: [98309]
        Other proteins in same PDB: d1s0wc_, d1s0wd_
      2. 423889Domain d1s0wb_: 1s0w B: [98310]
        Other proteins in same PDB: d1s0wc_, d1s0wd_
        complexed with ca; mutant
    27. Domain for 1tem:
    28. Domain for 1xpb:
  4. 423891Escherichia coli, TOHO-1 [TaxId:562] [56608] (5 PDB entries)
    1. Domain for 1bza:
    2. Domain for 1iyo:
    3. Domain for 1iyp:
    4. Domain for 1iyq:
    5. Domain for 1iys:
  5. 423897Klebsiella pneumoniae, SHV-1 [TaxId:573] [56609] (4 PDB entries)
    1. Domain for 1g56:
      • 423900Domain d1g56a_: 1g56 A: [42702]
        inhibited by tazobactam
        complexed with akr, ma4, taz
    2. Domain for 1ong:
    3. Domain for 1rcj:
    4. Domain for 1shv:
  6. 423902Klebsiella pneumoniae, SHV-2 [TaxId:573] [90082] (1 PDB entry)
    almost identical sequence to SHV-1
  7. 423904Klebsiella pneumoniae, TEM52 [TaxId:573] [64473] (1 PDB entry)
  8. 423911Mycobacterium fortuitum [TaxId:1766] [56615] (1 PDB entry)
  9. 423913Proteus vulgaris [TaxId:585] [75596] (1 PDB entry)
  10. 423916Pseudomonas aeruginosa, PER-1 [TaxId:287] [56616] (1 PDB entry)
  11. 423918Pseudomonas aeruginosa, PSE-4 carbenicillinase [TaxId:287] [56610] (2 PDB entries)
    1. Domain for 1g68:
    2. Domain for 1g6a:
  12. 423921Serratia marcescens, Sme-1 [TaxId:615] [56617] (1 PDB entry)
    imipenem-hydrolyzing
  13. 423924Staphylococcus aureus [TaxId:1280] [56611] (16 PDB entries)
    1. Domain for 1alq:
      • 423940Domain d1alq__: 1alq - [42707]
        circularly permuted
        complexed with co3, so4; mutant
    2. Domain for 1blc:
    3. Domain for 1blh:
    4. Domain for 1blp:
    5. Domain for 1dja:
    6. Domain for 1djb:
    7. Domain for 1djc:
    8. Domain for 1ghi:
    9. Domain for 1ghm:
    10. Domain for 1ghp:
    11. Domain for 1kge:
    12. Domain for 1kgf:
    13. Domain for 1kgg:
    14. Domains for 1ome:
      1. 423941Domain d1omea_: 1ome A: [42717]
      2. 423942Domain d1omeb_: 1ome B: [42718]
        omega loop deletion mutant (residues 163-178 deleted)
    15. Domains for 1pio:
      1. 423938Domain d1pioa_: 1pio A: [42719]
      2. 423939Domain d1piob_: 1pio B: [42720]
        mutant
    16. Domain for 3blm:
  14. 423943Stenotrophomonas maltophilia, L2 [TaxId:40324] [103374] (2 PDB entries)
    1. Domains for 1n4o:
      1. 423946Domain d1n4oa_: 1n4o A: [91621]
      2. 423947Domain d1n4ob_: 1n4o B: [91622]
        complexed with so4
    2. Domains for 1o7e:
      1. 423944Domain d1o7ea_: 1o7e A: [92622]
      2. 423945Domain d1o7eb_: 1o7e B: [92623]
        complexed with gol, so4
  15. 423948Streptomyces albus G [TaxId:1962] [56614] (1 PDB entry)

More info for Protein beta-Lactamase, class A from e.3.1.1: beta-Lactamase/D-ala carboxypeptidase

Timeline for Protein beta-Lactamase, class A from e.3.1.1: beta-Lactamase/D-ala carboxypeptidase: